Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23875064
TITLE
Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.
ABSTRACT
The CHRNA5-CHRNA3-CHRNB4 gene cluster on chromosome 15q25.1 encoding the cholinergic nicotinic receptor subunits is robustly associated with smoking behavior and nicotine dependence. Only a few studies to date have examined the locus with alcohol related traits and found evidence of association with alcohol abuse and dependence. Our main goal was to examine the role of three intensively studied single nucleotide polymorphisms, rs16969968, rs578776 and rs588765, tagging three distinct loci, in alcohol use. Our sample was drawn from two independent Finnish population-based surveys, the National FINRISK Study and the Health 2000 (Health Examination) Survey. The combined sample included a total of 32,592 adult Finns (54% women) of whom 8,356 were assessed for cigarettes per day (CPD). Data on alcohol use were available for 31,812 individuals. We detected a novel association between rs588765 and alcohol use defined as abstainers and low-frequency drinkers versus drinkers (OR=1.15, p=0.00007). Additionally, we provide precise estimates of strength of the association between the three loci and smoking quantity in a very large population based sample. As a conclusion, our results provide further evidence for the nicotine-specific role of rs16969968 (locus 1). Further, our data suggest that the effect of rs588765 (locus 3) may be specific to alcohol use as the effect is seen also in never smokers.
DATE PUBLISHED
2013
HISTORY
PUBSTATUS PUBSTATUSDATE
ppublish 2013
received 2013/06/20
accepted 2013/06/20
epublish 2013/06/25
entrez 2013/07/23 06:00
pubmed 2013/07/23 06:00
medline 2013/07/23 06:01
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hällfors J Hällfors Jenni J Institute for Molecular Medicine Finland FIMM, University of Helsinki Helsinki, Finland ; Department of Public Health, Hjelt Institute, University of Helsinki Helsinki, Finland.
Loukola A Loukola Anu A
Pitkäniemi J Pitkäniemi Janne J
Broms U Broms Ulla U
Männistö S Männistö Satu S
Salomaa V Salomaa Veikko V
Heliövaara M Heliövaara Markku M
Lehtimäki T Lehtimäki Terho T
Raitakari O Raitakari Olli O
Madden PA Madden Pamela Af PA
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Korhonen T Korhonen Tellervo T
Kaprio J Kaprio Jaakko J
INVESTIGATORS
JOURNAL
VOLUME: 4
ISSUE: 2
TITLE: International journal of molecular epidemiology and genetics
ISOABBREVIATION: Int J Mol Epidemiol Genet
YEAR: 2013
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1948-1756
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Mol Epidemiol Genet
COUNTRY: United States
ISSNLINKING: 1948-1756
NLMUNIQUEID: 101525762
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
K05 AA017688 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
15q25.1
Nicotinic acetylcholine receptors
alcohol use
genetic association
population-based sample
public health
smoking behavior
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3709115 NLM