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PMID |
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TITLE |
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Genetic variants associated with disordered eating. |
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ABSTRACT |
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OBJECTIVE |
NlmCategory: OBJECTIVE |
Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders. |
METHOD |
NlmCategory: METHODS |
Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders. We conducted genome-wide association analyses in 2,564 female twins for four different phenotypes derived from self-report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene-based association tests using VEGAS software. |
RESULTS |
NlmCategory: RESULTS |
Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders. We conducted genome-wide association analyses in 2,564 female twins for four different phenotypes derived from self-report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene-based association tests using VEGAS software. Although no variants reached genome-wide significance at the level of p < 10(-8), six regions were suggestive (p < 5 × 10(-7)). The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype. |
DISCUSSION |
NlmCategory: CONCLUSIONS |
Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders. We conducted genome-wide association analyses in 2,564 female twins for four different phenotypes derived from self-report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene-based association tests using VEGAS software. Although no variants reached genome-wide significance at the level of p < 10(-8), six regions were suggestive (p < 5 × 10(-7)). The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype. As with other medical and psychiatric phenotypes, much larger samples and meta-analyses will ultimately be needed to identify genes and pathways contributing to predisposition to eating disorders. |
© 2013 Wiley Periodicals, Inc. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
accepted |
2013/02/04 |
entrez |
2013/04/10 06:00 |
pubmed |
2013/04/10 06:00 |
medline |
2014/02/28 06:00 |
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AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Wade TD |
|
Wade |
Tracey D |
TD |
|
School of Psychology, Flinders University, Adelaide, South Australia, Australia. |
Gordon S |
|
Gordon |
Scott |
S |
|
|
Medland S |
|
Medland |
Sarah |
S |
|
|
Bulik CM |
|
Bulik |
Cynthia M |
CM |
|
|
Heath AC |
|
Heath |
Andrew C |
AC |
|
|
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
Martin NG |
|
Martin |
Nicholas G |
NG |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 46 |
ISSUE: 6 |
TITLE: The International journal of eating disorders |
ISOABBREVIATION: Int J Eat Disord |
YEAR: 2013 |
MONTH: Sep |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1098-108X |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Int J Eat Disord |
COUNTRY: United States |
ISSNLINKING: 0276-3478 |
NLMUNIQUEID: 8111226 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
DA019951 |
NIDA NIH HHS |
United States |
R01 AA007535 |
NIAAA NIH HHS |
United States |
R01 AA014041 |
NIAAA NIH HHS |
United States |
K05 AA017688 |
NIAAA NIH HHS |
United States |
AA13320 |
NIAAA NIH HHS |
United States |
P50 AA011998 |
NIAAA NIH HHS |
United States |
R01 AA007728 |
NIAAA NIH HHS |
United States |
AA13321 |
NIAAA NIH HHS |
United States |
R56 DA012854 |
NIDA NIH HHS |
United States |
AA17688 |
NIAAA NIH HHS |
United States |
DA012854 |
NIDA NIH HHS |
United States |
R01 AA013321 |
NIAAA NIH HHS |
United States |
AA07728 |
NIAAA NIH HHS |
United States |
AA11998 |
NIAAA NIH HHS |
United States |
R01 DA012854 |
NIDA NIH HHS |
United States |
K08 DA019951 |
NIDA NIH HHS |
United States |
R37 AA007728 |
NIAAA NIH HHS |
United States |
AA14041 |
NIAAA NIH HHS |
United States |
R01 AA013320 |
NIAAA NIH HHS |
United States |
|
GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
anorexia nervosa |
genes |
genome-wide association study |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Feeding and Eating Disorders |
genetics |
Female |
genetics |
Genome-Wide Association Study |
genetics |
Genotype |
genetics |
Humans |
genetics |
Phenotype |
genetics |
Surveys and Questionnaires |
genetics |
Twins |
genetics |
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SUPPLEMENTARY MESH |
|
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GENE SYMBOLS |
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CHEMICALS |
|
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OTHER ID's |
|
|
|