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| PMID |
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| TITLE |
|
| Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders. |
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| ABSTRACT |
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| Migraine and major depressive disorder (MDD) are comorbid, moderately heritable and to some extent influenced by the same genes. In a previous paper, we suggested the possibility of causality (one trait causing the other) underlying this comorbidity. We present a new application of polygenic (genetic risk) score analysis to investigate the mechanisms underlying the genetic overlap of migraine and MDD. Genetic risk scores were constructed based on data from two discovery samples in which genome-wide association analyses (GWA) were performed for migraine and MDD, respectively. The Australian Twin Migraine GWA study (N = 6,350) included 2,825 migraine cases and 3,525 controls, 805 of whom met the diagnostic criteria for MDD. The RADIANT GWA study (N = 3,230) included 1,636 MDD cases and 1,594 controls. Genetic risk scores for migraine and for MDD were used to predict pure and comorbid forms of migraine and MDD in an independent Dutch target sample (NTR-NESDA, N = 2,966), which included 1,476 MDD cases and 1,058 migraine cases (723 of these individuals had both disorders concurrently). The observed patterns of prediction suggest that the 'pure' forms of migraine and MDD are genetically distinct disorders. The subgroup of individuals with comorbid MDD and migraine were genetically most similar to MDD patients. These results indicate that in at least a subset of migraine patients with MDD, migraine may be a symptom or consequence of MDD. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/07/19 |
| accepted |
2013/09/22 |
| aheadofprint |
2013/10/01 |
| entrez |
2013/10/02 06:00 |
| pubmed |
2013/10/02 06:00 |
| medline |
2014/03/29 06:00 |
| pmc-release |
2015/02/01 00:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ligthart L |
|
Ligthart |
Lannie |
L |
|
Department of Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands, rsl.ligthart@vu.nl. |
| Hottenga JJ |
|
Hottenga |
Jouke-Jan |
JJ |
|
|
| Lewis CM |
|
Lewis |
Cathryn M |
CM |
|
|
| Farmer AE |
|
Farmer |
Anne E |
AE |
|
|
| Craig IW |
|
Craig |
Ian W |
IW |
|
|
| Breen G |
|
Breen |
Gerome |
G |
|
|
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
| Vink JM |
|
Vink |
Jacqueline M |
JM |
|
|
| Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
|
|
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Pergadia ML |
|
Pergadia |
Michele L |
ML |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Penninx BW |
|
Penninx |
Brenda W J H |
BW |
|
|
| McGuffin P |
|
McGuffin |
Peter |
P |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
| Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 133 |
| ISSUE: 2 |
| TITLE: Human genetics |
| ISOABBREVIATION: Hum. Genet. |
| YEAR: 2014 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1432-1203 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Hum Genet |
| COUNTRY: Germany |
| ISSNLINKING: 0340-6717 |
| NLMUNIQUEID: 7613873 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| DA019951 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| G0000647 |
Medical Research Council |
United Kingdom |
| G0701420 |
Medical Research Council |
United Kingdom |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| MH081802 |
NIMH NIH HHS |
United States |
| MH66206 |
NIMH NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| R01 MH066206 |
NIMH NIH HHS |
United States |
| R01 MH081802 |
NIMH NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
epidemiology |
| Comorbidity |
epidemiology |
| Depressive Disorder, Major |
psychology |
| Female |
psychology |
| Genetic Testing |
psychology |
| Genome-Wide Association Study |
psychology |
| Humans |
psychology |
| Interviews as Topic |
psychology |
| Male |
psychology |
| Middle Aged |
psychology |
| Migraine Disorders |
psychology |
| Multifactorial Inheritance |
genetics |
| Netherlands |
epidemiology |
| Polymorphism, Single Nucleotide |
genetics |
| Risk Factors |
genetics |
| Young Adult |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS528798 [Available on 02/01/15] |
NLM |
| PMC3947136 [Available on 02/01/15] |
NLM |
|
|
