Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23948529
TITLE
Causal influence of age at first drink on alcohol involvement in adulthood and its moderation by familial context.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Previous research has established a connection between early age at drinking initiation and greater alcohol involvement in adulthood, but it has not yet been established whether this is a causal effect. The current study used a multilevel discordant twin design to examine individual and contextual effects, and an interaction between these effects, of the age at drinking initiation on the frequency and quantity of drinking in adulthood.
METHOD NlmCategory: METHODS
Participants were 4,194 same-sex twins (2,264 monozygotic, 1,924 dizygotic; 2,270 women; Mage = 29.9 years) from the Australian Twin Registry who completed a telephone interview that included assessments of the age at alcohol use initiation and past-year frequency and quantity of alcohol use. Multilevel models were estimated using data from the full sample and using data from only monozygotic twins. Individual (within-twin-pair comparison) and family contextual (between-twin-pair comparison) effects were estimated.
RESULTS NlmCategory: RESULTS
The age at first drink was related to the past-year frequency (r = -.16) and quantity of drinking (r = -.12) in young adulthood. Individual (causal) and family context effects of age at drinking onset predicted later adult drinking frequency and quantity. There was also a significant cross-level interaction between individual and family contexts for frequency but not quantity of drinking.
CONCLUSIONS NlmCategory: CONCLUSIONS
Results of this study indicate a potential causal effect of age at drinking onset on adult alcohol involvement as well as the importance of examining both individual and contextual effects in discordant twin studies.
DATE PUBLISHED
2013 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/08/17 06:00
pubmed 2013/08/21 06:00
medline 2014/03/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Deutsch AR Deutsch Arielle R AR Department of Psychological Sciences, University of Missouri-Columbia, Columbia, Missouri 65211, USA arielle.deutsch@gmail.com
Slutske WS Slutske Wendy S WS
Richmond-Rakerd LS Richmond-Rakerd Leah S LS
Chernyavskiy P Chernyavskiy Pavel P
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 74
ISSUE: 5
TITLE: Journal of studies on alcohol and drugs
ISOABBREVIATION: J Stud Alcohol Drugs
YEAR: 2013
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-4114
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Stud Alcohol Drugs
COUNTRY: United States
ISSNLINKING: 1937-1888
NLMUNIQUEID: 101295847
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07728 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Age of Onset
Alcohol Drinking epidemiology
Australia epidemiology
Data Collection epidemiology
Family epidemiology
Female epidemiology
Humans epidemiology
Male epidemiology
Twins, Dizygotic epidemiology
Twins, Monozygotic epidemiology
Young Adult epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3749313 NLM
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