Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23948525
TITLE
A twin study of alcohol dependence, binge eating, and compensatory behaviors.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
Rates of alcohol dependence are elevated in women with eating disorders who engage in binge eating or compensatory behaviors compared with women with eating disorders who do not report binge eating or compensatory behaviors and with healthy controls. Alcohol dependence, binge eating, and compensatory behaviors are heritable; however, it is unclear whether a shared genetic liability contributes to the phenotypic association among these traits, and little information exists regarding this shared liability in men. We investigated genetic and environmental correlations among alcohol dependence, binge eating, and compensatory behaviors in male and female twins.
METHOD NlmCategory: METHODS
Participants included 5,993 same- and opposite-sex twins from the Australian Twin Registry who completed a modified version of the Semi-Structured Assessment for the Genetics of Alcoholism that assessed lifetime alcohol dependence and binge eating as defined in the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Compensatory behaviors were assessed via a general health questionnaire in women only. Biometrical twin models estimated genetic and environmental influences on alcohol dependence, binge eating, and compensatory behaviors.
RESULTS NlmCategory: RESULTS
In women, the multivariate twin model suggested that additive genetic and nonshared environmental effects influenced alcohol dependence, binge eating, and compensatory behaviors, with heritability estimates ranging from 38% to 53%. The best-fitting sex-limitation model was a common effects model that equated all genetic and nonshared environmental influences in men and women. The heritability estimates were 50% and 38% for alcohol dependence and binge eating, respectively. Overall, there were significant genetic correlations between alcohol dependence and binge eating, alcohol dependence and compensatory behaviors, and binge eating and compensatory behaviors.
CONCLUSIONS NlmCategory: CONCLUSIONS
These findings indicate that common genetic factors may underlie the vulnerability to alcohol dependence and the liability to binge eating and compensatory behaviors.
DATE PUBLISHED
2013 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/08/17 06:00
pubmed 2013/08/21 06:00
medline 2014/03/14 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Munn-Chernoff MA Munn-Chernoff Melissa A MA Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA. munnme@psychiatry.wustl.edu
Duncan AE Duncan Alexis E AE
Grant JD Grant Julia D JD
Wade TD Wade Tracey D TD
Agrawal A Agrawal Arpana A
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
Heath AC Heath Andrew C AC
INVESTIGATORS
JOURNAL
VOLUME: 74
ISSUE: 5
TITLE: Journal of studies on alcohol and drugs
ISOABBREVIATION: J Stud Alcohol Drugs
YEAR: 2013
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1938-4114
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Stud Alcohol Drugs
COUNTRY: United States
ISSNLINKING: 1937-1888
NLMUNIQUEID: 101295847
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
T32 AA007580 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Alcoholism genetics
Australia genetics
Bulimia genetics
Eating Disorders genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Middle Aged genetics
Multivariate Analysis genetics
Questionnaires genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3749309 NLM
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