Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24097068
TITLE
Discovery and refinement of loci associated with lipid levels.
ABSTRACT
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
DATE PUBLISHED
2013 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/10/12
accepted 2013/09/13
aheadofprint 2013/10/06
entrez 2013/10/08 06:00
pubmed 2013/10/08 06:00
medline 2014/01/09 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Global Lipids Genetics Consortium 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [3] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. [4] Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. [5] [6].
Willer CJ Willer Cristen J CJ
Schmidt EM Schmidt Ellen M EM
Sengupta S Sengupta Sebanti S
Peloso GM Peloso Gina M GM
Gustafsson S Gustafsson Stefan S
Kanoni S Kanoni Stavroula S
Ganna A Ganna Andrea A
Chen J Chen Jin J
Buchkovich ML Buchkovich Martin L ML
Mora S Mora Samia S
Beckmann JS Beckmann Jacques S JS
Bragg-Gresham JL Bragg-Gresham Jennifer L JL
Chang HY Chang Hsing-Yi HY
Demirkan A Demirkan Ayşe A
Den Hertog HM Den Hertog Heleen M HM
Do R Do Ron R
Donnelly LA Donnelly Louise A LA
Ehret GB Ehret Georg B GB
Esko T Esko Tõnu T
Feitosa MF Feitosa Mary F MF
Ferreira T Ferreira Teresa T
Fischer K Fischer Krista K
Fontanillas P Fontanillas Pierre P
Fraser RM Fraser Ross M RM
Freitag DF Freitag Daniel F DF
Gurdasani D Gurdasani Deepti D
Heikkilä K Heikkilä Kauko K
Hyppönen E Hyppönen Elina E
Isaacs A Isaacs Aaron A
Jackson AU Jackson Anne U AU
Johansson A Johansson Asa A
Johnson T Johnson Toby T
Kaakinen M Kaakinen Marika M
Kettunen J Kettunen Johannes J
Kleber ME Kleber Marcus E ME
Li X Li Xiaohui X
Luan J Luan Jian'an J
Lyytikäinen LP Lyytikäinen Leo-Pekka LP
Magnusson PK Magnusson Patrik K E PK
Mangino M Mangino Massimo M
Mihailov E Mihailov Evelin E
Montasser ME Montasser May E ME
Müller-Nurasyid M Müller-Nurasyid Martina M
Nolte IM Nolte Ilja M IM
O'Connell JR O'Connell Jeffrey R JR
Palmer CD Palmer Cameron D CD
Perola M Perola Markus M
Petersen AK Petersen Ann-Kristin AK
Sanna S Sanna Serena S
Saxena R Saxena Richa R
Service SK Service Susan K SK
Shah S Shah Sonia S
Shungin D Shungin Dmitry D
Sidore C Sidore Carlo C
Song C Song Ci C
Strawbridge RJ Strawbridge Rona J RJ
Surakka I Surakka Ida I
Tanaka T Tanaka Toshiko T
Teslovich TM Teslovich Tanya M TM
Thorleifsson G Thorleifsson Gudmar G
Van den Herik EG Van den Herik Evita G EG
Voight BF Voight Benjamin F BF
Volcik KA Volcik Kelly A KA
Waite LL Waite Lindsay L LL
Wong A Wong Andrew A
Wu Y Wu Ying Y
Zhang W Zhang Weihua W
Absher D Absher Devin D
Asiki G Asiki Gershim G
Barroso I Barroso Inês I
Been LF Been Latonya F LF
Bolton JL Bolton Jennifer L JL
Bonnycastle LL Bonnycastle Lori L LL
Brambilla P Brambilla Paolo P
Burnett MS Burnett Mary S MS
Cesana G Cesana Giancarlo G
Dimitriou M Dimitriou Maria M
Doney AS Doney Alex S F AS
Döring A Döring Angela A
Elliott P Elliott Paul P
Epstein SE Epstein Stephen E SE
Eyjolfsson GI Eyjolfsson Gudmundur Ingi GI
Gigante B Gigante Bruna B
Goodarzi MO Goodarzi Mark O MO
Grallert H Grallert Harald H
Gravito ML Gravito Martha L ML
Groves CJ Groves Christopher J CJ
Hallmans G Hallmans Göran G
Hartikainen AL Hartikainen Anna-Liisa AL
Hayward C Hayward Caroline C
Hernandez D Hernandez Dena D
Hicks AA Hicks Andrew A AA
Holm H Holm Hilma H
Hung YJ Hung Yi-Jen YJ
Illig T Illig Thomas T
Jones MR Jones Michelle R MR
Kaleebu P Kaleebu Pontiano P
Kastelein JJ Kastelein John J P JJ
Khaw KT Khaw Kay-Tee KT
Kim E Kim Eric E
Klopp N Klopp Norman N
Komulainen P Komulainen Pirjo P
Kumari M Kumari Meena M
Langenberg C Langenberg Claudia C
Lehtimäki T Lehtimäki Terho T
Lin SY Lin Shih-Yi SY
Lindström J Lindström Jaana J
Loos RJ Loos Ruth J F RJ
Mach F Mach François F
McArdle WL McArdle Wendy L WL
Meisinger C Meisinger Christa C
Mitchell BD Mitchell Braxton D BD
Müller G Müller Gabrielle G
Nagaraja R Nagaraja Ramaiah R
Narisu N Narisu Narisu N
Nieminen TV Nieminen Tuomo V M TV
Nsubuga RN Nsubuga Rebecca N RN
Olafsson I Olafsson Isleifur I
Ong KK Ong Ken K KK
Palotie A Palotie Aarno A
Papamarkou T Papamarkou Theodore T
Pomilla C Pomilla Cristina C
Pouta A Pouta Anneli A
Rader DJ Rader Daniel J DJ
Reilly MP Reilly Muredach P MP
Ridker PM Ridker Paul M PM
Rivadeneira F Rivadeneira Fernando F
Rudan I Rudan Igor I
Ruokonen A Ruokonen Aimo A
Samani N Samani Nilesh N
Scharnagl H Scharnagl Hubert H
Seeley J Seeley Janet J
Silander K Silander Kaisa K
Stancáková A Stancáková Alena A
Stirrups K Stirrups Kathleen K
Swift AJ Swift Amy J AJ
Tiret L Tiret Laurence L
Uitterlinden AG Uitterlinden Andre G AG
van Pelt LJ van Pelt L Joost LJ
Vedantam S Vedantam Sailaja S
Wainwright N Wainwright Nicholas N
Wijmenga C Wijmenga Cisca C
Wild SH Wild Sarah H SH
Willemsen G Willemsen Gonneke G
Wilsgaard T Wilsgaard Tom T
Wilson JF Wilson James F JF
Young EH Young Elizabeth H EH
Zhao JH Zhao Jing Hua JH
Adair LS Adair Linda S LS
Arveiler D Arveiler Dominique D
Assimes TL Assimes Themistocles L TL
Bandinelli S Bandinelli Stefania S
Bennett F Bennett Franklyn F
Bochud M Bochud Murielle M
Boehm BO Boehm Bernhard O BO
Boomsma DI Boomsma Dorret I DI
Borecki IB Borecki Ingrid B IB
Bornstein SR Bornstein Stefan R SR
Bovet P Bovet Pascal P
Burnier M Burnier Michel M
Campbell H Campbell Harry H
Chakravarti A Chakravarti Aravinda A
Chambers JC Chambers John C JC
Chen YD Chen Yii-Der Ida YD
Collins FS Collins Francis S FS
Cooper RS Cooper Richard S RS
Danesh J Danesh John J
Dedoussis G Dedoussis George G
de Faire U de Faire Ulf U
Feranil AB Feranil Alan B AB
Ferrières J Ferrières Jean J
Ferrucci L Ferrucci Luigi L
Freimer NB Freimer Nelson B NB
Gieger C Gieger Christian C
Groop LC Groop Leif C LC
Gudnason V Gudnason Vilmundur V
Gyllensten U Gyllensten Ulf U
Hamsten A Hamsten Anders A
Harris TB Harris Tamara B TB
Hingorani A Hingorani Aroon A
Hirschhorn JN Hirschhorn Joel N JN
Hofman A Hofman Albert A
Hovingh GK Hovingh G Kees GK
Hsiung CA Hsiung Chao Agnes CA
Humphries SE Humphries Steve E SE
Hunt SC Hunt Steven C SC
Hveem K Hveem Kristian K
Iribarren C Iribarren Carlos C
Järvelin MR Järvelin Marjo-Riitta MR
Jula A Jula Antti A
Kähönen M Kähönen Mika M
Kaprio J Kaprio Jaakko J
Kesäniemi A Kesäniemi Antero A
Kivimaki M Kivimaki Mika M
Kooner JS Kooner Jaspal S JS
Koudstaal PJ Koudstaal Peter J PJ
Krauss RM Krauss Ronald M RM
Kuh D Kuh Diana D
Kuusisto J Kuusisto Johanna J
Kyvik KO Kyvik Kirsten O KO
Laakso M Laakso Markku M
Lakka TA Lakka Timo A TA
Lind L Lind Lars L
Lindgren CM Lindgren Cecilia M CM
Martin NG Martin Nicholas G NG
März W März Winfried W
McCarthy MI McCarthy Mark I MI
McKenzie CA McKenzie Colin A CA
Meneton P Meneton Pierre P
Metspalu A Metspalu Andres A
Moilanen L Moilanen Leena L
Morris AD Morris Andrew D AD
Munroe PB Munroe Patricia B PB
Njølstad I Njølstad Inger I
Pedersen NL Pedersen Nancy L NL
Power C Power Chris C
Pramstaller PP Pramstaller Peter P PP
Price JF Price Jackie F JF
Psaty BM Psaty Bruce M BM
Quertermous T Quertermous Thomas T
Rauramaa R Rauramaa Rainer R
Saleheen D Saleheen Danish D
Salomaa V Salomaa Veikko V
Sanghera DK Sanghera Dharambir K DK
Saramies J Saramies Jouko J
Schwarz PE Schwarz Peter E H PE
Sheu WH Sheu Wayne H-H WH
Shuldiner AR Shuldiner Alan R AR
Siegbahn A Siegbahn Agneta A
Spector TD Spector Tim D TD
Stefansson K Stefansson Kari K
Strachan DP Strachan David P DP
Tayo BO Tayo Bamidele O BO
Tremoli E Tremoli Elena E
Tuomilehto J Tuomilehto Jaakko J
Uusitupa M Uusitupa Matti M
van Duijn CM van Duijn Cornelia M CM
Vollenweider P Vollenweider Peter P
Wallentin L Wallentin Lars L
Wareham NJ Wareham Nicholas J NJ
Whitfield JB Whitfield John B JB
Wolffenbuttel BH Wolffenbuttel Bruce H R BH
Ordovas JM Ordovas Jose M JM
Boerwinkle E Boerwinkle Eric E
Palmer CN Palmer Colin N A CN
Thorsteinsdottir U Thorsteinsdottir Unnur U
Chasman DI Chasman Daniel I DI
Rotter JI Rotter Jerome I JI
Franks PW Franks Paul W PW
Ripatti S Ripatti Samuli S
Cupples LA Cupples L Adrienne LA
Sandhu MS Sandhu Manjinder S MS
Rich SS Rich Stephen S SS
Boehnke M Boehnke Michael M
Deloukas P Deloukas Panos P
Kathiresan S Kathiresan Sekar S
Mohlke KL Mohlke Karen L KL
Ingelsson E Ingelsson Erik E
Abecasis GR Abecasis Gonçalo R GR
INVESTIGATORS
JOURNAL
VOLUME: 45
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2013
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
CZB/4/672 Chief Scientist Office United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
G0801566 Medical Research Council United Kingdom
G0901213 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106179472 Medical Research Council United Kingdom
MC_U106188470 Medical Research Council United Kingdom
MC_U123092720 Medical Research Council United Kingdom
MC_U950080926 Medical Research Council United Kingdom
MR/K013351/1 Medical Research Council United Kingdom
MR/L003120/1 Medical Research Council United Kingdom
P30 DK063491 NIDDK NIH HHS United States
P60 DK020541 NIDDK NIH HHS United States
PG/08/094/26019 British Heart Foundation United Kingdom
R00 HL094535 NHLBI NIH HHS United States
R01 DK072193 NIDDK NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
R01 HL109946 NHLBI NIH HHS United States
RG/08/008/25291 British Heart Foundation United Kingdom
RG/08/014/24067 British Heart Foundation United Kingdom
U01 HL069757 NHLBI NIH HHS United States
UL1 TR000124 NCATS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
African Continental Ancestry Group genetics
Asian Continental Ancestry Group genetics
Cholesterol, HDL genetics
Cholesterol, LDL genetics
Coronary Artery Disease genetics
European Continental Ancestry Group genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Genotype genetics
Humans genetics
Lipids genetics
Triglycerides genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Cholesterol, HDL
0 Cholesterol, LDL
0 Lipids
0 Triglycerides
OTHER ID's
OTHERID SOURCE
NIHMS524703 NLM
PMC3838666 NLM