Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23793025
TITLE
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
ABSTRACT
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
DATE PUBLISHED
2013 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/11/07
accepted 2013/05/30
aheadofprint 2013/06/23
entrez 2013/06/25 06:00
pubmed 2013/06/26 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anttila V Anttila Verneri V Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. anttila@atgu.mgh.harvard.edu
Winsvold BS Winsvold Bendik S BS
Gormley P Gormley Padhraig P
Kurth T Kurth Tobias T
Bettella F Bettella Francesco F
McMahon G McMahon George G
Kallela M Kallela Mikko M
Malik R Malik Rainer R
de Vries B de Vries Boukje B
Terwindt G Terwindt Gisela G
Medland SE Medland Sarah E SE
Todt U Todt Unda U
McArdle WL McArdle Wendy L WL
Quaye L Quaye Lydia L
Koiranen M Koiranen Markku M
Ikram MA Ikram M Arfan MA
Lehtimäki T Lehtimäki Terho T
Stam AH Stam Anine H AH
Ligthart L Ligthart Lannie L
Wedenoja J Wedenoja Juho J
Dunham I Dunham Ian I
Neale BM Neale Benjamin M BM
Palta P Palta Priit P
Hamalainen E Hamalainen Eija E
Schürks M Schürks Markus M
Rose LM Rose Lynda M LM
Buring JE Buring Julie E JE
Ridker PM Ridker Paul M PM
Steinberg S Steinberg Stacy S
Stefansson H Stefansson Hreinn H
Jakobsson F Jakobsson Finnbogi F
Lawlor DA Lawlor Debbie A DA
Evans DM Evans David M DM
Ring SM Ring Susan M SM
Färkkilä M Färkkilä Markus M
Artto V Artto Ville V
Kaunisto MA Kaunisto Mari A MA
Freilinger T Freilinger Tobias T
Schoenen J Schoenen Jean J
Frants RR Frants Rune R RR
Pelzer N Pelzer Nadine N
Weller CM Weller Claudia M CM
Zielman R Zielman Ronald R
Heath AC Heath Andrew C AC
Madden PA Madden Pamela A F PA
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Borck G Borck Guntram G
Göbel H Göbel Hartmut H
Heinze A Heinze Axel A
Heinze-Kuhn K Heinze-Kuhn Katja K
Williams FM Williams Frances M K FM
Hartikainen AL Hartikainen Anna-Liisa AL
Pouta A Pouta Anneli A
van den Ende J van den Ende Joyce J
Uitterlinden AG Uitterlinden Andre G AG
Hofman A Hofman Albert A
Amin N Amin Najaf N
Hottenga JJ Hottenga Jouke-Jan JJ
Vink JM Vink Jacqueline M JM
Heikkilä K Heikkilä Kauko K
Alexander M Alexander Michael M
Muller-Myhsok B Muller-Myhsok Bertram B
Schreiber S Schreiber Stefan S
Meitinger T Meitinger Thomas T
Wichmann HE Wichmann Heinz Erich HE
Aromaa A Aromaa Arpo A
Eriksson JG Eriksson Johan G JG
Traynor BJ Traynor Bryan J BJ
Trabzuni D Trabzuni Daniah D
Rossin E Rossin Elizabeth E
Lage K Lage Kasper K
Jacobs SB Jacobs Suzanne B R SB
Gibbs JR Gibbs J Raphael JR
Birney E Birney Ewan E
Kaprio J Kaprio Jaakko J
Penninx BW Penninx Brenda W BW
Boomsma DI Boomsma Dorret I DI
van Duijn C van Duijn Cornelia C
Raitakari O Raitakari Olli O
Jarvelin MR Jarvelin Marjo-Riitta MR
Zwart JA Zwart John-Anker JA
Cherkas L Cherkas Lynn L
Strachan DP Strachan David P DP
Kubisch C Kubisch Christian C
Ferrari MD Ferrari Michel D MD
van den Maagdenberg AM van den Maagdenberg Arn M J M AM
Dichgans M Dichgans Martin M
Wessman M Wessman Maija M
Smith GD Smith George Davey GD
Stefansson K Stefansson Kari K
Daly MJ Daly Mark J MJ
Nyholt DR Nyholt Dale R DR
Chasman DI Chasman Daniel I DI
Palotie A Palotie Aarno A
North American Brain Expression Consortium
UK Brain Expression Consortium
International Headache Genetics Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Arepalli Sampath S
Cookson Mark R MR
Dillman Allissa A
Ferrucci Luigi L
Gibbs J Raphael JR
Hernandez Dena G DG
Johnson Robert R
Longo Dan L DL
Nalls Michael A MA
O'Brien Richard R
Singleton Andrew A
Traynor Bryan B
Troncoso Juan J
van der Brug Marcel M
Zielke H R HR
Zonderman Alan B AB
Hardy John A JA
Ryten Mina M
Smith Colin C
Trabzuni Daniah D
Walker Robert R
Weale Mike E ME
Anttila Verneri V
Winsvold Bendik S BS
Gormley Padhraig P
Kurth Tobias T
Bettella Francesco F
McMahon George G
Kallela Mikko M
Malik Rainer R
de Vries Boukje B
Terwindt Gisela G
Todt Unda U
Quaye Lydia L
Palta Priit P
Hämäläinen Eija E
Schürks Markus M
Steinberg Stacy S
Stefansson Hreinn H
Färkkilä Markus M
Artto Ville V
Kaunisto Mari A MA
Freilinger Tobias T
Schoenen Jean J
Frants Rune R RR
Borck Guntram G
Göbel Hartmut H
Heinze Axel A
Heinze-Kuhn Katja K
Muller-Myhsok Bertram B
Kaprio Jaakko J
Zwart John-Anker JA
Cherkas Lynn L
Strachan David P DP
Kubisch Christian C
Ferrari Michel D MD
van den Maagdenberg Arn M J M AM
Dichgans Martin M
Wessman Maija M
Smith George Davey GD
Nyholt Dale R DR
Chasman Daniel D
Palotie Aarno A
JOURNAL
VOLUME: 45
ISSUE: 8
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2013
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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CommentIn Nat Rev Neurol. 2013 Aug;9(8):419 23835538
GRANTS
GRANTID AGENCY COUNTRY
089062 Wellcome Trust United Kingdom
092731 Wellcome Trust United Kingdom
G0802462 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MC_PC_15018 Medical Research Council United Kingdom
MC_UU_12013/1 Medical Research Council United Kingdom
T32 GM007753 NIGMS NIH HHS United States
Z01 AG000949-02 Intramural NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Cerebellum metabolism
Computational Biology metabolism
Frontal Lobe metabolism
Genetic Loci metabolism
Genetic Predisposition to Disease metabolism
Genome-Wide Association Study metabolism
Humans metabolism
Migraine Disorders genetics
Polymorphism, Single Nucleotide genetics
Quantitative Trait Loci genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
EMS53496 NLM
PMC4041123 NLM