Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23397253
TITLE
Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups.
ABSTRACT
A large part of the variation in cognitive ability is known to be due to genetic factors. Researchers have tried to identify modifiers that influence the heritability of cognitive ability, indicating a genotype by environment interaction (GĂ?E). To date, such modifiers include measured variables like income and socioeconomic status. The present paper focuses on GĂ?E in cognitive ability where the environmental variable is an unmeasured environmental factor that is uncorrelated in family members. We examined this type of GĂ?E in the GHCA-database (Haworth et al., Behav Genet 39:359-370, 2009), which comprises data of 14 different cognition studies from four different countries including participants of different ages. Results indicate that for younger participants (4-13 years), the strength of E decreases across the additive genetic factor A, but that this effect reverts for older participants (17-34 years). However, a clear and general conclusion about the presence of a genuine GĂ?E is hampered by differences between the individual studies with respect to environmental and genetic influences on cognitive ability.
DATE PUBLISHED
2013 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/08/30
accepted 2012/12/17
aheadofprint 2013/02/10
entrez 2013/02/12 06:00
pubmed 2013/02/12 06:00
medline 2013/11/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Molenaar D Molenaar Dylan D Psychological Methods, Department of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands. d.molenaar@uva.nl
van der Sluis S van der Sluis Sophie S
Boomsma DI Boomsma Dorret I DI
Haworth CM Haworth Claire M A CM
Hewitt JK Hewitt John K JK
Martin NG Martin Nicholas G NG
Plomin R Plomin Robert R
Wright MJ Wright Margaret J MJ
Dolan CV Dolan Conor V CV
INVESTIGATORS
JOURNAL
VOLUME: 43
ISSUE: 3
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2013
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA009367 NIAAA NIH HHS United States
DA011015 NIDA NIH HHS United States
G0500079 Medical Research Council United Kingdom
G0500079 Medical Research Council United Kingdom
G0500079(73692) Medical Research Council United Kingdom
HD027802 NICHD NIH HHS United States
HD038075 NICHD NIH HHS United States
HD044454 NICHD NIH HHS United States
HD046167 NICHD NIH HHS United States
HD11681 NICHD NIH HHS United States
P50 HD027802 NICHD NIH HHS United States
P60 DA011015 NIDA NIH HHS United States
R01 AA009367 NIAAA NIH HHS United States
R01 DA005147 NIDA NIH HHS United States
R01 DA013240 NIDA NIH HHS United States
R01 DA013240 NIDA NIH HHS United States
R01 HD010333 NICHD NIH HHS United States
R01 HD038075 NICHD NIH HHS United States
R01 HD044454 NICHD NIH HHS United States
R01 HD046167 NICHD NIH HHS United States
R37 DA005147 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Child
Child, Preschool
Cognition
Female
Gene-Environment Interaction
Genotype
Humans
Intelligence genetics
Intelligence Tests genetics
Male genetics
Models, Genetic genetics
Risk Factors genetics
Social Class genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS561949 NLM
PMC4015869 NLM