Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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23563607
TITLE
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
ABSTRACT
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
DATE PUBLISHED
2013 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/10/16
accepted 2013/03/14
aheadofprint 2013/04/07
entrez 2013/04/09 06:00
pubmed 2013/04/09 06:00
medline 2013/06/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Berndt SI Berndt Sonja I SI US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Gustafsson S Gustafsson Stefan S
Mägi R Mägi Reedik R
Ganna A Ganna Andrea A
Wheeler E Wheeler Eleanor E
Feitosa MF Feitosa Mary F MF
Justice AE Justice Anne E AE
Monda KL Monda Keri L KL
Croteau-Chonka DC Croteau-Chonka Damien C DC
Day FR Day Felix R FR
Esko T Esko Tõnu T
Fall T Fall Tove T
Ferreira T Ferreira Teresa T
Gentilini D Gentilini Davide D
Jackson AU Jackson Anne U AU
Luan J Luan Jian'an J
Randall JC Randall Joshua C JC
Vedantam S Vedantam Sailaja S
Willer CJ Willer Cristen J CJ
Winkler TW Winkler Thomas W TW
Wood AR Wood Andrew R AR
Workalemahu T Workalemahu Tsegaselassie T
Hu YJ Hu Yi-Juan YJ
Lee SH Lee Sang Hong SH
Liang L Liang Liming L
Lin DY Lin Dan-Yu DY
Min JL Min Josine L JL
Neale BM Neale Benjamin M BM
Thorleifsson G Thorleifsson Gudmar G
Yang J Yang Jian J
Albrecht E Albrecht Eva E
Amin N Amin Najaf N
Bragg-Gresham JL Bragg-Gresham Jennifer L JL
Cadby G Cadby Gemma G
den Heijer M den Heijer Martin M
Eklund N Eklund Niina N
Fischer K Fischer Krista K
Goel A Goel Anuj A
Hottenga JJ Hottenga Jouke-Jan JJ
Huffman JE Huffman Jennifer E JE
Jarick I Jarick Ivonne I
Johansson Å Johansson Åsa
Johnson T Johnson Toby T
Kanoni S Kanoni Stavroula S
Kleber ME Kleber Marcus E ME
König IR König Inke R IR
Kristiansson K Kristiansson Kati K
Kutalik Z Kutalik Zoltán Z
Lamina C Lamina Claudia C
Lecoeur C Lecoeur Cecile C
Li G Li Guo G
Mangino M Mangino Massimo M
McArdle WL McArdle Wendy L WL
Medina-Gomez C Medina-Gomez Carolina C
Müller-Nurasyid M Müller-Nurasyid Martina M
Ngwa JS Ngwa Julius S JS
Nolte IM Nolte Ilja M IM
Paternoster L Paternoster Lavinia L
Pechlivanis S Pechlivanis Sonali S
Perola M Perola Markus M
Peters MJ Peters Marjolein J MJ
Preuss M Preuss Michael M
Rose LM Rose Lynda M LM
Shi J Shi Jianxin J
Shungin D Shungin Dmitry D
Smith AV Smith Albert Vernon AV
Strawbridge RJ Strawbridge Rona J RJ
Surakka I Surakka Ida I
Teumer A Teumer Alexander A
Trip MD Trip Mieke D MD
Tyrer J Tyrer Jonathan J
Van Vliet-Ostaptchouk JV Van Vliet-Ostaptchouk Jana V JV
Vandenput L Vandenput Liesbeth L
Waite LL Waite Lindsay L LL
Zhao JH Zhao Jing Hua JH
Absher D Absher Devin D
Asselbergs FW Asselbergs Folkert W FW
Atalay M Atalay Mustafa M
Attwood AP Attwood Antony P AP
Balmforth AJ Balmforth Anthony J AJ
Basart H Basart Hanneke H
Beilby J Beilby John J
Bonnycastle LL Bonnycastle Lori L LL
Brambilla P Brambilla Paolo P
Bruinenberg M Bruinenberg Marcel M
Campbell H Campbell Harry H
Chasman DI Chasman Daniel I DI
Chines PS Chines Peter S PS
Collins FS Collins Francis S FS
Connell JM Connell John M JM
Cookson WO Cookson William O WO
de Faire U de Faire Ulf U
de Vegt F de Vegt Femmie F
Dei M Dei Mariano M
Dimitriou M Dimitriou Maria M
Edkins S Edkins Sarah S
Estrada K Estrada Karol K
Evans DM Evans David M DM
Farrall M Farrall Martin M
Ferrario MM Ferrario Marco M MM
Ferrières J Ferrières Jean J
Franke L Franke Lude L
Frau F Frau Francesca F
Gejman PV Gejman Pablo V PV
Grallert H Grallert Harald H
Grönberg H Grönberg Henrik H
Gudnason V Gudnason Vilmundur V
Hall AS Hall Alistair S AS
Hall P Hall Per P
Hartikainen AL Hartikainen Anna-Liisa AL
Hayward C Hayward Caroline C
Heard-Costa NL Heard-Costa Nancy L NL
Heath AC Heath Andrew C AC
Hebebrand J Hebebrand Johannes J
Homuth G Homuth Georg G
Hu FB Hu Frank B FB
Hunt SE Hunt Sarah E SE
Hyppönen E Hyppönen Elina E
Iribarren C Iribarren Carlos C
Jacobs KB Jacobs Kevin B KB
Jansson JO Jansson John-Olov JO
Jula A Jula Antti A
Kähönen M Kähönen Mika M
Kathiresan S Kathiresan Sekar S
Kee F Kee Frank F
Khaw KT Khaw Kay-Tee KT
Kivimäki M Kivimäki Mika M
Koenig W Koenig Wolfgang W
Kraja AT Kraja Aldi T AT
Kumari M Kumari Meena M
Kuulasmaa K Kuulasmaa Kari K
Kuusisto J Kuusisto Johanna J
Laitinen JH Laitinen Jaana H JH
Lakka TA Lakka Timo A TA
Langenberg C Langenberg Claudia C
Launer LJ Launer Lenore J LJ
Lind L Lind Lars L
Lindström J Lindström Jaana J
Liu J Liu Jianjun J
Liuzzi A Liuzzi Antonio A
Lokki ML Lokki Marja-Liisa ML
Lorentzon M Lorentzon Mattias M
Madden PA Madden Pamela A PA
Magnusson PK Magnusson Patrik K PK
Manunta P Manunta Paolo P
Marek D Marek Diana D
März W März Winfried W
Mateo Leach I Mateo Leach Irene I
McKnight B McKnight Barbara B
Medland SE Medland Sarah E SE
Mihailov E Mihailov Evelin E
Milani L Milani Lili L
Montgomery GW Montgomery Grant W GW
Mooser V Mooser Vincent V
Mühleisen TW Mühleisen Thomas W TW
Munroe PB Munroe Patricia B PB
Musk AW Musk Arthur W AW
Narisu N Narisu Narisu N
Navis G Navis Gerjan G
Nicholson G Nicholson George G
Nohr EA Nohr Ellen A EA
Ong KK Ong Ken K KK
Oostra BA Oostra Ben A BA
Palmer CN Palmer Colin N A CN
Palotie A Palotie Aarno A
Peden JF Peden John F JF
Pedersen N Pedersen Nancy N
Peters A Peters Annette A
Polasek O Polasek Ozren O
Pouta A Pouta Anneli A
Pramstaller PP Pramstaller Peter P PP
Prokopenko I Prokopenko Inga I
Pütter C Pütter Carolin C
Radhakrishnan A Radhakrishnan Aparna A
Raitakari O Raitakari Olli O
Rendon A Rendon Augusto A
Rivadeneira F Rivadeneira Fernando F
Rudan I Rudan Igor I
Saaristo TE Saaristo Timo E TE
Sambrook JG Sambrook Jennifer G JG
Sanders AR Sanders Alan R AR
Sanna S Sanna Serena S
Saramies J Saramies Jouko J
Schipf S Schipf Sabine S
Schreiber S Schreiber Stefan S
Schunkert H Schunkert Heribert H
Shin SY Shin So-Youn SY
Signorini S Signorini Stefano S
Sinisalo J Sinisalo Juha J
Skrobek B Skrobek Boris B
Soranzo N Soranzo Nicole N
Stančáková A Stančáková Alena A
Stark K Stark Klaus K
Stephens JC Stephens Jonathan C JC
Stirrups K Stirrups Kathleen K
Stolk RP Stolk Ronald P RP
Stumvoll M Stumvoll Michael M
Swift AJ Swift Amy J AJ
Theodoraki EV Theodoraki Eirini V EV
Thorand B Thorand Barbara B
Tregouet DA Tregouet David-Alexandre DA
Tremoli E Tremoli Elena E
Van der Klauw MM Van der Klauw Melanie M MM
van Meurs JB van Meurs Joyce B J JB
Vermeulen SH Vermeulen Sita H SH
Viikari J Viikari Jorma J
Virtamo J Virtamo Jarmo J
Vitart V Vitart Veronique V
Waeber G Waeber Gérard G
Wang Z Wang Zhaoming Z
Widén E Widén Elisabeth E
Wild SH Wild Sarah H SH
Willemsen G Willemsen Gonneke G
Winkelmann BR Winkelmann Bernhard R BR
Witteman JC Witteman Jacqueline C M JC
Wolffenbuttel BH Wolffenbuttel Bruce H R BH
Wong A Wong Andrew A
Wright AF Wright Alan F AF
Zillikens MC Zillikens M Carola MC
Amouyel P Amouyel Philippe P
Boehm BO Boehm Bernhard O BO
Boerwinkle E Boerwinkle Eric E
Boomsma DI Boomsma Dorret I DI
Caulfield MJ Caulfield Mark J MJ
Chanock SJ Chanock Stephen J SJ
Cupples LA Cupples L Adrienne LA
Cusi D Cusi Daniele D
Dedoussis GV Dedoussis George V GV
Erdmann J Erdmann Jeanette J
Eriksson JG Eriksson Johan G JG
Franks PW Franks Paul W PW
Froguel P Froguel Philippe P
Gieger C Gieger Christian C
Gyllensten U Gyllensten Ulf U
Hamsten A Hamsten Anders A
Harris TB Harris Tamara B TB
Hengstenberg C Hengstenberg Christian C
Hicks AA Hicks Andrew A AA
Hingorani A Hingorani Aroon A
Hinney A Hinney Anke A
Hofman A Hofman Albert A
Hovingh KG Hovingh Kees G KG
Hveem K Hveem Kristian K
Illig T Illig Thomas T
Jarvelin MR Jarvelin Marjo-Riitta MR
Jöckel KH Jöckel Karl-Heinz KH
Keinanen-Kiukaanniemi SM Keinanen-Kiukaanniemi Sirkka M SM
Kiemeney LA Kiemeney Lambertus A LA
Kuh D Kuh Diana D
Laakso M Laakso Markku M
Lehtimäki T Lehtimäki Terho T
Levinson DF Levinson Douglas F DF
Martin NG Martin Nicholas G NG
Metspalu A Metspalu Andres A
Morris AD Morris Andrew D AD
Nieminen MS Nieminen Markku S MS
Njølstad I Njølstad Inger I
Ohlsson C Ohlsson Claes C
Oldehinkel AJ Oldehinkel Albertine J AJ
Ouwehand WH Ouwehand Willem H WH
Palmer LJ Palmer Lyle J LJ
Penninx B Penninx Brenda B
Power C Power Chris C
Province MA Province Michael A MA
Psaty BM Psaty Bruce M BM
Qi L Qi Lu L
Rauramaa R Rauramaa Rainer R
Ridker PM Ridker Paul M PM
Ripatti S Ripatti Samuli S
Salomaa V Salomaa Veikko V
Samani NJ Samani Nilesh J NJ
Snieder H Snieder Harold H
Sørensen TI Sørensen Thorkild I A TI
Spector TD Spector Timothy D TD
Stefansson K Stefansson Kari K
Tönjes A Tönjes Anke A
Tuomilehto J Tuomilehto Jaakko J
Uitterlinden AG Uitterlinden André G AG
Uusitupa M Uusitupa Matti M
van der Harst P van der Harst Pim P
Vollenweider P Vollenweider Peter P
Wallaschofski H Wallaschofski Henri H
Wareham NJ Wareham Nicholas J NJ
Watkins H Watkins Hugh H
Wichmann HE Wichmann H-Erich HE
Wilson JF Wilson James F JF
Abecasis GR Abecasis Goncalo R GR
Assimes TL Assimes Themistocles L TL
Barroso I Barroso Inês I
Boehnke M Boehnke Michael M
Borecki IB Borecki Ingrid B IB
Deloukas P Deloukas Panos P
Fox CS Fox Caroline S CS
Frayling T Frayling Timothy T
Groop LC Groop Leif C LC
Haritunian T Haritunian Talin T
Heid IM Heid Iris M IM
Hunter D Hunter David D
Kaplan RC Kaplan Robert C RC
Karpe F Karpe Fredrik F
Moffatt MF Moffatt Miriam F MF
Mohlke KL Mohlke Karen L KL
O'Connell JR O'Connell Jeffrey R JR
Pawitan Y Pawitan Yudi Y
Schadt EE Schadt Eric E EE
Schlessinger D Schlessinger David D
Steinthorsdottir V Steinthorsdottir Valgerdur V
Strachan DP Strachan David P DP
Thorsteinsdottir U Thorsteinsdottir Unnur U
van Duijn CM van Duijn Cornelia M CM
Visscher PM Visscher Peter M PM
Di Blasio AM Di Blasio Anna Maria AM
Hirschhorn JN Hirschhorn Joel N JN
Lindgren CM Lindgren Cecilia M CM
Morris AP Morris Andrew P AP
Meyre D Meyre David D
Scherag A Scherag André A
McCarthy MI McCarthy Mark I MI
Speliotes EK Speliotes Elizabeth K EK
North KE North Kari E KE
Loos RJ Loos Ruth J F RJ
Ingelsson E Ingelsson Erik E
INVESTIGATORS
JOURNAL
VOLUME: 45
ISSUE: 5
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2013
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
097117 Wellcome Trust United Kingdom
14136 Cancer Research UK United Kingdom
CZB/4/710 Chief Scientist Office United Kingdom
G0600237 Medical Research Council United Kingdom
G0601261 Medical Research Council United Kingdom
G1000143 Medical Research Council United Kingdom
G1002084 Medical Research Council United Kingdom
G9521010 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MC_PC_U127561128 Medical Research Council United Kingdom
MC_U105260558 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106179472 Medical Research Council United Kingdom
MC_U106188470 Medical Research Council United Kingdom
MC_U123092720 Medical Research Council United Kingdom
MR/K006584/1 Medical Research Council United Kingdom
P60 DK020541 NIDDK NIH HHS United States
R01 DK072193 NIDDK NIH HHS United States
R01 DK075787 NIDDK NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
R01 HL117626 NHLBI NIH HHS United States
T32 GM074905 NIGMS NIH HHS United States
U01 HG007416 NHGRI NIH HHS United States
Cancer Research UK United Kingdom
Medical Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Anthropometry
Body Height genetics
Body Mass Index genetics
Case-Control Studies genetics
European Continental Ancestry Group genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Genotype genetics
Humans genetics
Meta-Analysis as Topic genetics
Obesity genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Quantitative Trait Loci genetics
Waist-Hip Ratio genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS536922 NLM
PMC3973018 NLM