Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24650814
TITLE
ADHD symptoms, autistic traits, and substance use and misuse in adult Australian twins.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder frequently co-occur. Several studies show increased risk of substance use disorders in ADHD, yet there is limited information related to how ADHD symptoms, autistic traits, and their combined effects are associated with nicotine, alcohol, and cannabis use and use disorders in the general population.
METHOD NlmCategory: METHODS
Cross-sectional interview and self-report questionnaire data from 3,080 young adult Australian twins (mean age 31.9 years) were used to assess ADHD symptoms, autistic traits, substance use, and substance use disorders. Substance use disorders-based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria-were assessed in the full sample as well as in those who reported substance use. Logistic regression analyses were used for comparing the associations between ADHD symptoms, autistic traits, substance use, and substance misuse after conduct disorder, sex, age, and zygosity were controlled for.
RESULTS NlmCategory: RESULTS
Greater ADHD symptoms and autistic traits scores were associated with elevated levels of regular smoking; cannabis use; and nicotine, alcohol, and cannabis use disorders, even after conduct disorder was adjusted for. In contrast, for alcohol use, those with high autistic traits scores were less likely to report drinking to intoxication. However, upon initiation, and similar to the findings for nicotine and cannabis, they were at elevated risk for developing alcohol dependence.
CONCLUSIONS NlmCategory: CONCLUSIONS
Increased liability to ADHD and elevated autistic traits scores were associated with substance use and misuse, with the exception of alcohol use. Given the social underpinnings of drinking, persons with autistic traits may be less likely to engage in it; however, upon engagement in drinking, their vulnerability to alcohol dependence is elevated.
DATE PUBLISHED
2014 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/03/22 06:00
pubmed 2014/03/22 06:00
medline 2014/12/15 06:00
pmc-release 2015/03/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
De Alwis D De Alwis Duneesha D Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Reiersen AM Reiersen Angela M AM Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Constantino JN Constantino John N JN Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Henders A Henders Anjali A Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Lynskey MT Lynskey Michael T MT Kings College, London, England.
INVESTIGATORS
JOURNAL
VOLUME: 75
ISSUE: 2
TITLE: Journal of studies on alcohol and drugs
ISOABBREVIATION: J Stud Alcohol Drugs
YEAR: 2014
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-4114
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Stud Alcohol Drugs
COUNTRY: United States
ISSNLINKING: 1937-1888
NLMUNIQUEID: 101295847
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
DA18267 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
HD042541 NICHD NIH HHS United States
K02 DA032573 NIDA NIH HHS United States
K08 MH080287 NIMH NIH HHS United States
MH-080287 NIMH NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01 HD042541 NICHD NIH HHS United States
T32 DA007313 NIDA NIH HHS United States
T32DA007313 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Attention Deficit Disorder with Hyperactivity psychology
Australia epidemiology
Autistic Disorder psychology
Cross-Sectional Studies psychology
Diseases in Twins psychology
Female psychology
Humans psychology
Male psychology
Questionnaires psychology
Substance-Related Disorders psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3965675 [Available on 03/01/15] NLM