|
|
| PMID |
|
|
| TITLE |
|
| Discovery and refinement of loci associated with lipid levels. |
|
| ABSTRACT |
|
|
|
| Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research. |
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| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2012/10/12 |
| accepted |
2013/09/13 |
| aheadofprint |
2013/10/06 |
| entrez |
2013/10/08 06:00 |
| pubmed |
2013/10/08 06:00 |
| medline |
2014/01/09 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
|
Global Lipids Genetics Consortium |
|
|
|
|
1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [3] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. [4] Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. [5] [6]. |
| Willer CJ |
|
Willer |
Cristen J |
CJ |
|
|
| Schmidt EM |
|
Schmidt |
Ellen M |
EM |
|
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| Sengupta S |
|
Sengupta |
Sebanti |
S |
|
|
| Peloso GM |
|
Peloso |
Gina M |
GM |
|
|
| Gustafsson S |
|
Gustafsson |
Stefan |
S |
|
|
| Kanoni S |
|
Kanoni |
Stavroula |
S |
|
|
| Ganna A |
|
Ganna |
Andrea |
A |
|
|
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|
Chen |
Jin |
J |
|
|
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|
Buchkovich |
Martin L |
ML |
|
|
| Mora S |
|
Mora |
Samia |
S |
|
|
| Beckmann JS |
|
Beckmann |
Jacques S |
JS |
|
|
| Bragg-Gresham JL |
|
Bragg-Gresham |
Jennifer L |
JL |
|
|
| Chang HY |
|
Chang |
Hsing-Yi |
HY |
|
|
| Demirkan A |
|
Demirkan |
Ayşe |
A |
|
|
| Den Hertog HM |
|
Den Hertog |
Heleen M |
HM |
|
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| Do R |
|
Do |
Ron |
R |
|
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| Donnelly LA |
|
Donnelly |
Louise A |
LA |
|
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| Ehret GB |
|
Ehret |
Georg B |
GB |
|
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| Esko T |
|
Esko |
Tõnu |
T |
|
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| Feitosa MF |
|
Feitosa |
Mary F |
MF |
|
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| Ferreira T |
|
Ferreira |
Teresa |
T |
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| Fischer K |
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Fischer |
Krista |
K |
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|
Fontanillas |
Pierre |
P |
|
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| Fraser RM |
|
Fraser |
Ross M |
RM |
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| Freitag DF |
|
Freitag |
Daniel F |
DF |
|
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| Gurdasani D |
|
Gurdasani |
Deepti |
D |
|
|
| Heikkilä K |
|
Heikkilä |
Kauko |
K |
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| Hyppönen E |
|
Hyppönen |
Elina |
E |
|
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| Isaacs A |
|
Isaacs |
Aaron |
A |
|
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|
Jackson |
Anne U |
AU |
|
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| Johansson A |
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Johansson |
Asa |
A |
|
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Johnson |
Toby |
T |
|
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Kaakinen |
Marika |
M |
|
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|
Kettunen |
Johannes |
J |
|
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|
Kleber |
Marcus E |
ME |
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|
Li |
Xiaohui |
X |
|
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|
Luan |
Jian'an |
J |
|
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| Lyytikäinen LP |
|
Lyytikäinen |
Leo-Pekka |
LP |
|
|
| Magnusson PK |
|
Magnusson |
Patrik K E |
PK |
|
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|
Mangino |
Massimo |
M |
|
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|
Mihailov |
Evelin |
E |
|
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|
Montasser |
May E |
ME |
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|
Müller-Nurasyid |
Martina |
M |
|
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|
Nolte |
Ilja M |
IM |
|
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| O'Connell JR |
|
O'Connell |
Jeffrey R |
JR |
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| Palmer CD |
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Palmer |
Cameron D |
CD |
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|
Perola |
Markus |
M |
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| Petersen AK |
|
Petersen |
Ann-Kristin |
AK |
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| Sanna S |
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Sanna |
Serena |
S |
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| Saxena R |
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Saxena |
Richa |
R |
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| Service SK |
|
Service |
Susan K |
SK |
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| Shah S |
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Shah |
Sonia |
S |
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| Shungin D |
|
Shungin |
Dmitry |
D |
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|
Sidore |
Carlo |
C |
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|
Song |
Ci |
C |
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| Strawbridge RJ |
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Strawbridge |
Rona J |
RJ |
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| Surakka I |
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Surakka |
Ida |
I |
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Tanaka |
Toshiko |
T |
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|
Teslovich |
Tanya M |
TM |
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Thorleifsson |
Gudmar |
G |
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| Van den Herik EG |
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Van den Herik |
Evita G |
EG |
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| Voight BF |
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Voight |
Benjamin F |
BF |
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| Volcik KA |
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Volcik |
Kelly A |
KA |
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| Waite LL |
|
Waite |
Lindsay L |
LL |
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| Wong A |
|
Wong |
Andrew |
A |
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| Wu Y |
|
Wu |
Ying |
Y |
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| Zhang W |
|
Zhang |
Weihua |
W |
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| Absher D |
|
Absher |
Devin |
D |
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| Asiki G |
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Asiki |
Gershim |
G |
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| Barroso I |
|
Barroso |
Inês |
I |
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| Been LF |
|
Been |
Latonya F |
LF |
|
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| Bolton JL |
|
Bolton |
Jennifer L |
JL |
|
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| Bonnycastle LL |
|
Bonnycastle |
Lori L |
LL |
|
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| Brambilla P |
|
Brambilla |
Paolo |
P |
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| Burnett MS |
|
Burnett |
Mary S |
MS |
|
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| Cesana G |
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Cesana |
Giancarlo |
G |
|
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| Dimitriou M |
|
Dimitriou |
Maria |
M |
|
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| Doney AS |
|
Doney |
Alex S F |
AS |
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| Döring A |
|
Döring |
Angela |
A |
|
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| Elliott P |
|
Elliott |
Paul |
P |
|
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| Epstein SE |
|
Epstein |
Stephen E |
SE |
|
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| Eyjolfsson GI |
|
Eyjolfsson |
Gudmundur Ingi |
GI |
|
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| Gigante B |
|
Gigante |
Bruna |
B |
|
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| Goodarzi MO |
|
Goodarzi |
Mark O |
MO |
|
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| Grallert H |
|
Grallert |
Harald |
H |
|
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| Gravito ML |
|
Gravito |
Martha L |
ML |
|
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| Groves CJ |
|
Groves |
Christopher J |
CJ |
|
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| Hallmans G |
|
Hallmans |
Göran |
G |
|
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| Hartikainen AL |
|
Hartikainen |
Anna-Liisa |
AL |
|
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| Hayward C |
|
Hayward |
Caroline |
C |
|
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| Hernandez D |
|
Hernandez |
Dena |
D |
|
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| Hicks AA |
|
Hicks |
Andrew A |
AA |
|
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| Holm H |
|
Holm |
Hilma |
H |
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| Hung YJ |
|
Hung |
Yi-Jen |
YJ |
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| Illig T |
|
Illig |
Thomas |
T |
|
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| Jones MR |
|
Jones |
Michelle R |
MR |
|
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| Kaleebu P |
|
Kaleebu |
Pontiano |
P |
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| Kastelein JJ |
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Kastelein |
John J P |
JJ |
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| Khaw KT |
|
Khaw |
Kay-Tee |
KT |
|
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| Kim E |
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Kim |
Eric |
E |
|
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| Klopp N |
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Klopp |
Norman |
N |
|
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| Komulainen P |
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Komulainen |
Pirjo |
P |
|
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|
Kumari |
Meena |
M |
|
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|
Langenberg |
Claudia |
C |
|
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| Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
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| Lin SY |
|
Lin |
Shih-Yi |
SY |
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| Lindström J |
|
Lindström |
Jaana |
J |
|
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| Loos RJ |
|
Loos |
Ruth J F |
RJ |
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| Mach F |
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Mach |
François |
F |
|
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| McArdle WL |
|
McArdle |
Wendy L |
WL |
|
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| Meisinger C |
|
Meisinger |
Christa |
C |
|
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| Mitchell BD |
|
Mitchell |
Braxton D |
BD |
|
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| Müller G |
|
Müller |
Gabrielle |
G |
|
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| Nagaraja R |
|
Nagaraja |
Ramaiah |
R |
|
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| Narisu N |
|
Narisu |
Narisu |
N |
|
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| Nieminen TV |
|
Nieminen |
Tuomo V M |
TV |
|
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| Nsubuga RN |
|
Nsubuga |
Rebecca N |
RN |
|
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| Olafsson I |
|
Olafsson |
Isleifur |
I |
|
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| Ong KK |
|
Ong |
Ken K |
KK |
|
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| Palotie A |
|
Palotie |
Aarno |
A |
|
|
| Papamarkou T |
|
Papamarkou |
Theodore |
T |
|
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| Pomilla C |
|
Pomilla |
Cristina |
C |
|
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| Pouta A |
|
Pouta |
Anneli |
A |
|
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| Rader DJ |
|
Rader |
Daniel J |
DJ |
|
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| Reilly MP |
|
Reilly |
Muredach P |
MP |
|
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| Ridker PM |
|
Ridker |
Paul M |
PM |
|
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|
Rivadeneira |
Fernando |
F |
|
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|
Rudan |
Igor |
I |
|
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|
Ruokonen |
Aimo |
A |
|
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|
Samani |
Nilesh |
N |
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Scharnagl |
Hubert |
H |
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Seeley |
Janet |
J |
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Silander |
Kaisa |
K |
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Stancáková |
Alena |
A |
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Stirrups |
Kathleen |
K |
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|
Swift |
Amy J |
AJ |
|
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|
Tiret |
Laurence |
L |
|
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|
Uitterlinden |
Andre G |
AG |
|
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| van Pelt LJ |
|
van Pelt |
L Joost |
LJ |
|
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| Vedantam S |
|
Vedantam |
Sailaja |
S |
|
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|
Wainwright |
Nicholas |
N |
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Wijmenga |
Cisca |
C |
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|
Wild |
Sarah H |
SH |
|
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Willemsen |
Gonneke |
G |
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|
Wilsgaard |
Tom |
T |
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|
Wilson |
James F |
JF |
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| Young EH |
|
Young |
Elizabeth H |
EH |
|
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| Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
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| Adair LS |
|
Adair |
Linda S |
LS |
|
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| Arveiler D |
|
Arveiler |
Dominique |
D |
|
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| Assimes TL |
|
Assimes |
Themistocles L |
TL |
|
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| Bandinelli S |
|
Bandinelli |
Stefania |
S |
|
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| Bennett F |
|
Bennett |
Franklyn |
F |
|
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| Bochud M |
|
Bochud |
Murielle |
M |
|
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| Boehm BO |
|
Boehm |
Bernhard O |
BO |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
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| Borecki IB |
|
Borecki |
Ingrid B |
IB |
|
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| Bornstein SR |
|
Bornstein |
Stefan R |
SR |
|
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| Bovet P |
|
Bovet |
Pascal |
P |
|
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| Burnier M |
|
Burnier |
Michel |
M |
|
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| Campbell H |
|
Campbell |
Harry |
H |
|
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| Chakravarti A |
|
Chakravarti |
Aravinda |
A |
|
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| Chambers JC |
|
Chambers |
John C |
JC |
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| Chen YD |
|
Chen |
Yii-Der Ida |
YD |
|
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| Collins FS |
|
Collins |
Francis S |
FS |
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| Cooper RS |
|
Cooper |
Richard S |
RS |
|
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|
Danesh |
John |
J |
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|
Dedoussis |
George |
G |
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| de Faire U |
|
de Faire |
Ulf |
U |
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| Feranil AB |
|
Feranil |
Alan B |
AB |
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| Ferrières J |
|
Ferrières |
Jean |
J |
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|
Ferrucci |
Luigi |
L |
|
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| Freimer NB |
|
Freimer |
Nelson B |
NB |
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| Gieger C |
|
Gieger |
Christian |
C |
|
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| Groop LC |
|
Groop |
Leif C |
LC |
|
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| Gudnason V |
|
Gudnason |
Vilmundur |
V |
|
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| Gyllensten U |
|
Gyllensten |
Ulf |
U |
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| Hamsten A |
|
Hamsten |
Anders |
A |
|
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| Harris TB |
|
Harris |
Tamara B |
TB |
|
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| Hingorani A |
|
Hingorani |
Aroon |
A |
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| Hirschhorn JN |
|
Hirschhorn |
Joel N |
JN |
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| Hofman A |
|
Hofman |
Albert |
A |
|
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| Hovingh GK |
|
Hovingh |
G Kees |
GK |
|
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| Hsiung CA |
|
Hsiung |
Chao Agnes |
CA |
|
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| Humphries SE |
|
Humphries |
Steve E |
SE |
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| Hunt SC |
|
Hunt |
Steven C |
SC |
|
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| Hveem K |
|
Hveem |
Kristian |
K |
|
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| Iribarren C |
|
Iribarren |
Carlos |
C |
|
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| Järvelin MR |
|
Järvelin |
Marjo-Riitta |
MR |
|
|
| Jula A |
|
Jula |
Antti |
A |
|
|
| Kähönen M |
|
Kähönen |
Mika |
M |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
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| Kesäniemi A |
|
Kesäniemi |
Antero |
A |
|
|
| Kivimaki M |
|
Kivimaki |
Mika |
M |
|
|
| Kooner JS |
|
Kooner |
Jaspal S |
JS |
|
|
| Koudstaal PJ |
|
Koudstaal |
Peter J |
PJ |
|
|
| Krauss RM |
|
Krauss |
Ronald M |
RM |
|
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| Kuh D |
|
Kuh |
Diana |
D |
|
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| Kuusisto J |
|
Kuusisto |
Johanna |
J |
|
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| Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
|
|
| Laakso M |
|
Laakso |
Markku |
M |
|
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| Lakka TA |
|
Lakka |
Timo A |
TA |
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| Lind L |
|
Lind |
Lars |
L |
|
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| Lindgren CM |
|
Lindgren |
Cecilia M |
CM |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
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| März W |
|
März |
Winfried |
W |
|
|
| McCarthy MI |
|
McCarthy |
Mark I |
MI |
|
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| McKenzie CA |
|
McKenzie |
Colin A |
CA |
|
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| Meneton P |
|
Meneton |
Pierre |
P |
|
|
| Metspalu A |
|
Metspalu |
Andres |
A |
|
|
| Moilanen L |
|
Moilanen |
Leena |
L |
|
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| Morris AD |
|
Morris |
Andrew D |
AD |
|
|
| Munroe PB |
|
Munroe |
Patricia B |
PB |
|
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| Njølstad I |
|
Njølstad |
Inger |
I |
|
|
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
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| Power C |
|
Power |
Chris |
C |
|
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| Pramstaller PP |
|
Pramstaller |
Peter P |
PP |
|
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| Price JF |
|
Price |
Jackie F |
JF |
|
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| Psaty BM |
|
Psaty |
Bruce M |
BM |
|
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| Quertermous T |
|
Quertermous |
Thomas |
T |
|
|
| Rauramaa R |
|
Rauramaa |
Rainer |
R |
|
|
| Saleheen D |
|
Saleheen |
Danish |
D |
|
|
| Salomaa V |
|
Salomaa |
Veikko |
V |
|
|
| Sanghera DK |
|
Sanghera |
Dharambir K |
DK |
|
|
| Saramies J |
|
Saramies |
Jouko |
J |
|
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| Schwarz PE |
|
Schwarz |
Peter E H |
PE |
|
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| Sheu WH |
|
Sheu |
Wayne H-H |
WH |
|
|
| Shuldiner AR |
|
Shuldiner |
Alan R |
AR |
|
|
| Siegbahn A |
|
Siegbahn |
Agneta |
A |
|
|
| Spector TD |
|
Spector |
Tim D |
TD |
|
|
| Stefansson K |
|
Stefansson |
Kari |
K |
|
|
| Strachan DP |
|
Strachan |
David P |
DP |
|
|
| Tayo BO |
|
Tayo |
Bamidele O |
BO |
|
|
| Tremoli E |
|
Tremoli |
Elena |
E |
|
|
| Tuomilehto J |
|
Tuomilehto |
Jaakko |
J |
|
|
| Uusitupa M |
|
Uusitupa |
Matti |
M |
|
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| van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
|
| Vollenweider P |
|
Vollenweider |
Peter |
P |
|
|
| Wallentin L |
|
Wallentin |
Lars |
L |
|
|
| Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
|
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
|
| Wolffenbuttel BH |
|
Wolffenbuttel |
Bruce H R |
BH |
|
|
| Ordovas JM |
|
Ordovas |
Jose M |
JM |
|
|
| Boerwinkle E |
|
Boerwinkle |
Eric |
E |
|
|
| Palmer CN |
|
Palmer |
Colin N A |
CN |
|
|
| Thorsteinsdottir U |
|
Thorsteinsdottir |
Unnur |
U |
|
|
| Chasman DI |
|
Chasman |
Daniel I |
DI |
|
|
| Rotter JI |
|
Rotter |
Jerome I |
JI |
|
|
| Franks PW |
|
Franks |
Paul W |
PW |
|
|
| Ripatti S |
|
Ripatti |
Samuli |
S |
|
|
| Cupples LA |
|
Cupples |
L Adrienne |
LA |
|
|
| Sandhu MS |
|
Sandhu |
Manjinder S |
MS |
|
|
| Rich SS |
|
Rich |
Stephen S |
SS |
|
|
| Boehnke M |
|
Boehnke |
Michael |
M |
|
|
| Deloukas P |
|
Deloukas |
Panos |
P |
|
|
| Kathiresan S |
|
Kathiresan |
Sekar |
S |
|
|
| Mohlke KL |
|
Mohlke |
Karen L |
KL |
|
|
| Ingelsson E |
|
Ingelsson |
Erik |
E |
|
|
| Abecasis GR |
|
Abecasis |
Gonçalo R |
GR |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 45 |
| ISSUE: 11 |
| TITLE: Nature genetics |
| ISOABBREVIATION: Nat. Genet. |
| YEAR: 2013 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1546-1718 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Nat Genet |
| COUNTRY: United States |
| ISSNLINKING: 1061-4036 |
| NLMUNIQUEID: 9216904 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 090532 |
Wellcome Trust |
United Kingdom |
| CZB/4/672 |
Chief Scientist Office |
United Kingdom |
| CZB/4/710 |
Chief Scientist Office |
United Kingdom |
| G0801566 |
Medical Research Council |
United Kingdom |
| G0901213 |
Medical Research Council |
United Kingdom |
| G1000143 |
Medical Research Council |
United Kingdom |
| MC_U106179471 |
Medical Research Council |
United Kingdom |
| MC_U106179472 |
Medical Research Council |
United Kingdom |
| MC_U106188470 |
Medical Research Council |
United Kingdom |
| MC_U123092720 |
Medical Research Council |
United Kingdom |
| MC_U950080926 |
Medical Research Council |
United Kingdom |
| MR/K013351/1 |
Medical Research Council |
United Kingdom |
| MR/L003120/1 |
Medical Research Council |
United Kingdom |
| P30 DK063491 |
NIDDK NIH HHS |
United States |
| P60 DK020541 |
NIDDK NIH HHS |
United States |
| PG/08/094/26019 |
British Heart Foundation |
United Kingdom |
| R00 HL094535 |
NHLBI NIH HHS |
United States |
| R01 DK072193 |
NIDDK NIH HHS |
United States |
| R01 HL105756 |
NHLBI NIH HHS |
United States |
| R01 HL109946 |
NHLBI NIH HHS |
United States |
| RG/08/008/25291 |
British Heart Foundation |
United Kingdom |
| RG/08/014/24067 |
British Heart Foundation |
United Kingdom |
| U01 HL069757 |
NHLBI NIH HHS |
United States |
| UL1 TR000124 |
NCATS NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| African Continental Ancestry Group |
genetics |
| Asian Continental Ancestry Group |
genetics |
| Cholesterol, HDL |
genetics |
| Cholesterol, LDL |
genetics |
| Coronary Artery Disease |
genetics |
| European Continental Ancestry Group |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Lipids |
genetics |
| Triglycerides |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Cholesterol, HDL |
| 0 |
Cholesterol, LDL |
| 0 |
Lipids |
| 0 |
Triglycerides |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS524703 |
NLM |
| PMC3838666 |
NLM |
|
|
