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| PMID |
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| TITLE |
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| Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. |
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| ABSTRACT |
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| The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic variants that influence the brain. Diffusion tensor imaging (DTI) yields quantitative measures sensitive to brain development and degeneration, and some common genetic variants may be associated with white matter integrity or connectivity. DTI measures, such as the fractional anisotropy (FA) of water diffusion, may be useful for identifying genetic variants that influence brain microstructure. However, genome-wide association studies (GWAS) require large populations to obtain sufficient power to detect and replicate significant effects, motivating a multi-site consortium effort. As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data collected at multiple sites. Four hundred images of healthy adults aged 18-85 from four sites were used to create a template and corresponding skeletonized FA image as a common reference space. Using twin and pedigree samples of different ethnicities, we used our common template to evaluate the heritability of tract-derived FA measures. We show that our template is reliable for integrating multiple datasets by combining results through meta-analysis and unifying the data through exploratory mega-analyses. Our results may help prioritize regions of the FA map that are consistently influenced by additive genetic factors for future genetic discovery studies. Protocols and templates are publicly available at (http://enigma.loni.ucla.edu/ongoing/dti-working-group/). |
| Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/01/19 |
| revised |
2013/03/28 |
| accepted |
2013/04/10 |
| entrez |
2013/05/01 06:00 |
| pubmed |
2013/05/01 06:00 |
| medline |
2014/03/19 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA. |
| Kochunov PV |
|
Kochunov |
Peter V |
PV |
|
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Sprooten E |
|
Sprooten |
Emma |
E |
|
Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Mandl RC |
|
Mandl |
René C |
RC |
|
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Nichols TE |
|
Nichols |
Thomas E |
TE |
|
Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK. |
| Almasy L |
|
Almasy |
Laura |
L |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Blangero J |
|
Blangero |
John |
J |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Brouwer RM |
|
Brouwer |
Rachel M |
RM |
|
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Curran JE |
|
Curran |
Joanne E |
JE |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
University of Queensland, School of Psychology, Brisbane, Australia. |
| Duggirala R |
|
Duggirala |
Ravi |
R |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Fox PT |
|
Fox |
Peter T |
PT |
|
Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA; South Texas Veterans Administration Medical Center, San Antonio, TX, USA. |
| Hong LE |
|
Hong |
L Elliot |
LE |
|
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Landman BA |
|
Landman |
Bennett A |
BA |
|
Vanderbilt University, Electrical Engineering, Nashville, TN, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute of Medical Research, Brisbane, Australia. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
University of Queensland, Center for Advanced Imaging, Brisbane, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Queensland Institute of Medical Research, Brisbane, Australia. |
| Mitchell BD |
|
Mitchell |
Braxton D |
BD |
|
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Olvera RL |
|
Olvera |
Rene L |
RL |
|
Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
| Peterson CP |
|
Peterson |
Charles P |
CP |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Starr JM |
|
Starr |
John M |
JM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
| Sussmann JE |
|
Sussmann |
Jessika E |
JE |
|
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Toga AW |
|
Toga |
Arthur W |
AW |
|
Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA. |
| Wardlaw JM |
|
Wardlaw |
Joanna M |
JM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Queensland Institute of Medical Research, Brisbane, Australia. |
| Hulshoff Pol HE |
|
Hulshoff Pol |
Hilleke E |
HE |
|
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Bastin ME |
|
Bastin |
Mark E |
ME |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. |
| McIntosh AM |
|
McIntosh |
Andrew M |
AM |
|
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA. Electronic address: thompson@loni.ucla.edu. |
| Glahn DC |
|
Glahn |
David C |
DC |
|
Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA. |
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 81 |
| ISSUE: |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2013 |
| MONTH: Nov |
| DAY: 01 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| ErratumIn |
Neuroimage. 2014 Apr 15;90:470-1 |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P41 EB015922 |
NIBIB NIH HHS |
United States |
| R01 EB007813 |
NIBIB NIH HHS |
United States |
| R01 EB015611-01 |
NIBIB NIH HHS |
United States |
| U54 MH091657 |
NIMH NIH HHS |
United States |
| MH59490 |
NIMH NIH HHS |
United States |
| R01 MH059490 |
NIMH NIH HHS |
United States |
| 486682 |
Medical Research Council |
United Kingdom |
| R37 MH059490 |
NIMH NIH HHS |
United States |
| R01 EB008281 |
NIBIB NIH HHS |
United States |
| MH078111 |
NIMH NIH HHS |
United States |
| MH0708143 |
NIMH NIH HHS |
United States |
| 087727/Z/08/Z |
Wellcome Trust |
United Kingdom |
| R01 EB015611 |
NIBIB NIH HHS |
United States |
| MH083824 |
NIMH NIH HHS |
United States |
| G1001245 |
Medical Research Council |
United Kingdom |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| R01 MH078111 |
NIMH NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01 EB008432 |
NIBIB NIH HHS |
United States |
| U54MH091657-03 |
NIMH NIH HHS |
United States |
| G0700704 |
Medical Research Council |
United Kingdom |
|
Wellcome Trust |
United Kingdom |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| R01 MH083824 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
|
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| KEYWORDS |
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| KEYWORD |
| Diffusion Tensor Imaging (DTI) |
| Heritability |
| Imaging genetics |
| Meta-analysis |
| Multi-site |
| Reliability |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
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| Adult |
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| Aged |
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| Aged, 80 and over |
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| Anisotropy |
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| Brain |
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| Brain Mapping |
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| Diffusion Tensor Imaging |
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| Female |
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| Humans |
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| Image Processing, Computer-Assisted |
|
| Male |
|
| Middle Aged |
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| Pilot Projects |
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| Registries |
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| Young Adult |
|
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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