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| PMID |
|
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| TITLE |
|
| Genetic effects on the cerebellar role in working memory: same brain, different genes? |
|
| ABSTRACT |
|
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| Over the past several years, evidence has accumulated showing that the cerebellum plays a significant role in cognitive function. Here we show, in a large genetically informative twin sample (n=430; aged 16-30years), that the cerebellum is strongly, and reliably (n=30 rescans), activated during an n-back working memory task, particularly lobules I-IV, VIIa Crus I and II, IX and the vermis. Monozygotic twin correlations for cerebellar activation were generally much larger than dizygotic twin correlations, consistent with genetic influences. Structural equation models showed that up to 65% of the variance in cerebellar activation during working memory is genetic (averaging 34% across significant voxels), most prominently in the lobules VI, and VIIa Crus I, with the remaining variance explained by unique/unshared environmental factors. Heritability estimates for brain activation in the cerebellum agree with those found for working memory activation in the cerebral cortex, even though cerebellar cyto-architecture differs substantially. Phenotypic correlations between BOLD percent signal change in cerebrum and cerebellum were low, and bivariate modeling indicated that genetic influences on the cerebellum are at least partly specific to the cerebellum. Activation on the voxel-level correlated very weakly with cerebellar gray matter volume, suggesting specific genetic influences on the BOLD signal. Heritable signals identified here should facilitate discovery of genetic polymorphisms influencing cerebellar function through genome-wide association studies, to elucidate the genetic liability to brain disorders affecting the cerebellum. |
| © 2013. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2012/12/17 |
| revised |
2013/08/17 |
| accepted |
2013/10/07 |
| aheadofprint |
2013/10/12 |
| entrez |
2013/10/17 06:00 |
| pubmed |
2013/10/17 06:00 |
| medline |
2014/09/04 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Blokland GA |
|
Blokland |
Gabriëlla A M |
GA |
|
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia. Electronic address: gabriella.blokland@uqconnect.edu.au. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain & Mind Research Institute, The University of Sydney, Sydney, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology, University of Queensland, Brisbane, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia. |
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 86 |
| ISSUE: |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2014 |
| MONTH: Feb |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P41 EB015922 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Cerebellum |
| Functional MRI |
| Genetics |
| Heritability |
| Twin study |
| Working memory |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Cerebellum |
physiology |
| Female |
physiology |
| Genome, Human |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Memory, Short-Term |
physiology |
| Nerve Net |
physiology |
| Twins |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS539569 |
NLM |
| PMC3925745 |
NLM |
|
|
