Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24179306
TITLE
Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins.
ABSTRACT
STUDY OBJECTIVES NlmCategory: OBJECTIVE
To examine the role of genetic and environmental factors on sleep behavior in 12-year-old twins matched for family environment.
DESIGN NlmCategory: METHODS
Population-based twin cohort.
SETTING NlmCategory: METHODS
Participants were assessed in their home environment.
PATIENTS OR PARTICIPANTS NlmCategory: METHODS
One hundred thirty-two adolescent twins comprising 25 monozygotic (MZ) and 41 dizygotic (DZ) twin pairs; aged 12.2 ± 0.1 y (mean ± standard deviation).
INTERVENTIONS NlmCategory: METHODS
N/A.
MEASUREMENTS AND RESULTS NlmCategory: RESULTS
For 2 weeks in their home environment, participants wore a wrist activity monitor and completed a daily sleep diary. Sleep diaries included reports of bedtime, wake time, and estimated sleep onset time. Mean timing, duration, and quality of sleep during the 2 weeks were calculated for each individual and compared within twin pairs. MZ twin correlations were higher than the DZ correlations for total sleep time (MZr = 0.64; DZr = 0.38) and sleep onset latency (MZr = 0.83; DZr = 0.53) and significantly higher for wake after sleep onset (MZr = 0.66; DZr = 0.04) and sleep efficiency (MZr = 0.82; DZr = 0.10). Univariate modeling showed additive genetic factors accounted for 65% of the variance in total sleep time, 83% in sleep onset latency, and 52% and 57% of the variance in wake after sleep onset and sleep efficiency, respectively. A predominant influence of shared environment was found on the timing of sleep (67% for sleep start time, 86% for sleep end time).
CONCLUSIONS NlmCategory: CONCLUSIONS
There is a strong genetic influence on the sleep-wake patterns of 12-year-old adolescents. Genes have a greater influence on sleep initiation and sleep maintenance and a smaller role in sleep timing, likely to be influenced by family environment.
DATE PUBLISHED
2013 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/11/02 06:00
pubmed 2013/11/02 06:00
medline 2014/07/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Sletten TL Sletten Tracey L TL School of Psychology and Psychiatry, Monash University, Melbourne, Australia.
Rajaratnam SM Rajaratnam Shantha M W SM
Wright MJ Wright Margaret J MJ
Zhu G Zhu Gu G
Naismith S Naismith Sharon S
Martin NG Martin Nicholas G NG
Hickie I Hickie Ian I
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE: 11
TITLE: Sleep
ISOABBREVIATION: Sleep
YEAR: 2013
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1550-9109
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sleep
COUNTRY: United States
ISSNLINKING: 0161-8105
NLMUNIQUEID: 7809084
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Adolescence
environmental influences
genetics
heritability
sleep
twins
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Actigraphy
Child
Environment
Female
Humans
Male
Sleep physiology
Twins psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
Wakefulness physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3792390 NLM