|
|
| PMID |
|
|
| TITLE |
|
| Parental separation and early substance involvement: results from children of alcoholic and cannabis dependent twins. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Risks associated with parental separation have received limited attention in research on children of parents with substance use disorders. We examined early substance involvement as a function of parental separation during childhood and parental alcohol and cannabis dependence. |
| METHOD |
NlmCategory: METHODS |
| Data were drawn from 1318 adolescent offspring of monozygotic (MZ) or dizygotic (DZ) Australian twin parents. Cox proportional hazards regression analyses were conducted predicting age at first use of alcohol, first alcohol intoxication, first use and first regular use of cigarettes, and first use of cannabis, from parental separation and both parent and cotwin substance dependence. Parent and cotwin alcohol and cannabis dependence were initially modeled separately, with post hoc tests for equality of effects. |
| RESULTS |
NlmCategory: RESULTS |
| With few exceptions, risks associated with parental alcohol versus cannabis dependence could be equated, with results largely suggestive of genetic transmission of risk from parental substance (alcohol or cannabis) dependence broadly defined. Controlling for parental substance dependence, parental separation was a strong predictor for all substance use variables, especially through age 13. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| Together, findings underscore the importance of parental separation as a risk-factor for early substance involvement over and above both genetic and environmental influences specific to parental alcohol and cannabis dependence. |
| Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/06/01 |
| revised |
2013/09/04 |
| accepted |
2013/09/10 |
| aheadofprint |
2013/09/19 |
| entrez |
2013/10/15 06:00 |
| pubmed |
2013/10/15 06:00 |
| medline |
2014/08/17 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Waldron M |
|
Waldron |
Mary |
M |
|
Department of Counseling and Educational Psychology, Indiana University School of Education, Bloomington, IN, United States; Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. Electronic address: mwaldron@indiana.edu. |
| Grant JD |
|
Grant |
Julia D |
JD |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. |
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Addictions Department, Institute of Psychiatry, King's College, London, United Kingdom. |
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
Department of Psychology, University of Missouri, Columbia, MO, United States. |
| Glowinski AL |
|
Glowinski |
Anne L |
AL |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. |
| Henders A |
|
Henders |
Anjali |
A |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
Faculty of Arts and Business, University of the Sunshine Coast, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 134 |
| ISSUE: |
| TITLE: Drug and alcohol dependence |
| ISOABBREVIATION: Drug Alcohol Depend |
| YEAR: 2014 |
| MONTH: Jan |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1879-0046 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Drug Alcohol Depend |
| COUNTRY: Ireland |
| ISSNLINKING: 0376-8716 |
| NLMUNIQUEID: 7513587 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA010249 |
NIAAA NIH HHS |
United States |
| AA011998 |
NIAAA NIH HHS |
United States |
| AA015210 |
NIAAA NIH HHS |
United States |
| AA017688 |
NIAAA NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| DA023696 |
NIDA NIH HHS |
United States |
| DA14363 |
NIDA NIH HHS |
United States |
| K01 DA023696 |
NIDA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| P60 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA015210 |
NIAAA NIH HHS |
United States |
| R01 DA014363 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Adolescent substance use |
| Children of twins |
| Parental separation |
| Parental substance dependence |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Age Factors |
|
| Alcoholism |
psychology |
| Child |
psychology |
| Child of Impaired Parents |
psychology |
| Cohort Studies |
psychology |
| Divorce |
trends |
| Female |
trends |
| Humans |
trends |
| Male |
trends |
| Marijuana Abuse |
psychology |
| Risk Factors |
psychology |
| Twins |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS526041 |
NLM |
| PMC3908916 |
NLM |
|
|
