Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24141099
TITLE
Variation in Latent Classes of Adult Attention-Deficit Hyperactivity Disorder by Sex and Environmental Adversity.
ABSTRACT
Objective: The findings of genetic, imaging and neuropsychological studies of attention-deficit hyperactivity disorder (ADHD) are mixed. To understand why this might be the case we use both dimensional and categorical symptom measurement to provide alternate and detailed perspectives of symptom expression. Method: Interviewers collected ADHD, conduct problems (CP) and sociodemographic data from 3793 twins and their siblings aged 22 to 49 (M = 32.6). We estimate linear weighting of symptoms across ADHD and CP items. Latent class analyses and regression describe associations between measured variables, environmental risk factors and subsequent disadvantage. Additionally, the clinical relevance of each class was estimated. Results: Five classes were found for women and men; few symptoms, hyperactive-impulsive, CP, inattentive, combined symptoms with CP. Women within the inattentive class reported more symptoms and reduced emotional health when compared to men and to women within other latent classes. Women and men with combined ADHD symptoms reported comorbid conduct problems but those with either inattention or hyperactivity-impulsivity only did not. Conclusion: The dual perspective of dimensional and categorical measurement of ADHD provides important detail about symptom variation across sex and with environmental covariates. (J. of Att. Dis. 2013; XX(X) XX-XX).
DATE PUBLISHED
2013 Oct 18
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/10/22 06:00
pubmed 2013/10/22 06:00
medline 2013/10/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ebejer JL Ebejer Jane L JL
Medland SE Medland Sarah E SE
van der Werf J van der Werf Julius J
Lynskey M Lynskey Michael M
Martin NG Martin Nicholas G NG
Duffy DL Duffy David L DL
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Journal of attention disorders
ISOABBREVIATION: J Atten Disord
YEAR: 2013
MONTH: Oct
DAY: 18
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1557-1246
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Atten Disord
COUNTRY:
ISSNLINKING: 1087-0547
NLMUNIQUEID: 9615686
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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