Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24366676
TITLE
Perceived stress has genetic influences distinct from neuroticism and depression.
ABSTRACT
The present study investigated whether the genetic determinants of neuroticism and depressive symptoms differ from those underlying perceived psychological stress. Multivariate structural equation models, which included age and sex as modifiers, were fitted to the total sample of 798 adolescents and young adults (female, n = 459; mean age 15.5 years). The sample included 139 monozygotic and 241 dizygotic twin pairs. Stress was measured using item response theory (IRT) scores, as derived from the Perceived Stress Scale and/or the Daily Life and Stressors Scale. Neuroticism was measured using the Neo-Five Factor Inventory or the Junior Eysenck Personality Questionnaire, depending on the age of the participant. Depressive symptoms were assessed using the IRT-scores of the Somatic and Psychological Health Report. The results suggest that the genetic effects underlying perceived psychological stress are largely shared with those that influence neuroticism and liability to depressive symptoms. However, separate genetic effects for perceived psychological stress that are not shared with neuroticism and depressive symptoms were also identified. The source of the identified trait specific effects requires further investigation.
DATE PUBLISHED
2014 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/11/06
accepted 2013/12/13
aheadofprint 2013/12/24
entrez 2013/12/25 06:00
pubmed 2013/12/25 06:00
medline 2015/07/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Rietschel L Rietschel Liz L Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, Australia, l.rietschel@uke.de.
Zhu G Zhu Gu G
Kirschbaum C Kirschbaum Clemens C
Strohmaier J Strohmaier Jana J
Wüst S Wüst Stefan S
Rietschel M Rietschel Marcella M
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 44
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2014
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Anxiety Disorders genetics
Child genetics
Depressive Disorder genetics
Diseases in Twins genetics
Female genetics
Humans genetics
Male genetics
Multivariate Analysis genetics
Personality Inventory genetics
Stress, Psychological genetics
Surveys and Questionnaires genetics
Young Adult genetics
SUPPLEMENTARY MESH
SUPPLMESHNAME SUPPLMESHTYPE
Neuroticism Disease
GENE SYMBOLS
CHEMICALS
OTHER ID's