PMID |
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TITLE |
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Test-retest reliability of graph theory measures of structural brain connectivity. |
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ABSTRACT |
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The human connectome has recently become a popular research topic in neuroscience, and many new algorithms have been applied to analyze brain networks. In particular, network topology measures from graph theory have been adapted to analyze network efficiency and 'small-world' properties. While there has been a surge in the number of papers examining connectivity through graph theory, questions remain about its test-retest reliability (TRT). In particular, the reproducibility of structural connectivity measures has not been assessed. We examined the TRT of global connectivity measures generated from graph theory analyses of 17 young adults who underwent two high-angular resolution diffusion (HARDI) scans approximately 3 months apart. Of the measures assessed, modularity had the highest TRT, and it was stable across a range of sparsities (a thresholding parameter used to define which network edges are retained). These reliability measures underline the need to develop network descriptors that are robust to acquisition parameters. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
entrez |
2013/01/05 06:00 |
pubmed |
2013/01/05 06:00 |
medline |
2013/01/30 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Dennis EL |
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Dennis |
Emily L |
EL |
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Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA, CA, USA. |
Jahanshad N |
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Jahanshad |
Neda |
N |
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Toga AW |
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Toga |
Arthur W |
AW |
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McMahon KL |
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McMahon |
Katie L |
KL |
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de Zubicaray GI |
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de Zubicaray |
Greig I |
GI |
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Martin NG |
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Martin |
Nicholas G |
NG |
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Wright MJ |
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Wright |
Margaret J |
MJ |
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Thompson PM |
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Thompson |
Paul M |
PM |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 15 |
ISSUE: Pt 3 |
TITLE: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention |
ISOABBREVIATION: Med Image Comput Comput Assist Interv |
YEAR: 2012 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: |
ISSNTYPE: |
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MEDLINE JOURNAL |
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MEDLINETA: Med Image Comput Comput Assist Interv |
COUNTRY: Germany |
ISSNLINKING: 1433-7851 |
NLMUNIQUEID: 101249582 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
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22106308 |
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Cites |
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Cites |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
P41 RR013642 |
NCRR NIH HHS |
United States |
R01 EB007813 |
NIBIB NIH HHS |
United States |
R01 EB008281 |
NIBIB NIH HHS |
United States |
R01 EB008432 |
NIBIB NIH HHS |
United States |
R01 HD050735 |
NICHD NIH HHS |
United States |
T32 MH073526 |
NIMH NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Algorithms |
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Brain |
anatomy & histology |
Connectome |
methods |
Diffusion Tensor Imaging |
methods |
Female |
methods |
Humans |
methods |
Image Enhancement |
methods |
Image Interpretation, Computer-Assisted |
methods |
Male |
methods |
Nerve Fibers, Myelinated |
ultrastructure |
Nerve Net |
anatomy & histology |
Reproducibility of Results |
anatomy & histology |
Sensitivity and Specificity |
anatomy & histology |
Young Adult |
anatomy & histology |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS575977 |
NLM |
PMC4039303 |
NLM |
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