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| PMID |
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| TITLE |
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| Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. |
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| ABSTRACT |
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| Genome-wide association studies (GWAS) of attention-deficit/hyperactivity disorder (ADHD) offer the benefit of a hypothesis-free approach to measuring the quantitative effect of genetic variants on affection status. Generally the findings of GWAS relying on ADHD status have been non-significant, but the one study using quantitative measures of symptoms found SLC9A9 and SLC6A1 were associated with inattention and hyperactivity-impulsivity. Accordingly, we performed a GWAS using quantitative measures of each ADHD subtype measured with the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) scale in two community-based samples. This scale captures the full range of attention and kinetic behavior; from high levels of attention and appropriate activity to the inattention and hyperactivity-impulsivity associated with ADHD within two community-based samples. Our discovery sample comprised 1,851 participants (mean age = 22.8 years [4.8]; 50.6% female), while our replication sample comprised 155 participants (mean age = 26.3 years [3.1]; 68.4% females). Age, sex, age × sex, and age2 were included as covariates and the results from each sample were combined using meta-analysis, then analyzed with a gene-based test to estimate the combined effect of markers within genes. We compare our results with markers that have previously been found to have a strong association with ADHD symptoms. Neither the GWAS nor subsequent meta-analyses yielded genome-wide significant results; the strongest effect was observed at rs2110267 (4.62 × 10-7) for symptoms of hyperactivity-impulsivity. The strongest effect in the gene-based test was for GPR139 on symptoms of inattention (6.40 × 10-5). Replication of this study with larger samples will add to our understanding of the genetic etiology of ADHD. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2013/03/27 06:00 |
| pubmed |
2013/03/27 06:00 |
| medline |
2013/06/19 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ebejer JL |
|
Ebejer |
Jane L |
JL |
|
School of Environmental and Rural Sciences, University of New England, Armidale, New South Wales, Australia. jebejer@une.edu.au |
| Duffy DL |
|
Duffy |
David L |
DL |
|
|
| van der Werf J |
|
van der Werf |
Julius |
J |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Montgomery G |
|
Montgomery |
Grant |
G |
|
|
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
|
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 16 |
| ISSUE: 2 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2013 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R00DA023549 |
NIDA NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
|
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Attention Deficit Disorder with Hyperactivity |
psychology |
| Australia |
epidemiology |
| Cohort Studies |
epidemiology |
| Diseases in Twins |
genetics |
| Female |
genetics |
| Genetics, Behavioral |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Impulsive Behavior |
genetics |
| Male |
genetics |
| Phenotype |
genetics |
| Quantitative Trait, Heritable |
genetics |
| Registries |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
|
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| OTHER ID's |
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