|
|
| PMID |
|
|
| TITLE |
|
| Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| To date, no genome-wide association study (GWAS) has considered the combined phenotype of asthma with hay fever. Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma without hay fever. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| We sought to perform a GWAS of asthma with hay fever to identify variants associated with having both diseases. |
| METHODS |
NlmCategory: METHODS |
| We performed a meta-analysis of GWASs comparing persons with both physician-diagnosed asthma and hay fever (n = 6,685) with persons with neither disease (n = 14,091). |
| RESULTS |
NlmCategory: RESULTS |
| At genome-wide significance, we identified 11 independent variants associated with the risk of having asthma with hay fever, including 2 associations reaching this level of significance with allergic disease for the first time: ZBTB10 (rs7009110; odds ratio [OR], 1.14; P = 4 × 10(-9)) and CLEC16A (rs62026376; OR, 1.17; P = 1 × 10(-8)). The rs62026376:C allele associated with increased asthma with hay fever risk has been found to be associated also with decreased expression of the nearby DEXI gene in monocytes. The 11 variants were associated with the risk of asthma and hay fever separately, but the estimated associations with the individual phenotypes were weaker than with the combined asthma with hay fever phenotype. A variant near LRRC32 was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP. Single nucleotide polymorphisms with suggestive evidence for association with asthma with hay fever risk included rs41295115 near IL2RA (OR, 1.28; P = 5 × 10(-7)) and rs76043829 in TNS1 (OR, 1.23; P = 2 × 10(-6)). |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| By focusing on the combined phenotype of asthma with hay fever, variants associated with the risk of allergic disease can be identified with greater efficiency. |
| Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/05/31 |
| revised |
2013/10/03 |
| accepted |
2013/10/09 |
| aheadofprint |
2013/12/31 |
| entrez |
2014/01/07 06:00 |
| pubmed |
2014/01/07 06:00 |
| medline |
2014/07/19 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ferreira MA |
|
Ferreira |
Manuel A R |
MA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. Electronic address: manuel.ferreira@qimrberghofer.edu.au. |
| Matheson MC |
|
Matheson |
Melanie C |
MC |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Tang CS |
|
Tang |
Clara S |
CS |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; Departments of Psychiatry, Surgery, and Medicine, Centre for Genomic Sciences, University of Hong Kong, Hong Kong, China. |
| Granell R |
|
Granell |
Raquel |
R |
|
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
| Ang W |
|
Ang |
Wei |
W |
|
School of Women's and Infant's Health, University of Western Australia, Subiaco, Australia. |
| Hui J |
|
Hui |
Jennie |
J |
|
PathWest Laboratory Medicine of Western Australia, Nedlands, Australia; School of Population Health, University of Western Australia, Nedlands, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia; Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia. |
| Kiefer AK |
|
Kiefer |
Amy K |
AK |
|
23andMe, Mountain View, Calif. |
| Duffy DL |
|
Duffy |
David L |
DL |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Baltic S |
|
Baltic |
Svetlana |
S |
|
Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia. |
| Danoy P |
|
Danoy |
Patrick |
P |
|
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia. |
| Bui M |
|
Bui |
Minh |
M |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Price L |
|
Price |
Loren |
L |
|
Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia. |
| Sly PD |
|
Sly |
Peter D |
PD |
|
Queensland Children's Medical Research Institute, Royal Children's Hospital, Brisbane, Australia. |
| Eriksson N |
|
Eriksson |
Nicholas |
N |
|
23andMe, Mountain View, Calif. |
| Madden PA |
|
Madden |
Pamela A |
PA |
|
Department of Psychiatry, Washington University School, of Medicine, St Louis, Mo. |
| Abramson MJ |
|
Abramson |
Michael J |
MJ |
|
Department of Epidemiology & Preventive Medicine, Monash University, Melbourne, Australia. |
| Holt PG |
|
Holt |
Patrick G |
PG |
|
Telethon Institute of Child Health Research, University of Western Australia, Subiaco, Australia. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, Washington University School, of Medicine, St Louis, Mo. |
| Hunter M |
|
Hunter |
Michael |
M |
|
School of Population Health, University of Western Australia, Nedlands, Australia; Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia. |
| Musk B |
|
Musk |
Bill |
B |
|
School of Population Health, University of Western Australia, Nedlands, Australia; Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Australia. |
| Robertson CF |
|
Robertson |
Colin F |
CF |
|
Respiratory Medicine, Murdoch Children's Research Institute, Melbourne, Australia. |
| Le Souëf P |
|
Le Souëf |
Peter |
P |
|
School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Henderson AJ |
|
Henderson |
A John |
AJ |
|
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
| Tung JY |
|
Tung |
Joyce Y |
JY |
|
23andMe, Mountain View, Calif. |
| Dharmage SC |
|
Dharmage |
Shyamali C |
SC |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Brown MA |
|
Brown |
Matthew A |
MA |
|
University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia. |
| James A |
|
James |
Alan |
A |
|
Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia; Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Nedlands, Australia. |
| Thompson PJ |
|
Thompson |
Philip J |
PJ |
|
Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia. |
| Pennell C |
|
Pennell |
Craig |
C |
|
School of Women's and Infant's Health, University of Western Australia, Subiaco, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Evans DM |
|
Evans |
David M |
DM |
|
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom. |
| Hinds DA |
|
Hinds |
David A |
DA |
|
23andMe, Mountain View, Calif. |
| Hopper JL |
|
Hopper |
John L |
JL |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. Electronic address: j.hopper@unimelb.edu.au. |
|
Australian Asthma Genetics Consortium Collaborators |
|
|
|
|
|
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Nyholta |
Dale R |
DR |
|
| Beilbyb-d |
John |
J |
|
| Cheahe |
Faang |
F |
|
| Mészárosf |
Desiree |
D |
|
| Gordona |
Scott D |
SD |
|
| Southeyg |
Melissa C |
MC |
|
| Wrighta |
Margaret J |
MJ |
|
| Markosh |
James |
J |
|
| Chunge |
Li P |
LP |
|
| Hendersa |
Anjali K |
AK |
|
| Gilesi |
Graham |
G |
|
| Templee |
Suzanna |
S |
|
| Whitfielda |
John |
J |
|
| Sheltone |
Brad |
B |
|
| Mitrpante |
Chalermchai |
C |
|
| Jenkinsj |
Mark |
M |
|
| Waltersf |
Haydn |
H |
|
|
| JOURNAL |
|
| VOLUME: 133 |
| ISSUE: 6 |
| TITLE: The Journal of allergy and clinical immunology |
| ISOABBREVIATION: J. Allergy Clin. Immunol. |
| YEAR: 2014 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1097-6825 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Allergy Clin Immunol |
| COUNTRY: United States |
| ISSNLINKING: 0091-6749 |
| NLMUNIQUEID: 1275002 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
J Immunol. 2000 Jul 1;165(1):286-91 |
10861063 |
|
| Cites |
PLoS One. 2012;7(9):e44008 |
23028483 |
|
| Cites |
Biometrics. 1999 Dec;55(4):997-1004 |
11315092 |
|
| Cites |
J Biol Chem. 2002 Mar 15;277(11):8890-7 |
11751910 |
|
| Cites |
J Allergy Clin Immunol. 2002 Mar;109(3):419-25 |
11897985 |
|
| Cites |
J Allergy Clin Immunol. 2003 Jun;111(6):1171-83; quiz 1184 |
12789212 |
|
| Cites |
Nat Genet. 2004 Apr;36(4):388-93 |
15052270 |
|
| Cites |
Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1351-8 |
2252253 |
|
| Cites |
Lancet. 1993 Oct 9;342(8876):887-91 |
8105165 |
|
| Cites |
Science. 1994 Jul 29;265(5172):682-4 |
8036519 |
|
| Cites |
Early Hum Dev. 1996 Jul 19;45(3):203-14 |
8855394 |
|
| Cites |
BMJ. 1997 Jun 28;314(7098):1864-8 |
9224128 |
|
| Cites |
J Biol Chem. 1998 May 22;273(21):13097-103 |
9582348 |
|
| Cites |
J Biol Chem. 1999 Mar 19;274(12):8123-8 |
10075714 |
|
| Cites |
J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):301-4 |
10452748 |
|
| Cites |
Clin Exp Allergy. 2006 Nov;36(11):1382-90 |
17083348 |
|
| Cites |
Med J Aust. 2006 Nov 20;185(10):565-71 |
17115970 |
|
| Cites |
Nat Genet. 2007 Jul;39(7):857-64 |
17554260 |
|
| Cites |
Nature. 2007 Jul 26;448(7152):470-3 |
17611496 |
|
| Cites |
N Engl J Med. 2007 Aug 30;357(9):851-62 |
17660530 |
|
| Cites |
Nat Genet. 2007 Oct;39(10):1202-7 |
17873877 |
|
| Cites |
J Allergy Clin Immunol. 2007 Oct;120(4):863-9 |
17825896 |
|
| Cites |
Genet Epidemiol. 2008 May;32(4):381-5 |
18348202 |
|
| Cites |
J Biol Chem. 2008 May 30;283(22):15134-41 |
18378679 |
|
| Cites |
PLoS Biol. 2008 May 6;6(5):e107 |
18462017 |
|
| Cites |
Lancet. 2008 Sep 20;372(9643):1049-57 |
18805333 |
|
| Cites |
Am J Hum Genet. 2009 May;84(5):581-93 |
19426955 |
|
| Cites |
Am J Hum Genet. 2009 Nov;85(5):745-9 |
19853236 |
|
| Cites |
Nat Genet. 2010 Jan;42(1):36-44 |
20010834 |
|
| Cites |
Nat Genet. 2010 Dec;42(12):1118-25 |
21102463 |
|
| Cites |
Am J Hum Genet. 2010 Dec 10;87(6):779-89 |
21129726 |
|
| Cites |
PLoS One. 2011;6(5):e19719 |
21625490 |
|
| Cites |
Eur J Hum Genet. 2011 Jul;19(7):807-12 |
21407268 |
|
| Cites |
PLoS Genet. 2011 Jul;7(7):e1002170 |
21814517 |
|
| Cites |
Nat Genet. 2012 Nov;44(11):1222-6 |
23042114 |
|
| Cites |
J Allergy Clin Immunol. 2012 Nov;130(5):1117-1122.e1 |
23021888 |
|
| Cites |
Nature. 2012 Nov 1;491(7422):119-24 |
23128233 |
|
| Cites |
Clin Exp Allergy. 2012 Dec;42(12):1724-33 |
23181788 |
|
| Cites |
Genes Immun. 2013 Jan;14(1):62-6 |
23151489 |
|
| Cites |
N Engl J Med. 2010 Jan 7;362(1):36-44 |
20032318 |
|
| Cites |
Am J Hum Genet. 2010 Jan;86(1):88-92 |
20045101 |
|
| Cites |
N Engl J Med. 2010 May 6;362(18):1686-97 |
20410501 |
|
| Cites |
Nat Genet. 2010 Jun;42(6):508-14 |
20453842 |
|
| Cites |
PLoS One. 2010;5(5):e10693 |
20502693 |
|
| Cites |
Nature. 2010 Jul 1;466(7302):113-7 |
20596022 |
|
| Cites |
Bioinformatics. 2010 Sep 1;26(17):2190-1 |
20616382 |
|
| Cites |
N Engl J Med. 2010 Sep 23;363(13):1211-21 |
20860503 |
|
| Cites |
Nat Genet. 2011 Apr;43(4):329-32 |
21399635 |
|
| Cites |
Int J Epidemiol. 2013 Feb;42(1):111-27 |
22507743 |
|
| Cites |
Nat Genet. 2013 Aug;45(8):907-11 |
23817569 |
|
| Cites |
Nat Genet. 2013 Aug;45(8):902-6 |
23817571 |
|
| Cites |
PLoS Genet. 2011 Aug;7(8):e1002216 |
21829393 |
|
| Cites |
Nature. 2011 Aug 11;476(7359):214-9 |
21833088 |
|
| Cites |
Nat Genet. 2011 Sep;43(9):893-6 |
21804548 |
|
| Cites |
Nat Genet. 2011 Sep;43(9):887-92 |
21804549 |
|
| Cites |
Lancet. 2011 Sep 10;378(9795):1006-14 |
21907864 |
|
| Cites |
J Allergy Clin Immunol. 2011 Nov;128(5):996-1005 |
22036096 |
|
| Cites |
Hum Mol Genet. 2012 Jan 15;21(2):322-33 |
21989056 |
|
| Cites |
Nat Genet. 2012 Feb;44(2):187-92 |
22197932 |
|
| Cites |
Hum Genet. 2012 May;131(5):747-56 |
22143225 |
|
| Cites |
Nat Genet. 2012 May;44(5):502-10 |
22446964 |
|
| Cites |
Clin Exp Allergy. 2012 Jul;42(7):1097-103 |
22702508 |
|
| Cites |
Thorax. 2012 Sep;67(9):762-8 |
22561531 |
|
| Cites |
Genet Epidemiol. 2001 Jan;20(1):4-16 |
11119293 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10248 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| AA17688 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| MC_PC_15018 |
Medical Research Council |
United Kingdom |
| MH66206 |
NIMH NIH HHS |
United States |
| MOP-82893 |
Canadian Institutes of Health Research |
Canada |
| P60 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Rhinitis |
| atopy |
| bivariate |
| genetic correlation |
| selection |
| single nucleotide polymorphism |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Alleles |
|
| Asthma |
genetics |
| Female |
genetics |
| Gene Frequency |
genetics |
| Genetic Variation |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Lectins, C-Type |
genetics |
| Linkage Disequilibrium |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Monosaccharide Transport Proteins |
genetics |
| Odds Ratio |
genetics |
| Phenotype |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Quantitative Trait Loci |
genetics |
| Repressor Proteins |
genetics |
| Rhinitis, Allergic, Seasonal |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
CLEC16A protein, human |
| 0 |
Lectins, C-Type |
| 0 |
Monosaccharide Transport Proteins |
| 0 |
Repressor Proteins |
| 0 |
ZBTB10 protein, human |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS553108 |
NLM |
| PMC4280183 |
NLM |
|
|
