Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23931641
TITLE
Heritability of resting state EEG functional connectivity patterns.
ABSTRACT
We examined the genetic architecture of functional brain connectivity measures in resting state electroencephalographic (EEG) recordings. Previous studies in Dutch twins have suggested that genetic factors are a main source of variance in functional brain connectivity derived from EEG recordings. In addition, qualitative descriptors of the brain network derived from graph analysis - network clustering and average path length - are also heritable traits. Here we replicated previous findings for connectivity, quantified by the synchronization likelihood, and the graph theoretical parameters cluster coefficient and path length in an Australian sample of 16-year-old twins (879) and their siblings (93). Modeling of monozygotic and dizygotic twins and sibling resemblance indicated heritability estimates of the synchronization likelihood (27-74%) and cluster coefficient and path length in the alpha and theta band (40-44% and 23-40% respectively) and path length in the beta band frequency (41%). This corroborates synchronization likelihood and its graph theoretical derivatives cluster coefficient and path length as potential endophenotypes for behavioral traits and neurological disorders.
DATE PUBLISHED
2013 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2013/08/09
entrez 2013/08/13 06:00
pubmed 2013/08/13 06:00
medline 2013/08/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Schutte NM Schutte Nienke M NM Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands.
Hansell NK Hansell Narelle K NK
de Geus EJ de Geus Eco J C EJ
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Smit DJ Smit Dirk J A DJ
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 5
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2013
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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