Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23889901
TITLE
Genetic and environmental influences on the ages of drinking and gambling initiation: evidence for distinct aetiologies and sex differences.
ABSTRACT
AIMS NlmCategory: OBJECTIVE
To investigate the genetic and environmental contributions to age at first drink (AFD) and age first gambled (AFG), assess their overlap and examine sex differences.
DESIGN NlmCategory: METHODS
Univariate twin models were fitted to decompose the variation in AFD and AFG into additive genetic, shared environmental and unique environmental factors. Bivariate genetic models were fitted to assess the genetic and environmental contributions to the sources of covariation in AFD and AFG.
SETTING NlmCategory: METHODS
National Australian Twin Registry.
PARTICIPANTS NlmCategory: METHODS
A total of 4542 same-sex and opposite-sex twins aged 32-43 years, 42% male and 58% female.
MEASUREMENTS NlmCategory: METHODS
AFD and AFG were assessed via structured psychiatric telephone interviews. Age of onset was treated as both continuous and categorical (early/late onset).
FINDINGS NlmCategory: RESULTS
AFD and AFG were modestly correlated (r = 0.18). Unique environmental influences explained a substantial proportion of the variation in both AFD (0.55, 95% confidence interval [CI] = 0.50-0.61) and AFG (0.66, 95% CI = 0.59-0.72), but these influences were uncorrelated (rE  = 0.01). Additive genetic factors explained a notable proportion of variation in AFG (0.21, 95% CI = 0.003-0.39), while shared environmental factors were important for AFD (0.31, 95% CI = 0.15-0.46). Among men, genetic factors influenced variation in AFG but not in AFD and shared environmental factors influenced variation in AFD but not in AFG. Among women, shared environmental factors influenced variation in both AFD and AFG, but these environmental factors were not significantly correlated (rC  = 0.09).
CONCLUSIONS NlmCategory: CONCLUSIONS
Among Australian twins, age at first drink and age first gambled are influenced by distinct unique environmental factors, and the genetic and environmental underpinnings of both phenotypes differ in men and women.
2013 Society for the Study of Addiction.
DATE PUBLISHED
2014 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/02/22
revised 2013/05/02
accepted 2013/07/18
aheadofprint 2013/08/28
entrez 2013/07/30 06:00
pubmed 2013/07/31 06:00
medline 2015/04/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS Department of Psychological Sciences, University of Missouri, Columbia, MO, USA; Midwest Alcoholism Research Center, Columbia, MO and St. Louis, MO, USA.
Slutske WS Slutske Wendy S WS
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 109
ISSUE: 2
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2014
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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CommentIn Addiction. 2014 Feb;109(2):332 24422620
GRANTS
GRANTID AGENCY COUNTRY
AA007728 NIAAA NIH HHS United States
AA13526 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Age of onset
alcohol use
gambling
sex differences
twins
unique environment
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Alcohol Drinking genetics
Australia epidemiology
Environment epidemiology
Female epidemiology
Gambling genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Models, Genetic genetics
Phenotype genetics
Sex Factors genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS513890 NLM
PMC3947163 NLM