Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24128737
TITLE
Genetic effects on the cerebellar role in working memory: same brain, different genes?
ABSTRACT
Over the past several years, evidence has accumulated showing that the cerebellum plays a significant role in cognitive function. Here we show, in a large genetically informative twin sample (n=430; aged 16-30years), that the cerebellum is strongly, and reliably (n=30 rescans), activated during an n-back working memory task, particularly lobules I-IV, VIIa Crus I and II, IX and the vermis. Monozygotic twin correlations for cerebellar activation were generally much larger than dizygotic twin correlations, consistent with genetic influences. Structural equation models showed that up to 65% of the variance in cerebellar activation during working memory is genetic (averaging 34% across significant voxels), most prominently in the lobules VI, and VIIa Crus I, with the remaining variance explained by unique/unshared environmental factors. Heritability estimates for brain activation in the cerebellum agree with those found for working memory activation in the cerebral cortex, even though cerebellar cyto-architecture differs substantially. Phenotypic correlations between BOLD percent signal change in cerebrum and cerebellum were low, and bivariate modeling indicated that genetic influences on the cerebellum are at least partly specific to the cerebellum. Activation on the voxel-level correlated very weakly with cerebellar gray matter volume, suggesting specific genetic influences on the BOLD signal. Heritable signals identified here should facilitate discovery of genetic polymorphisms influencing cerebellar function through genome-wide association studies, to elucidate the genetic liability to brain disorders affecting the cerebellum.
2013.
DATE PUBLISHED
2014 Feb 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/12/17
revised 2013/08/17
accepted 2013/10/07
aheadofprint 2013/10/12
entrez 2013/10/17 06:00
pubmed 2013/10/17 06:00
medline 2014/09/04 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Blokland GA Blokland Gabriëlla A M GA Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia. Electronic address: gabriella.blokland@uqconnect.edu.au.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Thompson PM Thompson Paul M PM Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Hickie IB Hickie Ian B IB Brain & Mind Research Institute, The University of Sydney, Sydney, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 86
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2014
MONTH: Feb
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Cerebellum
Functional MRI
Genetics
Heritability
Twin study
Working memory
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Cerebellum physiology
Female physiology
Genome, Human genetics
Humans genetics
Male genetics
Memory, Short-Term physiology
Nerve Net physiology
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS539569 NLM
PMC3925745 NLM