Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23527679
TITLE
Shared genetic vulnerability for disordered gambling and alcohol use disorder in men and women: evidence from a national community-based Australian Twin Study.
ABSTRACT
Disordered gambling (DG) will soon be included along with the substance use disorders in a revised diagnostic category of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 called 'Substance Use and Addictive Disorders'. This was premised in part on the common etiologies of DG and the substance use disorders. Using data from the national community-based Australian Twin Registry, we used biometric model fitting to examine the extent to which the genetic liabilities for DG and alcohol use disorder (AUD) were shared, and whether this differed for men and women. The effect of using categorical versus dimensional DG and AUD phenotypes was explored, as was the effect of using diagnoses based on the DSM-IV and the proposed DSM-5 diagnostic criteria. The genetic correlations between DG and AUD ranged from 0.29 to 0.44. There was a significantly larger genetic correlation between DG and AUD among men than women when using dimensional phenotypes. Overall, about one-half to two-thirds of the association between DG and AUD was due to a shared genetic vulnerability. This study represents one of the few empirical demonstrations of an overlap in the genetic risk for DG and another substance-related addictive disorder. More research is needed on the genetic overlap between DG and other substance use disorders, as well as the genetic overlap between DG and other (non-substance-related) psychiatric disorders.
DATE PUBLISHED
2013 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2013/03/27 06:00
pubmed 2013/03/27 06:00
medline 2013/06/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Slutske WS Slutske Wendy S WS Department of Psychological Sciences, University of Missouri, Columbia, MO, USA. SlutskeW@missouri.edu
Ellingson JM Ellingson Jarrod M JM
Richmond-Rakerd LS Richmond-Rakerd Leah S LS
Zhu G Zhu Gu G
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 16
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2013
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Addiction. 2006 Sep;101 Suppl 1:142-51 16930171
Cites Addiction. 2006 Sep;101 Suppl 1:152-60 16930172
Cites Int J Methods Psychiatr Res. 2007;16 Suppl 1:S24-33 17623392
Cites Int J Methods Psychiatr Res. 2007;16 Suppl 1:S8-S15 17623398
Cites PLoS Comput Biol. 2008 Jan;4(1):e2 18179280
Cites Drug Alcohol Depend. 2008 Apr 1;94(1-3):234-45 18215474
Cites Psychol Med. 2008 Sep;38(9):1351-60 18257941
Cites Am J Addict. 2008 Sep-Oct;17(5):392-5 18770081
Cites Twin Res Hum Genet. 2009 Feb;12(1):63-78 19210181
Cites Cereb Cortex. 2009 Jun;19(6):1303-12 18842666
Cites Science. 2010 Feb 19;327(5968):935 20167757
Cites Ann N Y Acad Sci. 2010 Feb;1187:294-315 20201859
Cites Arch Gen Psychiatry. 2010 Jun;67(6):624-30 20530012
Cites Am J Drug Alcohol Abuse. 2010 Sep;36(5):233-41 20560821
Cites Eur J Neurosci. 2011 May;33(9):1706-15 21453423
Cites Eur J Public Health. 2011 Aug;21(4):532-7 19892851
Cites J Abnorm Psychol. 2011 Aug;120(3):743-51 21443290
Cites Psychol Bull. 2011 Sep;137(5):856-79 21574681
Cites Addiction. 2011 Nov;106(11):1935-43 21631621
Cites J Nerv Ment Dis. 2011 Dec;199(12):956-60 22134454
Cites Nat Neurosci. 2012 Feb;15(2):181-9 22281715
Cites Drug Alcohol Depend. 2012 Sep 1;125(1-2):75-80 22516145
Cites J Abnorm Psychol. 2013 Feb;122(1):250-5 22985012
Cites Addict Biol. 2013 May;18(3):511-22 22780124
Cites Addiction. 1999 May;94(5):697-707 10563034
Cites Arch Gen Psychiatry. 2000 Jul;57(7):666-73 10891037
Cites J Abnorm Psychol. 2001 May;110(2):297-308 11358024
Cites Addict Behav. 2002 Sep-Oct;27(5):819-35 12201386
Cites Addict Behav. 2004 Feb;29(2):323-35 14732420
Cites Addict Behav. 2004 Nov;29(8):1685-90 15451138
Cites Subst Use Misuse. 2004 Jul;39(9):1405-22 15462237
Cites Cereb Cortex. 2004 Nov;14(11):1226-32 15142963
Cites Am J Psychiatry. 1987 Sep;144(9):1184-8 3631315
Cites Am J Public Health. 1999 Sep;89(9):1369-76 10474555
Cites J Clin Psychiatry. 2005 May;66(5):564-74 15889941
Cites Am J Psychiatry. 2005 Aug;162(8):1414-22 16055762
Cites J Gambl Stud. 2005 Fall;21(3):299-324 16134010
Cites Nat Neurosci. 2005 Nov;8(11):1445-9 16251986
Cites Brain. 2005 Dec;128(Pt 12):2872-81 16195242
Cites Psychol Med. 2006 Jul;36(7):943-53 16650342
GRANTS
GRANTID AGENCY COUNTRY
MH66206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcohol-Related Disorders psychology
Australia epidemiology
Cohort Studies epidemiology
Community-Based Participatory Research epidemiology
Diagnostic and Statistical Manual of Mental Disorders epidemiology
Diseases in Twins epidemiology
Female epidemiology
Gambling psychology
Gene-Environment Interaction psychology
Humans psychology
Impulse Control Disorders psychology
Male psychology
Phenotype psychology
Registries psychology
Social Environment psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS559433 NLM
PMC3974625 NLM