Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23629049
TITLE
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group.
ABSTRACT
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic variants that influence the brain. Diffusion tensor imaging (DTI) yields quantitative measures sensitive to brain development and degeneration, and some common genetic variants may be associated with white matter integrity or connectivity. DTI measures, such as the fractional anisotropy (FA) of water diffusion, may be useful for identifying genetic variants that influence brain microstructure. However, genome-wide association studies (GWAS) require large populations to obtain sufficient power to detect and replicate significant effects, motivating a multi-site consortium effort. As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data collected at multiple sites. Four hundred images of healthy adults aged 18-85 from four sites were used to create a template and corresponding skeletonized FA image as a common reference space. Using twin and pedigree samples of different ethnicities, we used our common template to evaluate the heritability of tract-derived FA measures. We show that our template is reliable for integrating multiple datasets by combining results through meta-analysis and unifying the data through exploratory mega-analyses. Our results may help prioritize regions of the FA map that are consistently influenced by additive genetic factors for future genetic discovery studies. Protocols and templates are publicly available at (http://enigma.loni.ucla.edu/ongoing/dti-working-group/).
Copyright 2013 The Authors. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2013 Nov 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/01/19
revised 2013/03/28
accepted 2013/04/10
aheadofprint 2013/04/28
entrez 2013/05/01 06:00
pubmed 2013/05/01 06:00
medline 2014/03/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA 90095-7332, USA.
Kochunov PV Kochunov Peter V PV
Sprooten E Sprooten Emma E
Mandl RC Mandl René C RC
Nichols TE Nichols Thomas E TE
Almasy L Almasy Laura L
Blangero J Blangero John J
Brouwer RM Brouwer Rachel M RM
Curran JE Curran Joanne E JE
de Zubicaray GI de Zubicaray Greig I GI
Duggirala R Duggirala Ravi R
Fox PT Fox Peter T PT
Hong LE Hong L Elliot LE
Landman BA Landman Bennett A BA
Martin NG Martin Nicholas G NG
McMahon KL McMahon Katie L KL
Medland SE Medland Sarah E SE
Mitchell BD Mitchell Braxton D BD
Olvera RL Olvera Rene L RL
Peterson CP Peterson Charles P CP
Starr JM Starr John M JM
Sussmann JE Sussmann Jessika E JE
Toga AW Toga Arthur W AW
Wardlaw JM Wardlaw Joanna M JM
Wright MJ Wright Margaret J MJ
Hulshoff Pol HE Hulshoff Pol Hilleke E HE
Bastin ME Bastin Mark E ME
McIntosh AM McIntosh Andrew M AM
Deary IJ Deary Ian J IJ
Thompson PM Thompson Paul M PM
Glahn DC Glahn David C DC
INVESTIGATORS
JOURNAL
VOLUME: 81
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2013
MONTH: Nov
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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ErratumIn Neuroimage. 2014 Apr 15;90:470-1 22111801
GRANTS
GRANTID AGENCY COUNTRY
087727/Z/08/Z Wellcome Trust United Kingdom
486682 Medical Research Council United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
G1001245 Medical Research Council United Kingdom
MH0708143 NIMH NIH HHS United States
MH078111 NIMH NIH HHS United States
MH083824 NIMH NIH HHS United States
MH59490 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
P41 EB015922 NIBIB NIH HHS United States
R01 EB007813 NIBIB NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
R01 EB015611-01 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 MH059490 NIMH NIH HHS United States
R01 MH078111 NIMH NIH HHS United States
U54 MH091657 NIMH NIH HHS United States
U54MH091657-03 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Diffusion Tensor Imaging (DTI)
Heritability
Imaging genetics
Meta-analysis
Multi-site
Reliability
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Anisotropy
Brain
Brain Mapping
Diffusion Tensor Imaging
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Pilot Projects
Registries
Young Adult
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS481850 NLM
PMC3729717 NLM