Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24108748
TITLE
Segmentation of high angular resolution diffusion MRI using sparse riemannian manifold clustering.
ABSTRACT
We address the problem of segmenting high angular resolution diffusion imaging (HARDI) data into multiple regions (or fiber tracts) with distinct diffusion properties. We use the orientation distribution function (ODF) to model diffusion and cast the ODF segmentation problem as a clustering problem in the space of ODFs. Our approach integrates tools from sparse representation theory and Riemannian geometry into a graph theoretic segmentation framework. By exploiting the Riemannian properties of the space of ODFs, we learn a sparse representation for each ODF and infer the segmentation by applying spectral clustering to a similarity matrix built from these representations. In cases where regions with similar (resp. distinct) diffusion properties belong to different (resp. same) fiber tracts, we obtain the segmentation by incorporating spatial and user-specified pairwise relationships into the formulation. Experiments on synthetic data evaluate the sensitivity of our method to image noise and to the concentration parameters, and show its superior performance compared to alternative methods when analyzing complex fiber configurations. Experiments on phantom and real data demonstrate the accuracy of the proposed method in segmenting simulated fibers and white matter fiber tracts of clinical importance.
DATE PUBLISHED
2014 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2013/10/03
entrez 2013/10/11 06:00
pubmed 2013/10/11 06:00
medline 2014/10/31 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Çetingül HE Çetingül H Ertan HE
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
Vidal R Vidal René R
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 2
TITLE: IEEE transactions on medical imaging
ISOABBREVIATION: IEEE Trans Med Imaging
YEAR: 2014
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1558-254X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: IEEE Trans Med Imaging
COUNTRY: United States
ISSNLINKING: 0278-0062
NLMUNIQUEID: 8310780
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Neuroimage. 2003 Jun;19(2 Pt 1):391-401 12814588
Cites IEEE Trans Pattern Anal Mach Intell. 2004 Feb;26(2):214-25 15376896
Cites J Magn Reson B. 1994 Mar;103(3):247-54 8019776
Cites Magn Reson Med. 2004 Dec;52(6):1358-72 15562495
Cites Med Image Anal. 2005 Jun;9(3):223-36 15854843
Cites IEEE Trans Med Imaging. 2005 Oct;24(10):1267-77 16229414
Cites Magn Reson Med. 2005 Dec;54(6):1377-86 16247738
Cites IEEE Trans Med Imaging. 2006 Jun;25(6):685-700 16768234
Cites Neuroimage. 2006 Aug 15;32(2):665-75 16815713
Cites Neuroimage. 2007 Jan 1;34(1):44-60 17035049
Cites Med Image Comput Comput Assist Interv. 2006;9(Pt 2):807-14 17354847
Cites Magn Reson Med. 2007 Sep;58(3):497-510 17763358
Cites IEEE Trans Pattern Anal Mach Intell. 2007 Nov;29(11):1944-57 17848776
Cites IEEE Trans Med Imaging. 2007 Nov;26(11):1464-71 18041262
Cites IEEE Trans Med Imaging. 2007 Nov;26(11):1547-54 18041269
Cites Med Image Comput Comput Assist Interv. 2008;11(Pt 1):1060-7 18979850
Cites Magn Reson Med. 2008 Dec;60(6):1276-83 19030160
Cites Magn Reson Med. 2009 Jan;61(1):205-14 19097208
Cites Neuroimage. 2009 Mar;45(1 Suppl):S111-22 19063977
Cites Neuroimage. 2009 Mar;45(1 Suppl):S153-62 19063978
Cites Neuroimage. 2009 Aug 15;47(2):638-50 19393321
Cites Med Image Comput Comput Assist Interv. 2009;12(Pt 1):877-85 20426071
Cites Med Image Comput Comput Assist Interv. 2009;12(Pt 1):911-8 20426075
Cites Magn Reson Med. 2010 Aug;64(2):554-66 20535807
Cites Neuroimage. 2011 Jan;54 Suppl 1:S146-64 20869453
Cites IEEE Trans Med Imaging. 2011 Feb;30(2):475-83 20952336
Cites Neuroimage. 2011 May 1;56(1):220-34 21256221
Cites Neuroimage. 2011 Jun 1;56(3):1181-201 21292013
Cites Neuroimage. 2007 May 1;35(4):1459-72 17379540
GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Algorithms
Brain physiology
Cluster Analysis physiology
Databases, Factual physiology
Diffusion Magnetic Resonance Imaging methods
Humans methods
Image Processing, Computer-Assisted methods
Models, Neurological methods
Phantoms, Imaging methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS653042 NLM
PMC4293082 NLM
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Last Modified: Oct 15 2007