Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23321625
TITLE
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect.
ABSTRACT
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19,713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r=0.42; P-value=3.60 × 10(-61)) than father-offspring correlation (r=0.33; P-value=7.01 × 10(-5)), and a significant positive association with paternal age at offspring birth (β=0.005; P-value=7.01 × 10(-5)). Interestingly, a significant and quite substantial correlation in TL between spouses (r=0.25; P-value=2.82 × 10(-30)) was seen, which appeared stronger in older spouse pairs (mean age ≥55 years; r=0.31; P-value=4.27 × 10(-23)) than in younger pairs (mean age<55 years; r=0.20; P-value=3.24 × 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age.
DATE PUBLISHED
2013 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/09/04
revised 2012/11/08
accepted 2012/11/13
aheadofprint 2013/01/16
entrez 2013/01/17 06:00
pubmed 2013/01/17 06:00
medline 2014/05/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Broer L Broer Linda L 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands.
Codd V Codd Veryan V
Nyholt DR Nyholt Dale R DR
Deelen J Deelen Joris J
Mangino M Mangino Massimo M
Willemsen G Willemsen Gonneke G
Albrecht E Albrecht Eva E
Amin N Amin Najaf N
Beekman M Beekman Marian M
de Geus EJ de Geus Eco J C EJ
Henders A Henders Anjali A
Nelson CP Nelson Christopher P CP
Steves CJ Steves Claire J CJ
Wright MJ Wright Margie J MJ
de Craen AJ de Craen Anton J M AJ
Isaacs A Isaacs Aaron A
Matthews M Matthews Mary M
Moayyeri A Moayyeri Alireza A
Montgomery GW Montgomery Grant W GW
Oostra BA Oostra Ben A BA
Vink JM Vink Jacqueline M JM
Spector TD Spector Tim D TD
Slagboom PE Slagboom P Eline PE
Martin NG Martin Nicholas G NG
Samani NJ Samani Nilesh J NJ
van Duijn CM van Duijn Cornelia M CM
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 21
ISSUE: 10
TITLE: European journal of human genetics : EJHG
ISOABBREVIATION: Eur. J. Hum. Genet.
YEAR: 2013
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5438
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur J Hum Genet
COUNTRY: England
ISSNLINKING: 1018-4813
NLMUNIQUEID: 9302235
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Hum Genet. 2006 Mar;78(3):480-6 16400618
Cites Epidemiology. 2006 Mar;17(2):190-4 16477260
Cites Int J Epidemiol. 2013 Feb;42(1):76-85 22253318
Cites Age (Dordr). 2013 Feb;35(1):235-49 22113349
Cites PLoS Genet. 2006 Aug 25;2(8):e132 16934002
Cites PLoS Genet. 2008 Feb;4(2):e37 18282113
Cites Twin Res Hum Genet. 2006 Dec;9(6):849-57 17254420
Cites Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12135-9 17623782
Cites Aging Cell. 2007 Dec;6(6):769-74 17925004
Cites Hum Mol Genet. 2007 Dec 15;16(24):3097-102 17881651
Cites Am J Epidemiol. 2008 Apr 1;167(7):799-806 18270372
Cites Nature. 1999 Dec 2;402(6761):551-5 10591218
Cites Biol Reprod. 2000 Aug;63(2):591-8 10906069
Cites Cell. 2001 Sep 21;106(6):661-73 11572773
Cites Nucleic Acids Res. 2002 May 15;30(10):e47 12000852
Cites Lancet. 2003 Feb 1;361(9355):393-5 12573379
Cites Lancet. 2004 Feb 14;363(9408):507-10 14975611
Cites Eur J Hum Genet. 2004 Jul;12(7):527-34 15054401
Cites J Mol Biol. 1978 Mar 25;120(1):33-53 642006
Cites Mutat Res. 1991 Jan;256(1):45-8 1944386
Cites Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10114-8 1438199
Cites Am J Hum Genet. 1994 Nov;55(5):876-82 7977349
Cites Am J Hum Genet. 2005 Jan;76(1):147-51 15520935
Cites Aging Cell. 2005 Apr;4(2):97-101 15771613
Cites Ann Hum Genet. 2005 May;69(Pt 3):288-95 15845033
Cites Twin Res Hum Genet. 2005 Oct;8(5):433-9 16212832
Cites Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16374-8 16258070
Cites Aging Cell. 2005 Dec;4(6):287-90 16300480
Cites Eur J Hum Genet. 2006 Jan;14(1):79-84 16251894
Cites Hypertension. 2008 Jun;51(6):1658-64 18443236
Cites Nat Genet. 2009 Feb;41(2):221-7 19151717
Cites Am J Hum Genet. 2009 Nov;85(5):750-5 19896111
Cites Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1710-7 19915151
Cites Eur J Hum Genet. 2010 Mar;18(3):385-9 19826452
Cites Nat Genet. 2010 Mar;42(3):197-9 20139977
Cites Twin Res Hum Genet. 2010 Jun;13(3):231-45 20477721
Cites Proc Natl Acad Sci U S A. 2010 May 18;107(20):9293-8 20421499
Cites Hum Mutat. 2010 Sep;31(9):1050-8 20597107
Cites Heredity (Edinb). 2010 Dec;105(6):497-506 20736972
Cites Eur J Hum Genet. 2011 Jun;19(6):721-3 21304559
Cites Aging Cell. 2012 Apr;11(2):223-7 22136229
Cites Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10251-6 22689985
Cites Nature. 2012 Aug 23;488(7412):471-5 22914163
CommentIn Eur J Hum Genet. 2014 Jan;22(1):8-9 24022299
CommentIn Eur J Hum Genet. 2015 Jan;23(1):3-4 24755952
CommentIn Eur J Hum Genet. 2014 Jan;22(1):10-1 24149546
GRANTS
GRANTID AGENCY COUNTRY
British Heart Foundation United Kingdom
Department of Health United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Inheritance Patterns
Male
Middle Aged
Paternal Age
Pedigree
Telomere genetics
Telomere Shortening genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3778341 NLM
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