Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23793025
TITLE
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
ABSTRACT
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
DATE PUBLISHED
2013 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/11/07
accepted 2013/05/30
entrez 2013/06/25 06:00
pubmed 2013/06/26 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anttila V Anttila Verneri V Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Winsvold BS Winsvold Bendik S BS Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Gormley P Gormley Padhraig P Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Kurth T Kurth Tobias T Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Bettella F Bettella Francesco F deCODE genetics, Reykjavik, Iceland.
McMahon G McMahon George G MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Kallela M Kallela Mikko M Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Malik R Malik Rainer R Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
de Vries B de Vries Boukje B Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Terwindt G Terwindt Gisela G Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Medland SE Medland Sarah E SE Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Todt U Todt Unda U Institute of Human Genetics, University of Ulm, Ulm, Germany.
McArdle WL McArdle Wendy L WL MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Quaye L Quaye Lydia L Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Koiranen M Koiranen Markku M Institute of Health Sciences, University of Oulu, Oulu, Finland.
Ikram MA Ikram M Arfan MA Department of Neurology Erasmus University Medical Centre, Rotterdam, The Netherlands.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Stam AH Stam Anine H AH Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Ligthart L Ligthart Lannie L EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Wedenoja J Wedenoja Juho J Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Dunham I Dunham Ian I European Bioinformatics Insitute, Wellcome Trust Genome Campus, Cambridge, UK.
Neale BM Neale Benjamin M BM Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Palta P Palta Priit P Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Hamalainen E Hamalainen Eija E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Schürks M Schürks Markus M Department of Neurology, University Hospital Essen, Essen, Germany.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Buring JE Buring Julie E JE Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA 02215, USA.
Steinberg S Steinberg Stacy S deCODE genetics, Reykjavik, Iceland.
Stefansson H Stefansson Hreinn H deCODE genetics, Reykjavik, Iceland.
Jakobsson F Jakobsson Finnbogi F Department of Neurology, Landspitali University Hospital, Reykjavik, Iceland.
Lawlor DA Lawlor Debbie A DA MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Evans DM Evans David M DM MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Ring SM Ring Susan M SM MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Färkkilä M Färkkilä Markus M Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Artto V Artto Ville V Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Kaunisto MA Kaunisto Mari A MA Folkhälsan Research Center, Helsinki, Finland.
Freilinger T Freilinger Tobias T Department of Neurology, Klinikum der Universität München, Munich, Germany.
Schoenen J Schoenen Jean J Headache Research Unit, Department of Neurology and Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA)-Neurosciences, Liège University, Liège, Belgium.
Frants RR Frants Rune R RR Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Pelzer N Pelzer Nadine N Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Weller CM Weller Claudia M CM Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Zielman R Zielman Ronald R Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Madden PAF Madden Pamela A F PAF Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Montgomery GW Montgomery Grant W GW Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Borck G Borck Guntram G Institute of Human Genetics, University of Ulm, Ulm, Germany.
Göbel H Göbel Hartmut H Kiel Pain and Headache Center, Kiel, Germany.
Heinze A Heinze Axel A Kiel Pain and Headache Center, Kiel, Germany.
Heinze-Kuhn K Heinze-Kuhn Katja K Kiel Pain and Headache Center, Kiel, Germany.
Williams FMK Williams Frances M K FMK Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Hartikainen AL Hartikainen Anna-Liisa AL Department of Clinical Sciences/Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland.
Pouta A Pouta Anneli A Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland.
van den Ende J van den Ende Joyce J Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Uitterlinden AG Uitterlinden Andre G AG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Hofman A Hofman Albert A Genetic Epidemiology Unit, Department of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Amin N Amin Najaf N Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Vink JM Vink Jacqueline M JM Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Heikkilä K Heikkilä Kauko K Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Alexander M Alexander Michael M Institute of Human Genetics, University of Bonn, Bonn, Germany.
Muller-Myhsok B Muller-Myhsok Bertram B Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Schreiber S Schreiber Stefan S Department of Internal Medicine I, Christian Albrechts University, Kiel, Germany.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Wichmann HE Wichmann Heinz Erich HE Klinikum Großhadern, Ludwig-Maximilians-Universität München, Munich, Germany.
Aromaa A Aromaa Arpo A National Institute for Health and Welfare, Helsinki, Finland.
Eriksson JG Eriksson Johan G JG Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Traynor B Traynor Bryan B Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Trabzuni D Trabzuni Daniah D Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
North American Brain Expression Consortium
UK Brain Expression Consortium
Rossin E Rossin Elizabeth E Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
Lage K Lage Kasper K Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Jacobs SBR Jacobs Suzanne B R SBR Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gibbs JR Gibbs J Raphael JR Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Birney E Birney Ewan E European Bioinformatics Insitute, Wellcome Trust Genome Campus, Cambridge, UK.
Kaprio J Kaprio Jaakko J Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
Penninx BW Penninx Brenda W BW Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
van Duijn C van Duijn Cornelia C Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Raitakari O Raitakari Olli O Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Jarvelin MR Jarvelin Marjo-Riitta MR Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland.
Zwart JA Zwart John-Anker JA Department of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Cherkas L Cherkas Lynn L Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Strachan DP Strachan David P DP Division of Population Health Sciences and Education, St George's, University of London, London, UK.
Kubisch C Kubisch Christian C Institute of Human Genetics, University of Ulm, Ulm, Germany.
Ferrari MD Ferrari Michel D MD Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
van den Maagdenberg AMJM van den Maagdenberg Arn M J M AMJM Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Dichgans M Dichgans Martin M Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Wessman M Wessman Maija M Folkhälsan Research Center, Helsinki, Finland.
Smith GD Smith George Davey GD MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Stefansson K Stefansson Kari K School of Medicine, University of Iceland, Reykjavik, Iceland.
Daly MJ Daly Mark J MJ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nyholt DR Nyholt Dale R DR Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Chasman D Chasman Daniel D Harvard Medical School, Boston, MA 02215, USA.
Palotie A Palotie Aarno A Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Arepalli Sampath S
Cookson Mark R MR
Dillman Allissa A
Ferrucci Luigi L
Gibbs J Raphael JR
Hernandez Dena G DG
Johnson Robert R
Longo Dan L DL
Nalls Michael A MA
O'Brien Richard R
Singleton Andrew A
Traynor Bryan B
Troncoso Juan J
van der Brug Marcel M
Zielke H R HR
Zonderman Alan B AB
Hardy John A JA
Ryten Mina M
Smith Colin C
Trabzuni Daniah D
Walker Robert R
Weale Mike E ME
Anttila Verneri V
Winsvold Bendik S BS
Gormley Padhraig P
Kurth Tobias T
Bettella Francesco F
McMahon George G
Kallela Mikko M
Malik Rainer R
de Vries Boukje B
Terwindt Gisela G
Todt Unda U
Quaye Lydia L
Palta Priit P
Hämäläinen Eija E
Schürks Markus M
Steinberg Stacy S
Stefansson Hreinn H
Färkkilä Markus M
Artto Ville V
Kaunisto Mari A MA
Freilinger Tobias T
Schoenen Jean J
Frants Rune R RR
Borck Guntram G
Göbel Hartmut H
Heinze Axel A
Heinze-Kuhn Katja K
Muller-Myhsok Bertram B
Kaprio Jaakko J
Zwart John-Anker JA
Cherkas Lynn L
Strachan David P DP
Kubisch Christian C
Ferrari Michel D MD
van den Maagdenberg Arn M J M AM
Dichgans Martin M
Wessman Maija M
Smith George Davey GD
Nyholt Dale R DR
Chasman Daniel D
Palotie Aarno A
JOURNAL
VOLUME: 45
ISSUE: 8
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2013
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Nat Rev Neurol. 2013 Aug;9(8):419 23835538
GRANTS
GRANTID AGENCY COUNTRY
G1001799 Medical Research Council United Kingdom
G0802462 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
092731 Wellcome Trust United Kingdom
T32 GM007753 NIGMS NIH HHS United States
MC_UU_12013/1 Medical Research Council United Kingdom
MC_UU_12013/4 Medical Research Council United Kingdom
089062 Wellcome Trust United Kingdom
Z01 AG000949-02 Intramural NIH HHS United States
MC_UU_12013/5 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Cerebellum metabolism
Computational Biology metabolism
Frontal Lobe metabolism
Genetic Loci metabolism
Genetic Predisposition to Disease metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Migraine Disorders genetics
Polymorphism, Single Nucleotide genetics
Quantitative Trait Loci genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
EMS53496 NLM
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