Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
24588857
TITLE
Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study.
ABSTRACT
Accumulating evidence suggests that the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for cannabis abuse and dependence are best represented by a single underlying factor. However, it remains possible that models with additional factors, or latent class models or hybrid models, may better explain the data. Using structured interviews, 626 adult male and female twins provided complete data on symptoms of cannabis abuse and dependence, plus a craving criterion. We compared latent factor analysis, latent class analysis, and factor mixture modeling using normal theory marginal maximum likelihood for ordinal data. Our aim was to derive a parsimonious, best-fitting cannabis use disorder (CUD) phenotype based on DSM-IV criteria and determine whether DSM-5 craving loads onto a general factor. When compared with latent class and mixture models, factor models provided a better fit to the data. When conditioned on initiation and cannabis use, the association between criteria for abuse, dependence, withdrawal, and craving were best explained by two correlated latent factors for males and females: a general risk factor to CUD and a factor capturing the symptoms of social and occupational impairment as a consequence of frequent use. Secondary analyses revealed a modest increase in the prevalence of DSM-5 CUD compared with DSM-IV cannabis abuse or dependence. It is concluded that, in addition to a general factor with loadings on cannabis use and symptoms of abuse, dependence, withdrawal, and craving, a second clinically relevant factor defined by features of social and occupational impairment was also found for frequent cannabis use.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2014/03/03
entrez 2014/03/05 06:00
pubmed 2014/03/05 06:00
medline 2014/06/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kubarych TS Kubarych Thomas S TS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Kendler KS Kendler Kenneth S KS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Aggen SH Aggen Steven H SH Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Estabrook R Estabrook Ryne R Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Edwards AC Edwards Alexis C AC Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Clark SL Clark Shaunna L SL School of Pharmacy, Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, 1112 East Clay Street, McGuire Hall, Richmond, VA, USA.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, QLD, Australia.
Hickie IB Hickie Ian B IB Brain & Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW, Australia.
Neale MC Neale Michael C MC Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Gillespie NA Gillespie Nathan A NA Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Psychol Med. 2007 Sep;37(9):1345-55 17407621
Cites Addiction. 2007 Jun;102(6):920-30 17523987
Cites Drug Alcohol Depend. 2009 Mar 1;100(3):221-7 19062204
Cites Addiction. 2010 Feb;105(2):240-54 20078482
Cites Addiction. 2010 Mar;105(3):417-30 20402985
Cites J Stud Alcohol Drugs. 2010 May;71(3):418-23 20409436
Cites Int J Methods Psychiatr Res. 2010 Jun;19(2):63-73 20187060
Cites Addiction. 2010 Jul;105(7):1246-53 20491729
Cites J Stud Alcohol Drugs. 2010 Sep;71(5):674-84 20731972
Cites Psychol Med. 2011 Mar;41(3):629-40 20459881
Cites Addiction. 2011 May;106(5):941-50 21205055
Cites Addiction. 2011 Nov;106(11):1935-43 21631621
Cites Drug Alcohol Depend. 2011 Nov 1;118(2-3):166-72 21507586
Cites J Stud Alcohol Drugs. 2012 Mar;73(2):328-36 22333341
Cites Psychol Addict Behav. 2012 Mar;26(1):68-77 22082343
Cites Drug Alcohol Depend. 2012 Apr 1;122(1-2):28-37 21963333
Cites Neuroscience. 2012 Jun 1;211:107-25 21864653
Cites Nat Neurosci. 2012 Nov;15(11):1475-84 23064380
Cites Mol Psychiatry. 2012 Dec;17(12):1306-15 22105626
Cites Addict Behav. 2013 Feb;38(2):1532-40 23148916
Cites Twin Res Hum Genet. 2013 Feb;16(1):21-33 23187020
Cites Alcohol Clin Exp Res. 2013 Mar;37(3):443-51 23347196
Cites J Stud Alcohol Drugs. 2013 Jul;74(4):614-21 23739026
Cites Addiction. 1999 Jun;94(6):843-55 10665074
Cites Biometrics. 1999 Jun;55(2):463-9 11318201
Cites Drug Alcohol Depend. 2001 Nov 1;64(3):347-61 11672949
Cites Drug Alcohol Depend. 2002 Dec 1;68(3):255-62 12393220
Cites Addiction. 2002 Dec;97 Suppl 1:4-15 12460125
Cites J Abnorm Psychol. 2004 Feb;113(1):72-80 14992659
Cites Psychol Methods. 2004 Mar;9(1):3-29 15053717
Cites Bull World Health Organ. 1981;59(2):225-42 6972816
Cites Drug Alcohol Depend. 1995 Aug;39(2):99-109 8529538
Cites Addiction. 1995 Dec;90(12):1661-9 8555957
Cites Trends Neurosci. 1999 Apr;22(4):173-9 10203855
Cites Neurosci Biobehav Rev. 2005 Jan;28(8):785-802 15642621
Cites Drug Alcohol Depend. 2005 Oct 1;80(1):105-16 16157233
Cites Int J Methods Psychiatr Res. 2005;14(2):69-81 16175876
Cites Arch Gen Psychiatry. 2005 Dec;62(12):1352-9 16330723
Cites Psychol Methods. 2006 Mar;11(1):36-53 16594766
Cites Addict Behav. 2006 Jun;31(6):1010-34 16723188
Cites Psychol Med. 2006 Jul;36(7):931-41 16563205
Cites Twin Res Hum Genet. 2006 Jun;9(3):412-23 16790151
Cites Addiction. 2006 Sep;101 Suppl 1:6-16 16930156
Cites Drug Alcohol Depend. 2007 May 11;88(2-3):300-7 17084563
Cites J Am Acad Child Adolesc Psychiatry. 2008 Feb;47(2):165-73 18176333
GRANTS
GRANTID AGENCY COUNTRY
DA-18673 NIDA NIH HHS United States
DA-21169 NIDA NIH HHS United States
K01 AA021266 NIAAA NIH HHS United States
K01 AA021399 NIAAA NIH HHS United States
K99 DA023549 NIDA NIH HHS United States
R00 DA023549 NIDA NIH HHS United States
R00DA023549 NIDA NIH HHS United States
R01 DA018673 NIDA NIH HHS United States
R37 DA018673 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Longitudinal Studies
Male
Marijuana Abuse epidemiology
Models, Theoretical epidemiology
Twins statistics & numerical data
Young Adult statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS573053 NLM
PMC3996924 NLM