Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23427138
TITLE
A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations.
ABSTRACT
Delta opioid receptors are implicated in a variety of psychiatric and neurological disorders. These receptors play a key role in the reinforcing properties of drugs of abuse, and polymorphisms in OPRD1 (the gene encoding delta opioid receptors) are associated with drug addiction. Delta opioid receptors are also involved in protecting neurons against hypoxic and ischemic stress. Here, we first examined a large sample of 738 elderly participants with neuroimaging and genetic data from the Alzheimer's Disease Neuroimaging Initiative. We hypothesized that common variants in OPRD1 would be associated with differences in brain structure, particularly in regions relevant to addictive and neurodegenerative disorders. One very common variant (rs678849) predicted differences in regional brain volumes. We replicated the association of this single-nucleotide polymorphism with regional tissue volumes in a large sample of young participants in the Queensland Twin Imaging study. Although the same allele was associated with reduced volumes in both cohorts, the brain regions affected differed between the two samples. In healthy elderly, exploratory analyses suggested that the genotype associated with reduced brain volumes in both cohorts may also predict cerebrospinal fluid levels of neurodegenerative biomarkers, but this requires confirmation. If opiate receptor genetic variants are related to individual differences in brain structure, genotyping of these variants may be helpful when designing clinical trials targeting delta opioid receptors to treat neurological disorders.
Copyright © 2013 Wiley Periodicals, Inc.
DATE PUBLISHED
2014 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/07/23
revised 2012/11/01
accepted 2012/11/30
aheadofprint 2013/02/21
entrez 2013/02/22 06:00
pubmed 2013/02/22 06:00
medline 2014/12/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Roussotte FF Roussotte Florence F FF Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Pediatrics, Developmental Cognitive Neuroimaging Laboratory (DCNL), University of Southern California, Los Angeles, California.
Jahanshad N Jahanshad Neda N
Hibar DP Hibar Derrek P DP
Sowell ER Sowell Elizabeth R ER
Kohannim O Kohannim Omid O
Barysheva M Barysheva Marina M
Hansell NK Hansell Narelle K NK
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Jack CR Jr Jack Clifford R CR
Weiner MW Weiner Michael W MW
Thompson PM Thompson Paul M PM
ADNI
INVESTIGATORS
JOURNAL
VOLUME: 35
ISSUE: 4
TITLE: Human brain mapping
ISOABBREVIATION: Hum Brain Mapp
YEAR: 2014
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1097-0193
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Brain Mapp
COUNTRY: United States
ISSNLINKING: 1065-9471
NLMUNIQUEID: 9419065
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Biol Psychiatry. 2009 Jan 15;65(2):160-4 18801475
Cites Neuroimage. 2008 Nov 15;43(3):458-69 18691658
Cites Alcohol Clin Exp Res. 2010 Feb;34(2):214-22 19951300
Cites Cell Res. 2010 Feb;20(2):138-53 20066010
Cites Nat Genet. 2010 Apr;42(4):348-54 20208533
Cites Neuroimage. 2010 Jun;51(2):542-54 20197096
Cites Alzheimers Dement. 2010 May;6(3):230-8 20451871
Cites J Pharmacol Exp Ther. 2010 Oct;335(1):133-9 20605909
Cites Mol Cell Biol. 2011 Jun;31(11):2326-40 21464208
Cites Biochem Biophys Res Commun. 2011 Jun 10;409(3):520-5 21600884
Cites J Neurosci. 2011 Jul 27;31(30):10882-90 21795540
Cites Trends Pharmacol Sci. 2011 Oct;32(10):581-90 21925742
Cites Biol Psychiatry. 2012 Feb 1;71(3):232-8 21889123
Cites Drug Alcohol Depend. 2012 Apr 1;122(1-2):156-9 22018601
Cites J Neurosci. 2012 Mar 28;32(13):4540-52 22457501
Cites Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E851-9 22232660
Cites Nat Genet. 2012 May;44(5):552-61 22504417
Cites Hum Genet. 2012 Jun;131(6):823-42 22547174
Cites Curr Top Behav Neurosci. 2012;11:1-24 22016109
Cites Drug Alcohol Depend. 2012 Jul 1;124(1-2):142-8 22270405
Cites Neuropsychopharmacology. 2012 Aug;37(9):2012-9 22510721
Cites Acta Neuropathol. 2012 Sep;124(3):305-23 22618995
Cites Drug Alcohol Depend. 2013 Jan 1;127(1-3):122-8 22795689
Cites Nature. 2000 Mar 9;404(6774):190-3 10724172
Cites Cereb Cortex. 2000 Mar;10(3):334-42 10731228
Cites Neuroimage. 2001 Sep;14(3):595-606 11506533
Cites Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322 11545704
Cites Neuroimage. 2002 Oct;17(2):825-41 12377157
Cites Hum Brain Mapp. 2002 Nov;17(3):143-55 12391568
Cites Curr Top Med Chem. 2004;4(1):1-17 14754373
Cites Magn Reson Imaging. 2004 Jul;22(6):769-77 15234445
Cites J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 8126267
Cites Science. 1994 Sep 30;265(5181):2037-48 8091226
Cites IEEE Trans Med Imaging. 1998 Feb;17(1):87-97 9617910
Cites J Comput Assist Tomogr. 1998 Sep-Oct;22(5):838-43 9754126
Cites Bioinformatics. 2005 Jan 15;21(2):263-5 15297300
Cites Neuroscience. 2005;135(1):213-25 16111831
Cites Neuroimage. 2006 Apr 1;30(2):436-43 16300968
Cites Neuroimage. 2006 Jun;31(2):627-40 16480900
Cites Trends Pharmacol Sci. 2006 Jun;27(6):324-9 16678916
Cites Inf Process Med Imaging. 2005;19:493-503 17354720
Cites Addiction. 2007 Apr;102 Suppl 1:33-43 17493051
Cites Neuroimage. 2007 Oct 15;38(1):43-56 17825583
Cites J Magn Reson Imaging. 2008 Apr;27(4):685-91 18302232
Cites Mol Psychiatry. 2008 May;13(5):531-43 17622222
Cites Neuroimage. 2008 May 15;41(1):19-34 18378167
Cites Sheng Li Xue Bao. 2009 Dec 25;61(6):585-92 20029693
GRANTS
GRANTID AGENCY COUNTRY
1F30AG041681 NIA NIH HHS United States
F30 AG041681 NIA NIH HHS United States
K01 AG030514 NIA NIH HHS United States
K01 AG030514 NIA NIH HHS United States
P30 AG010129 NIA NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 MH097268 NIMH NIH HHS United States
R01 MH097268 NIMH NIH HHS United States
U01 AG024904 NIA NIH HHS United States
U01 AG024904 NIA NIH HHS United States
U24 AG021886 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
drug addiction
genetics
neurodegeneration
neuroimaging
opiates
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Aged
Aging pathology
Alzheimer Disease pathology
Biomarkers cerebrospinal fluid
Brain pathology
Databases, Factual pathology
Female pathology
Genotyping Techniques pathology
Humans pathology
Image Processing, Computer-Assisted pathology
Linkage Disequilibrium pathology
Magnetic Resonance Imaging pathology
Male pathology
Mild Cognitive Impairment pathology
Organ Size pathology
Polymorphism, Single Nucleotide pathology
Receptors, Opioid, delta genetics
Twin Studies as Topic genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biomarkers
0 OPRD1 protein, human
0 Receptors, Opioid, delta
OTHER ID's
OTHERID SOURCE
NIHMS504323 NLM
PMC4046708 NLM
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