Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24588857
TITLE
Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study.
ABSTRACT
Accumulating evidence suggests that the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for cannabis abuse and dependence are best represented by a single underlying factor. However, it remains possible that models with additional factors, or latent class models or hybrid models, may better explain the data. Using structured interviews, 626 adult male and female twins provided complete data on symptoms of cannabis abuse and dependence, plus a craving criterion. We compared latent factor analysis, latent class analysis, and factor mixture modeling using normal theory marginal maximum likelihood for ordinal data. Our aim was to derive a parsimonious, best-fitting cannabis use disorder (CUD) phenotype based on DSM-IV criteria and determine whether DSM-5 craving loads onto a general factor. When compared with latent class and mixture models, factor models provided a better fit to the data. When conditioned on initiation and cannabis use, the association between criteria for abuse, dependence, withdrawal, and craving were best explained by two correlated latent factors for males and females: a general risk factor to CUD and a factor capturing the symptoms of social and occupational impairment as a consequence of frequent use. Secondary analyses revealed a modest increase in the prevalence of DSM-5 CUD compared with DSM-IV cannabis abuse or dependence. It is concluded that, in addition to a general factor with loadings on cannabis use and symptoms of abuse, dependence, withdrawal, and craving, a second clinically relevant factor defined by features of social and occupational impairment was also found for frequent cannabis use.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2014/03/03
entrez 2014/03/05 06:00
pubmed 2014/03/05 06:00
medline 2014/06/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kubarych TS Kubarych Thomas S TS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Kendler KS Kendler Kenneth S KS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Aggen SH Aggen Steven H SH Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Estabrook R Estabrook Ryne R Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Edwards AC Edwards Alexis C AC Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Clark SL Clark Shaunna L SL School of Pharmacy, Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, 1112 East Clay Street, McGuire Hall, Richmond, VA, USA.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, QLD, Australia.
Hickie IB Hickie Ian B IB Brain & Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW, Australia.
Neale MC Neale Michael C MC Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Gillespie NA Gillespie Nathan A NA Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
INVESTIGATORS
JOURNAL
VOLUME: 17
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
DA-18673 NIDA NIH HHS United States
DA-21169 NIDA NIH HHS United States
K01 AA021266 NIAAA NIH HHS United States
K01 AA021399 NIAAA NIH HHS United States
K99 DA023549 NIDA NIH HHS United States
R00 DA023549 NIDA NIH HHS United States
R00DA023549 NIDA NIH HHS United States
R01 DA018673 NIDA NIH HHS United States
R37 DA018673 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Longitudinal Studies
Male
Marijuana Abuse epidemiology
Models, Theoretical epidemiology
Twins statistics & numerical data
Young Adult statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS573053 NLM
PMC3996924 NLM
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Last Modified: Oct 15 2007