Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23558354
TITLE
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent.
ABSTRACT
Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.
DATE PUBLISHED
2013 Aug 1
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2013/04/04
entrez 2013/04/06 06:00
pubmed 2013/04/06 06:00
medline 2013/09/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Fernández-Rhodes L Fernández-Rhodes Lindsay L Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 137 East Franklin Street, Suite 306, Campus Box 8050, Chapel Hill, NC 27514-8050, USA. fernandez-rhodes@unc.edu
Demerath EW Demerath Ellen W EW
Cousminer DL Cousminer Diana L DL
Tao R Tao Ran R
Dreyfus JG Dreyfus Jill G JG
Esko T Esko Tõnu T
Smith AV Smith Albert V AV
Gudnason V Gudnason Vilmundur V
Harris TB Harris Tamara B TB
Launer L Launer Lenore L
McArdle PF McArdle Patrick F PF
Yerges-Armstrong LM Yerges-Armstrong Laura M LM
Elks CE Elks Cathy E CE
Strachan DP Strachan David P DP
Kutalik Z Kutalik Zoltán Z
Vollenweider P Vollenweider Peter P
Feenstra B Feenstra Bjarke B
Boyd HA Boyd Heather A HA
Metspalu A Metspalu Andres A
Mihailov E Mihailov Evelin E
Broer L Broer Linda L
Zillikens MC Zillikens M Carola MC
Oostra B Oostra Ben B
van Duijn CM van Duijn Cornelia M CM
Lunetta KL Lunetta Kathryn L KL
Perry JR Perry John R B JR
Murray A Murray Anna A
Koller DL Koller Daniel L DL
Lai D Lai Dongbing D
Corre T Corre Tanguy T
Toniolo D Toniolo Daniela D
Albrecht E Albrecht Eva E
Stöckl D Stöckl Doris D
Grallert H Grallert Harald H
Gieger C Gieger Christian C
Hayward C Hayward Caroline C
Polasek O Polasek Ozren O
Rudan I Rudan Igor I
Wilson JF Wilson James F JF
He C He Chunyan C
Kraft P Kraft Peter P
Hu FB Hu Frank B FB
Hunter DJ Hunter David J DJ
Hottenga JJ Hottenga Jouke-Jan JJ
Willemsen G Willemsen Gonneke G
Boomsma DI Boomsma Dorret I DI
Byrne EM Byrne Enda M EM
Martin NG Martin Nicholas G NG
Montgomery GW Montgomery Grant W GW
Warrington NM Warrington Nicole M NM
Pennell CE Pennell Craig E CE
Stolk L Stolk Lisette L
Visser JA Visser Jenny A JA
Hofman A Hofman Albert A
Uitterlinden AG Uitterlinden André G AG
Rivadeneira F Rivadeneira Fernando F
Lin P Lin Peng P
Fisher SL Fisher Sherri L SL
Bierut LJ Bierut Laura J LJ
Crisponi L Crisponi Laura L
Porcu E Porcu Eleonora E
Mangino M Mangino Massimo M
Zhai G Zhai Guangju G
Spector TD Spector Tim D TD
Buring JE Buring Julie E JE
Rose LM Rose Lynda M LM
Ridker PM Ridker Paul M PM
Poole C Poole Charles C
Hirschhorn JN Hirschhorn Joel N JN
Murabito JM Murabito Joanne M JM
Chasman DI Chasman Daniel I DI
Widen E Widen Elisabeth E
North KE North Kari E KE
Ong KK Ong Ken K KK
Franceschini N Franceschini Nora N
INVESTIGATORS
JOURNAL
VOLUME: 178
ISSUE: 3
TITLE: American journal of epidemiology
ISOABBREVIATION: Am. J. Epidemiol.
YEAR: 2013
MONTH: Aug
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-6256
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Epidemiol
COUNTRY: United States
ISSNLINKING: 0002-9262
NLMUNIQUEID: 7910653
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
092447/Z/10/Z Wellcome Trust United Kingdom
5T32HL007055 NHLBI NIH HHS United States
CZB/4/710 Chief Scientist Office United Kingdom
K02 DA021237 NIDA NIH HHS United States
K02 DA021237 NIDA NIH HHS United States
MC_U106179472 Medical Research Council United Kingdom
P01 CA089392 NCI NIH HHS United States
R01 DA013423 NIDA NIH HHS United States
R01 DA019963 NIDA NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
T32 HL007779 NHLBI NIH HHS United States
T32HL007779 NHLBI NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
U10 AA008401 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
adiposity
body mass index
genetic association studies
menarche
obesity
waist circumference
waist:hip ratio
women's health
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adiposity genetics
Adolescent genetics
Age Factors genetics
Body Mass Index genetics
Child genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Association Studies genetics
Humans genetics
Linkage Disequilibrium genetics
Menarche genetics
Obesity genetics
Polymorphism, Single Nucleotide genetics
Waist Circumference genetics
Waist-Hip Ratio genetics
Women's Health statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3816344 NLM