Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23636971
TITLE
Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury.
ABSTRACT
Traumatic brain injury often results in acute metabolic crisis. We recently demonstrated that this is associated with chronic brain atrophy, which is most prominent in the frontal and temporal lobes. Interestingly, the neuropsychological profile of traumatic brain injury is often characterized as 'frontal-temporal' in nature, suggesting a possible link between acute metabolic crisis-related brain atrophy and neurocognitive impairment in this population. While focal lesions and diffuse axonal injury have a well-established role in the neuropsychological deficits observed following traumatic brain injury, no studies to date have examined the possible contribution of acute metabolic crisis-related atrophy in the neuropsychological sequelae of traumatic brain injury. In the current study we employed positron emission tomography, magnetic resonance imaging, and neuropsychological assessments to ascertain the relationship between acute metabolic crisis-related brain atrophy and neurocognitive outcome in a sample of 14 right-handed traumatic brain injury survivors. We found that acute metabolic crisis-related atrophy in the frontal and temporal lobes was associated with poorer attention, executive functioning, and psychomotor abilities at 12 months post-injury. Furthermore, participants with gross frontal and/or temporal lobe atrophy exhibited numerous clinically significant neuropsychological deficits in contrast to participants with other patterns of brain atrophy. Our findings suggest that interventions that reduce acute metabolic crisis may lead to improved functional outcomes for traumatic brain injury survivors.
DATE PUBLISHED
2013 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/05/03 06:00
pubmed 2013/05/03 06:00
medline 2014/07/02 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wright MJ Wright Matthew J MJ Los Angeles Biomedical Research Institute, Psychology Division, Department of Psychiatry, Harbor-University of California, Los Angeles Medical Center, 1124 W. Carson St., B-4 South (Box 490), Torrance, CA, 90502, USA, mwright@labiomed.org.
McArthur DL McArthur David L DL
Alger JR Alger Jeffry R JR
Van Horn J Van Horn Jack J
Irimia A Irimia Andrei A
Filippou M Filippou Maria M
Glenn TC Glenn Thomas C TC
Hovda DA Hovda David A DA
Vespa P Vespa Paul P
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 3
TITLE: Brain imaging and behavior
ISOABBREVIATION: Brain Imaging Behav
YEAR: 2013
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1931-7565
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Brain Imaging Behav
COUNTRY: United States
ISSNLINKING: 1931-7557
NLMUNIQUEID: 101300405
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
K08 NS002089 NINDS NIH HHS United States
NS02089 NINDS NIH HHS United States
NS049471 NINDS NIH HHS United States
P01 NS058489 NINDS NIH HHS United States
P01-NS058489 NINDS NIH HHS United States
P41 EB015922 NIBIB NIH HHS United States
R01 NS049471 NINDS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Atrophy physiopathology
Brain physiopathology
Brain Diseases, Metabolic physiopathology
Brain Injuries physiopathology
Cognition physiopathology
Cognition Disorders physiopathology
Female physiopathology
Humans physiopathology
Male physiopathology
Survivors physiopathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS474955 NLM
PMC4172457 NLM
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