Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24252847
TITLE
Modeling of the hemodynamic responses in block design fMRI studies.
ABSTRACT
The hemodynamic response function (HRF) describes the local response of brain vasculature to functional activation. Accurate HRF modeling enables the investigation of cerebral blood flow regulation and improves our ability to interpret fMRI results. Block designs have been used extensively as fMRI paradigms because detection power is maximized; however, block designs are not optimal for HRF parameter estimation. Here we assessed the utility of block design fMRI data for HRF modeling. The trueness (relative deviation), precision (relative uncertainty), and identifiability (goodness-of-fit) of different HRF models were examined and test-retest reproducibility of HRF parameter estimates was assessed using computer simulations and fMRI data from 82 healthy young adult twins acquired on two occasions 3 to 4 months apart. The effects of systematically varying attributes of the block design paradigm were also examined. In our comparison of five HRF models, the model comprising the sum of two gamma functions with six free parameters had greatest parameter accuracy and identifiability. Hemodynamic response function height and time to peak were highly reproducible between studies and width was moderately reproducible but the reproducibility of onset time was low. This study established the feasibility and test-retest reliability of estimating HRF parameters using data from block design fMRI studies.
DATE PUBLISHED
2014 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/07/09
revised 2013/10/17
accepted 2013/10/21
aheadofprint 2013/11/20
entrez 2013/11/21 06:00
pubmed 2013/11/21 06:00
medline 2014/03/26 06:00
pmc-release 2015/02/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Shan ZY Shan Zuyao Y ZY Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Wright MJ Wright Margaret J MJ Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Laboratory of NeuroImaging, Department of Neurology & Psychiatry, UCLA School of Medicine, Los Angeles, California, USA.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Blokland GG Blokland Gabriella G A M GG Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Vinkhuyzen AA Vinkhuyzen Anna A E AA Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Reutens DC Reutens David C DC Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 34
ISSUE: 2
TITLE: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISOABBREVIATION: J. Cereb. Blood Flow Metab.
YEAR: 2014
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1559-7016
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Cereb Blood Flow Metab
COUNTRY: United States
ISSNLINKING: 0271-678X
NLMUNIQUEID: 8112566
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
R01HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Blood Flow Velocity
Cerebrovascular Circulation
Computer Simulation
Female
Humans
Magnetic Resonance Angiography
Male
Models, Cardiovascular
Reproducibility of Results
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3915209 [Available on 02/01/15] NLM