Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23417127
TITLE
No association between general cognitive ability and rare copy number variation.
ABSTRACT
There is increasing evidence for the role of rare copy-number variation (CNV) in the development of neuropsychiatric disorders. It is likely that such variants also have an effect on the variation of cognition in what is considered the "normal" phenotypic range. The role of rare CNV (>20 KB in length; frequency <5 %) on general cognitive ability is investigated in a sample of 800 individuals (mean age = 16.5, SD = 1.2) using copy-number variants called from the Illumina 610K SNP genotyping array with the software QuantiSNP. We assessed three measures of CNV burden--total CNV length, number of CNV and average CNV length--for both deletions and duplications in combination and separately. No correlation was found between any of the measures of CNV burden and IQ, or when comparing the top and bottom 10 % of the sample for IQ, both on a genome-wide scale and at individual positions across the genome.
DATE PUBLISHED
2013 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/13
accepted 2013/02/06
aheadofprint 2013/02/17
entrez 2013/02/19 06:00
pubmed 2013/02/19 06:00
medline 2013/11/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McRae AF McRae Allan F AF University of Queensland Diamantina Institute, Brisbane, QLD, Australia. a.mcrae@uq.edu.au
Wright MJ Wright Margaret J MJ
Hansell NK Hansell Narelle K NK
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 3
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2013
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Cognition physiology
DNA Copy Number Variations genetics
Female genetics
Gene Dosage genetics
Genome-Wide Association Study genetics
Humans genetics
Intelligence genetics
Intelligence Tests genetics
Male genetics
Polymorphism, Single Nucleotide genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's