Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
24144296
TITLE
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
ABSTRACT
Refractive errors are common eye disorders of public health importance worldwide. Ocular axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We conducted a meta-analysis of genome-wide association studies for AL, combining 12,531 Europeans and 8,216 Asians. We identified eight genome-wide significant loci for AL (RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, and ALPPL2) and confirmed one previously reported AL locus (ZC3H11B). Of the nine loci, five (LAMA2, GJD2, CD55, ALPPL2, and ZC3H11B) were associated with refraction in 18 independent cohorts (n = 23,591). Differential gene expression was observed for these loci in minus-lens-induced myopia mouse experiments and human ocular tissues. Two of the AL genes, RSPO1 and ZNRF3, are involved in Wnt signaling, a pathway playing a major role in the regulation of eyeball size. This study provides evidence of shared genes between AL and refraction, but importantly also suggests that these traits may have unique pathways.
Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2013 Aug 8
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/03/15
revised 2013/04/17
accepted 2013/06/12
entrez 2013/10/23 06:00
pubmed 2013/10/23 06:00
medline 2013/12/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Cheng CY Cheng Ching-Yu CY Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.
Schache M Schache Maria M
Ikram MK Ikram M Kamran MK
Young TL Young Terri L TL
Guggenheim JA Guggenheim Jeremy A JA
Vitart V Vitart Veronique V
MacGregor S MacGregor Stuart S
Verhoeven VJ Verhoeven Virginie J M VJ
Barathi VA Barathi Veluchamy A VA
Liao J Liao Jiemin J
Hysi PG Hysi Pirro G PG
Bailey-Wilson JE Bailey-Wilson Joan E JE
St Pourcain B St Pourcain Beate B
Kemp JP Kemp John P JP
McMahon G McMahon George G
Timpson NJ Timpson Nicholas J NJ
Evans DM Evans David M DM
Montgomery GW Montgomery Grant W GW
Mishra A Mishra Aniket A
Wang YX Wang Ya Xing YX
Wang JJ Wang Jie Jin JJ
Rochtchina E Rochtchina Elena E
Polasek O Polasek Ozren O
Wright AF Wright Alan F AF
Amin N Amin Najaf N
van Leeuwen EM van Leeuwen Elisabeth M EM
Wilson JF Wilson James F JF
Pennell CE Pennell Craig E CE
van Duijn CM van Duijn Cornelia M CM
de Jong PT de Jong Paulus T V M PT
Vingerling JR Vingerling Johannes R JR
Zhou X Zhou Xin X
Chen P Chen Peng P
Li R Li Ruoying R
Tay WT Tay Wan-Ting WT
Zheng Y Zheng Yingfeng Y
Chew M Chew Merwyn M
Consortium for Refractive Error and Myopia
Burdon KP Burdon Kathryn P KP
Craig JE Craig Jamie E JE
Iyengar SK Iyengar Sudha K SK
Igo RP Jr Igo Robert P RP
Lass JH Jr Lass Jonathan H JH
Fuchs' Genetics Multi-Center Study Group
Chew EY Chew Emily Y EY
Haller T Haller Toomas T
Mihailov E Mihailov Evelin E
Metspalu A Metspalu Andres A
Wedenoja J Wedenoja Juho J
Simpson CL Simpson Claire L CL
Wojciechowski R Wojciechowski Robert R
Höhn R Höhn René R
Mirshahi A Mirshahi Alireza A
Zeller T Zeller Tanja T
Pfeiffer N Pfeiffer Norbert N
Lackner KJ Lackner Karl J KJ
Wellcome Trust Case Control Consortium 2
Bettecken T Bettecken Thomas T
Meitinger T Meitinger Thomas T
Oexle K Oexle Konrad K
Pirastu M Pirastu Mario M
Portas L Portas Laura L
Nag A Nag Abhishek A
Williams KM Williams Katie M KM
Yonova-Doing E Yonova-Doing Ekaterina E
Klein R Klein Ronald R
Klein BE Klein Barbara E BE
Hosseini SM Hosseini S Mohsen SM
Paterson AD Paterson Andrew D AD
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions, and Complications Research Group
Makela KM Makela Kari-Matti KM
Lehtimaki T Lehtimaki Terho T
Kahonen M Kahonen Mika M
Raitakari O Raitakari Olli O
Yoshimura N Yoshimura Nagahisa N
Matsuda F Matsuda Fumihiko F
Chen LJ Chen Li Jia LJ
Pang CP Pang Chi Pui CP
Yip SP Yip Shea Ping SP
Yap MK Yap Maurice K H MK
Meguro A Meguro Akira A
Mizuki N Mizuki Nobuhisa N
Inoko H Inoko Hidetoshi H
Foster PJ Foster Paul J PJ
Zhao JH Zhao Jing Hua JH
Vithana E Vithana Eranga E
Tai ES Tai E-Shyong ES
Fan Q Fan Qiao Q
Xu L Xu Liang L
Campbell H Campbell Harry H
Fleck B Fleck Brian B
Rudan I Rudan Igor I
Aung T Aung Tin T
Hofman A Hofman Albert A
Uitterlinden AG Uitterlinden André G AG
Bencic G Bencic Goran G
Khor CC Khor Chiea-Chuen CC
Forward H Forward Hannah H
Pärssinen O Pärssinen Olavi O
Mitchell P Mitchell Paul P
Rivadeneira F Rivadeneira Fernando F
Hewitt AW Hewitt Alex W AW
Williams C Williams Cathy C
Oostra BA Oostra Ben A BA
Teo YY Teo Yik-Ying YY
Hammond CJ Hammond Christopher J CJ
Stambolian D Stambolian Dwight D
Mackey DA Mackey David A DA
Klaver CC Klaver Caroline C W CC
Wong TY Wong Tien-Yin TY
Saw SM Saw Seang-Mei SM
Baird PN Baird Paul N PN
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Rahi Jugnoo S JS
Hysi Pirro G PG
Yoshimura Nagahisa N
Yamashiro Kenji K
Miyake Masahiro M
Delcourt Cécile C
Maubaret Cecilia C
Williams Cathy C
Guggenheim Jeremy A JA
Northstone Kate K
Ring Susan M SM
Davey-Smith George G
Craig Jamie E JE
Burdon Kathryn P KP
Fogarty Rhys D RD
Iyengar Sudha K SK
Igo Robert P RP
Chew Emily E
Janmahasathian Sarayut S
Iyengar Sudha K SK
Igo Robert P RP
Chew Emily E
Janmahasathian Sarayut S
Stambolian Dwight D
Bailey Wilson Joan E JE
MacGregor Stuart S
Lu Yi Y
Jonas Jost B JB
Xu Liang L
Saw Seang-Mei SM
Baird Paul N PN
Rochtchina Elena E
Mitchell Paul P
Wang Jie Jin JJ
Jonas Jost B JB
Nangia Vinay V
Hayward Caroline C
Wright Alan F AF
Vitart Veronique V
Polasek Ozren O
Campbell Harry H
Vitart Veronique V
Rudan Igor I
Vatavuk Zoran Z
Vitart Veronique V
Paterson Andrew D AD
Mohsen Hosseini S S
Iyengar Sudha K SK
Igo Robert P RP
Fondran Jeremy R JR
Young Terri L TL
Feng Sheng S
Verhoeven Virginie J M VJ
Klaver Caroline C CC
van Duijn Cornelia M CM
Metspalu Andres A
Haller Toomas T
Mihailov Evelin E
Pärssinen Olavi O
Wedenoja Juho J
Bailey Wilson Joan E JE
Wojciechowski Robert R
Baird Paul N PN
Schache Maria M
Pfeiffer Norbert N
Höhn René R
Pang Chi Pui CP
Chen Peng P
Meitinger Thomas T
Oexle Konrad K
Wegner Aharon A
Yoshimura Nagahisa N
Yamashiro Kenji K
Miyake Masahiro M
Pärssinen Olavi O
Yip Shea Ping SP
Ho Daniel W H DW
Pirastu Mario M
Murgia Federico F
Portas Laura L
Biino Genevra G
Wilson James F JF
Fleck Brian B
Vitart Veronique V
Stambolian Dwight D
Bailey Wilson Joan E JE
Hewitt Alex W AW
Ang Wei W
Verhoeven Virginie J M VJ
Klaver Caroline C CC
van Duijn Cornelia M CM
Saw Seang-Mei SM
Wong Tien-Yin TY
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Saw Seang-Mei SM
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Saw Seang-Mei SM
Wong Tien-Yin TY
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Saw Seang-Mei SM
Wong Tien-Yin TY
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Saw Seang-Mei SM
Tai E-Shyong ES
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Saw Seang-Mei SM
Teo Yik-Ying YY
Fan Qiao Q
Cheng Ching-Yu CY
Zhou Xin X
Kamran Ikram M M
Mackey David A DA
MacGregor Stuart S
Hammond Christopher J CJ
Hysi Pirro G PG
Deangelis Margaret M MM
Morrison Margaux M
Zhou Xiangtian X
Chen Wei W
Paterson Andrew D AD
Mohsen Hosseini S S
Mizuki Nobuhisa N
Meguro Akira A
Lehtimäki Terho T
Mäkelä Kari-Matti KM
Raitakari Olli O
Kähönen Mika M
Reinhart William W
Belin Michael W MW
Schultze Robert L RL
Morason Todd T
Sugar Alan A
Mian Shahzad S
Soong Hunson Kaz HK
Colby Kathryn K
Jurkunas Ula U
Yee Richard R
Vital Mark M
Alfonso Eduardo E
Karp Carol C
Lee Yunhee Y
Yoo Sonia S
Hammersmith Kristin K
Cohen Elisabeth E
Laibson Peter P
Rapuano Christopher C
Ayres Brandon B
Croasdale Christopher C
Caudill James J
Patel Sanjay S
Baratz Keith K
Bourne William W
Maguire Leo L
Sugar Joel J
Tu Elmer E
Djalilian Ali A
Mootha Vinod V
McCulley James J
Bowman Wayne W
Cavanaugh H Dwight HD
Verity Steven S
Verdier David D
Renucci Ann A
Oliva Matt M
Rotkis Walter W
Hardten David R DR
Fahmy Ahmad A
Brown Marlene M
Reeves Sherman S
Davis Elizabeth A EA
Lindstrom Richard R
Hauswirth Scott S
Hamilton Stephen S
Lee W Barry WB
Price Francis F
Price Marianne M
Kelly Kathleen K
Peters Faye F
Shaughnessy Michael M
Steinemann Thomas T
Dupps B J BJ
Meisler David M DM
Mifflin Mark M
Olson Randal R
Aldave Anthony A
Holland Gary G
Mondino Bartly J BJ
Rosenwasser George G
Gorovoy Mark M
Dunn Steven P SP
Heidemann David G DG
Terry Mark M
Shamie Neda N
Rosenfeld Steven I SI
Suedekum Brandon B
Hwang David D
Stone Donald D
Chodosh James J
Galentine Paul G PG
Bardenstein David D
Goddard Katrina K
Chin Hemin H
Mannis Mark M
Varma Rohit R
Borecki Ingrid I
Donnelly Peter P
Barroso Ines I
Blackwell Jenefer M JM
Bramon Elvira E
Brown Matthew A MA
Casas Juan P JP
Corvin Aiden A
Deloukas Panos P
Duncanson Audrey A
Jankowski Janusz J
Markus Hugh S HS
Mathew Christopher G CG
Palmer Colin N A CN
Plomin Robert R
Rautanen Anna A
Sawcer Stephen J SJ
Trembath Richard C RC
Viswanathan Ananth C AC
Wood Nicholas W NW
Spencer Chris C A CC
Band Gavin G
Bellenguez Céline C
Freeman Colin C
Hellenthal Garrett G
Giannoulatou Eleni E
Pirinen Matti M
Pearson Richard R
Strange Amy A
Su Zhan Z
Vukcevic Damjan D
Donnelly Peter P
Langford Cordelia C
Hunt Sarah E SE
Edkins Sarah S
Gwilliam Rhian R
Blackburn Hannah H
Bumpstead Suzannah J SJ
Dronov Serge S
Gillman Matthew M
Gray Emma E
Hammond Naomi N
Jayakumar Alagurevathi A
McCann Owen T OT
Liddle Jennifer J
Potter Simon C SC
Ravindrarajah Radhi R
Ricketts Michelle M
Waller Matthew M
Weston Paul P
Widaa Sara S
Whittaker Pamela P
Barroso Ines I
Deloukas Panos P
Mathew Christopher G CG
Blackwell Jenefer M JM
Brown Matthew A MA
Corvin Aiden A
Spencer Chris C A CC
Genuth S S
Nathan D M DM
Zinman B B
Crofford O O
Crandall J J
Reid M M
Brown-Friday J J
Engel S S
Sheindlin J J
Martinez H H
Shamoon H H
Engel H H
Phillips M M
Gubitosi-Klug R R
Mayer L L
Pendegast S S
Zegarra H H
Miller D D
Singerman L L
Smith-Brewer S S
Novak M M
Quin J J
Dahms W W
Genuth Saul S
Palmert M M
Brillon D D
Lackaye M E ME
Kiss S S
Chan R R
Reppucci V V
Lee T T
Heinemann M M
Whitehouse F F
Kruger D D
Jones J K JK
McLellan M M
Carey J D JD
Angus E E
Thomas A A
Galprin A A
Bergenstal R R
Johnson M M
Spencer M M
Morgan K K
Etzwiler D D
Kendall D D
Aiello Lloyd Paul LP
Golden E E
Jacobson A A
Beaser R R
Ganda O O
Hamdy O O
Wolpert H H
Sharuk G G
Arrigg P P
Schlossman D D
Rosenzwieg J J
Rand L L
Nathan D M DM
Larkin M M
Ong M M
Godine J J
Cagliero E E
Lou P P
Folino K K
Fritz S S
Crowell S S
Hansen K K
Gauthier-Kelly C C
Service J J
Ziegler G G
Luttrell L L
Caulder S S
Lopes-Virella M M
Colwell J J
Soule J J
Fernandes J J
Hermayer K K
Kwon S S
Brabham M M
Blevins A A
Parker J J
Lee D D
Patel N N
Pittman C C
Lindsey P P
Bracey M M
Lee K K
Nutaitis M M
Farr A A
Elsing S S
Thompson T T
Selby J J
Lyons T T
Yacoub-Wasef S S
Szpiech M M
Wood D D
Mayfield R R
Molitch M M
Schaefer B B
Jampol L L
Lyon A A
Gill M M
Strugula Z Z
Kaminski L L
Mirza R R
Simjanoski E E
Ryan D D
Kolterman O O
Lorenzi G G
Goldbaum M M
Sivitz W W
Bayless M M
Counts D D
Johnsonbaugh S S
Hebdon M M
Salemi P P
Liss R R
Donner T T
Gordon J J
Hemady R R
Kowarski A A
Ostrowski D D
Steidl S S
Jones B B
Herman W H WH
Martin C L CL
Pop-Busui R R
Sarma A A
Albers J J
Feldman E E
Kim K K
Elner S S
Comer G G
Gardner T T
Hackel R R
Prusak R R
Goings L L
Smith A A
Gothrup J J
Titus P P
Lee J J
Brandle M M
Prosser L L
Greene D A DA
Stevens M J MJ
Vine A K AK
Bantle J J
Wimmergren N N
Cochrane A A
Olsen T T
Steuer E E
Rath P P
Rogness B B
Hainsworth D D
Goldstein D D
Hitt S S
Giangiacomo J J
Schade D S DS
Canady J L JL
Chapin J E JE
Ketai C L H LH
Braunstein S S
Bourne P A PA
Schwartz S S
Brucker A A
Maschak-Carey B J BJ
Baker L L
Orchard T T
Silvers N N
Ryan C C
Songer T T
Doft B B
Olson S S
Bergren R L RL
Lobes L L
Paczan Rath P P
Becker D D
Rubinstein D D
Conrad P W PW
Yalamanchi S S
Drash A A
Morrison A A
Bernal M L ML
Vaccaro-Kish J J
Malone J J
Pavan P R PR
Grove N N
Iyer M N MN
Burrows A F AF
Tanaka E A EA
Gstalder R R
Dagogo-Jack S S
Wigley C C
Ricks H H
Kitabchi A A
Murphy M B MB
Moser S S
Meyer D D
Iannacone A A
Chaum E E
Yoser S S
Bryer-Ash M M
Schussler S S
Lambeth H H
Raskin P P
Strowig S S
Zinman B B
Barnie A A
Devenyi R R
Mandelcorn M M
Brent M M
Rogers S S
Gordon A A
Palmer J J
Catton S S
Brunzell J J
Wessells H H
de Boer I H IH
Hokanson J J
Purnell J J
Ginsberg J J
Kinyoun J J
Deeb S S
Weiss M M
Meekins G G
Distad J J
Van Ottingham L L
Dupre J J
Harth J J
Nicolle D D
Driscoll M M
Mahon J J
Canny C C
May M M
Lipps J J
Agarwal A A
Adkins T T
Survant L L
Pate R L RL
Munn G E GE
Lorenz R R
Feman S S
White N N
Levandoski L L
Boniuk I I
Grand G G
Thomas M M
Joseph D D DD
Blinder K K
Shah G G
Boniuk
Burgess
Santiago J J
Tamborlane W W
Gatcomb P P
Stoessel K K
Taylor K K
Goldstein J J
Novella S S
Mojibian H H
Cornfeld D D
Lima J J
Bluemke D D
Turkbey E E
van der Geest R J RJ
Liu C C
Malayeri A A
Jain A A
Miao C C
Chahal H H
Jarboe R R
Maynard J J
Gubitosi-Klug R R
Quin J J
Gaston P P
Palmert M M
Trail R R
Dahms W W
Lachin J J
Cleary P P
Backlund J J
Sun W W
Braffett B B
Klumpp K K
Chan K K
Diminick L L
Rosenberg D D
Petty B B
Determan A A
Kenny D D
Rutledge B B
Younes Naji N
Dews L L
Hawkins M M
Cowie C C
Fradkin J J
Siebert C C
Eastman R R
Danis R R
Gangaputra S S
Neill S S
Davis M M
Hubbard L L
Wabers H H
Burger M M
Dingledine J J
Gama V V
Sussman R R
Steffes M M
Bucksa J J
Nowicki M M
Chavers B B
O'Leary D D
Polak J J
Harrington A A
Funk L L
Crow R R
Gloeb B B
Thomas S S
O'Donnell C C
Soliman E E
Zhang Z M ZM
Prineas R R
Campbell C C
Ryan C C
Sandstrom D D
Williams T T
Geckle M M
Cupelli E E
Thoma F F
Burzuk B B
Woodfill T T
Low P P
Sommer C C
Nickander K K
Budoff M M
Detrano R R
Wong N N
Fox M M
Kim L L
Oudiz R R
Weir G G
Espeland M M
Manolio T T
Rand L L
Singer D D
Stern M M
Boulton A E AE
Clark C C
D'Agostino R R
Lopes-Virella M M
Garvey W T WT
Lyons T J TJ
Jenkins A A
Virella G G
Jaffa A A
Carter Rickey R
Lackland D D
Brabham M M
McGee D D
Zheng D D
Mayfield R K RK
Boright A A
Bull S S
Sun L L
Scherer S S
Zinman B B
Natarajan R R
Miao F F
Zhang L L
Chen Z Z
Nathan D M DM
JOURNAL
VOLUME: 93
ISSUE: 2
TITLE: American journal of human genetics
ISOABBREVIATION: Am. J. Hum. Genet.
YEAR: 2013
MONTH: Aug
DAY: 8
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1537-6605
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4846-53 17898312
Cites Vision Res. 2008 Mar;48(7):904-16 18289630
Cites Mol Biol Cell. 2008 Jun;19(6):2588-96 18400942
Cites Am J Ophthalmol. 2008 Jul;146(1):102-110 18455142
Cites Arch Ophthalmol. 2008 Aug;126(8):1091-9 18695104
Cites Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4336-9 18552384
Cites Int J Epidemiol. 2008 Dec;37(6):1220-6 18263651
Cites Vision Res. 2009 Feb;49(3):383-7 19059278
Cites PLoS One. 2009;4(5):e5472 19424496
Cites Arch Ophthalmol. 2009 May;127(5):649-55 19433716
Cites PLoS Genet. 2009 Jun;5(6):e1000529 19543373
Cites Nat Rev Genet. 2009 Oct;10(10):681-90 19763151
Cites Mol Vis. 2013;19:243-53 23401653
Cites Nat Genet. 2013 Mar;45(3):314-8 23396134
Cites Invest Ophthalmol Vis Sci. 2013 Mar;54(3):1715-21 23385790
Cites Int J Epidemiol. 2013 Feb;42(1):97-110 22507742
Cites Twin Res Hum Genet. 2009 Oct;12(5):441-54 19803772
Cites Invest Ophthalmol Vis Sci. 2002 May;43(5):1408-13 11980854
Cites BMJ. 2003 Sep 6;327(7414):557-60 12958120
Cites Ophthalmic Epidemiol. 2003 Oct;10(4):215-25 14628964
Cites Ophthalmology. 2004 Jan;111(1):62-9 14711715
Cites Ophthalmology. 2011 Sep;118(9):1798-804 21621261
Cites Eur J Epidemiol. 2011 Aug;26(8):657-86 21877163
Cites Invest Ophthalmol Vis Sci. 2011;52(12):8878-83 22003110
Cites Cornea. 2012 Jan;31(1):26-35 22045388
Cites Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 22064851
Cites Br J Ophthalmol. 2012 May;96(5):614-8 22133988
Cites Eye (Lond). 2012 May;26(5):684-9 22344187
Cites Nature. 2012 May 10;485(7397):195-200 22575959
Cites PLoS Genet. 2012;8(6):e1002753 22685421
Cites Hum Genet. 2012 Sep;131(9):1467-80 22665138
Cites Genome Res. 2012 Sep;22(9):1790-7 22955989
Cites Nat Genet. 2012 Oct;44(10):1142-6 22922875
Cites Nat Genet. 2013 Feb;45(2):155-63 23291589
Cites Int J Epidemiol. 2013 Feb;42(1):111-27 22507743
Cites Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6636-42 21791589
Cites Ophthalmic Epidemiol. 2009 Nov-Dec;16(6):325-36 19995197
Cites Invest Ophthalmol Vis Sci. 2010 Feb;51(2):737-43 19875653
Cites Ophthalmology. 2010 Jan;117(1):63-70 19880184
Cites Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1348-55 19933197
Cites Am J Hum Genet. 2010 Jul 9;87(1):139-45 20598278
Cites N Engl J Med. 2010 Sep 9;363(11):1016-24 20825314
Cites Nat Genet. 2010 Oct;42(10):897-901 20835239
Cites Ophthalmology. 2010 Oct;117(10):1908-11 20630598
Cites Hum Mol Genet. 2010 Nov 1;19(21):4304-11 20719862
Cites Surv Ophthalmol. 2010 Nov-Dec;55(6):561-83 20851442
Cites Genet Epidemiol. 2010 Dec;34(8):816-34 21058334
Cites Hum Mol Genet. 2011 Mar 1;20(5):1042-7 21149283
Cites PLoS Genet. 2011 Apr;7(4):e1001363 21490949
Cites Ophthalmology. 2011 May;118(5):797-804 21185080
Cites Nat Genet. 2011 Jun;43(6):574-8 21532571
Cites Methods Mol Biol. 2000;132:365-86 10547847
Cites Inflamm Res. 2000 Jun;49(6):290-6 10939619
Cites Invest Ophthalmol Vis Sci. 2001 May;42(6):1237-42 11328733
Cites Br J Ophthalmol. 2001 Dec;85(12):1470-6 11734523
Cites Physiol Genomics. 2001 Dec 21;7(2):179-86 11773604
Cites Ann Acad Med Singapore. 2004 Jan;33(1):27-33 15008558
Cites Eur J Hum Genet. 2004 Jul;12(7):527-34 15054401
Cites Surv Ophthalmol. 1980 May-Jun;24(Suppl):335-610 7444756
Cites N Engl J Med. 1993 Sep 30;329(14):977-86 8366922
Cites Lancet. 1993 Oct 9;342(8876):887-91 8105165
Cites Arch Ophthalmol. 1994 Dec;112(12):1526-30 7993206
Cites Early Hum Dev. 1996 Jul 19;45(3):203-14 8855394
Cites Ophthalmology. 1995 Oct;102(10):1450-60 9097791
Cites BMJ. 1997 Jun 28;314(7098):1864-8 9224128
Cites Invest Ophthalmol Vis Sci. 2005 Jan;46(1):51-7 15623754
Cites Hum Genet. 2005 Feb;116(3):152-9 15611866
Cites Ann Hum Genet. 2005 May;69(Pt 3):288-95 15845033
Cites Gesundheitswesen. 2005 Aug;67 Suppl 1:S19-25 16032513
Cites Gesundheitswesen. 2005 Aug;67 Suppl 1:S26-30 16032514
Cites Ophthalmic Physiol Opt. 2005 Sep;25(5):381-91 16101943
Cites Ophthalmology. 2005 Oct;112(10):1676-83 16111755
Cites Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4450-60 16303933
Cites Hum Hered. 2006;62(1):20-9 17003564
Cites Ophthalmology. 2006 Dec;113(12):2163-70 16996610
Cites Twin Res Hum Genet. 2006 Dec;9(6):899-906 17254428
Cites Ophthalmic Epidemiol. 2007 Jan-Feb;14(1):25-35 17365815
Cites Hum Genet. 2007 May;121(3-4):511-20 17205325
Cites Hum Mol Genet. 2007 Jun 15;16(12):1488-94 17478476
Cites Nat Genet. 2007 Jul;39(7):906-13 17572673
GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
092731 Wellcome Trust United Kingdom
CDF-2009-02-35 Department of Health United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
G9815508 Medical Research Council United Kingdom
K08 EY022943 NEI NIH HHS United States
MC_PC_15018 Medical Research Council United Kingdom
MC_PC_U127561128 Medical Research Council United Kingdom
MC_U127584475 Medical Research Council United Kingdom
MC_UU_12013/3 Medical Research Council United Kingdom
MR/K023721/1 Medical Research Council United Kingdom
R01 EY014685 NEI NIH HHS United States
R01 EY016379 NEI NIH HHS United States
R01 EY020483 NEI NIH HHS United States
R01 EY023196 NEI NIH HHS United States
SRF/01/010 Department of Health United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Asian Continental Ancestry Group
Axial Length, Eye pathology
European Continental Ancestry Group pathology
Eye Proteins metabolism
Female metabolism
Gene Expression metabolism
Genetic Loci metabolism
Genetic Predisposition to Disease metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Male metabolism
Middle Aged metabolism
Polymorphism, Single Nucleotide metabolism
Refractive Errors pathology
Signal Transduction pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Eye Proteins
OTHER ID's
OTHERID SOURCE
PMC3772747 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007