Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23593038
TITLE
The genetic correlation between height and IQ: shared genes or assortative mating?
ABSTRACT
Traits that are attractive to the opposite sex are often positively correlated when scaled such that scores increase with attractiveness, and this correlation typically has a genetic component. Such traits can be genetically correlated due to genes that affect both traits ("pleiotropy") and/or because assortative mating causes statistical correlations to develop between selected alleles across the traits ("gametic phase disequilibrium"). In this study, we modeled the covariation between monozygotic and dizygotic twins, their siblings, and their parents (total N = 7,905) to elucidate the nature of the correlation between two potentially sexually selected traits in humans: height and IQ. Unlike previous designs used to investigate the nature of the height-IQ correlation, the present design accounts for the effects of assortative mating and provides much less biased estimates of additive genetic, non-additive genetic, and shared environmental influences. Both traits were highly heritable, although there was greater evidence for non-additive genetic effects in males. After accounting for assortative mating, the correlation between height and IQ was found to be almost entirely genetic in nature. Model fits indicate that both pleiotropy and assortative mating contribute significantly and about equally to this genetic correlation.
DATE PUBLISHED
2013 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
ppublish 2013/04
received 2012/12/27
accepted 2013/03/01
epublish 2013/04/04
entrez 2013/04/18 06:00
pubmed 2013/04/18 06:00
medline 2013/06/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Keller MC Keller Matthew C MC Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States of America. matthew.c.keller@gmail.com
Garver-Apgar CE Garver-Apgar Christine E CE
Wright MJ Wright Margaret J MJ
Martin NG Martin Nicholas G NG
Corley RP Corley Robin P RP
Stallings MC Stallings Michael C MC
Hewitt JK Hewitt John K JK
Zietsch BP Zietsch Brendan P BP
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 4
TITLE: PLoS genetics
ISOABBREVIATION: PLoS Genet.
YEAR: 2013
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1553-7404
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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ErratumIn PLoS Genet. 2014;10(3):e1004329 6585126
GRANTS
GRANTID AGENCY COUNTRY
DA011015 NIDA NIH HHS United States
DA05131 NIDA NIH HHS United States
HD010333 NICHD NIH HHS United States
MH085812 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Body Height genetics
Female genetics
Genetic Pleiotropy genetics
Humans genetics
Intelligence genetics
Male genetics
Models, Genetic genetics
Reproduction genetics
Statistics as Topic genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3617178 NLM