Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23278275
TITLE
Effects of sibship size and composition on younger brothers' and sisters' alcohol use initiation: findings from an Australian twin sample.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The effects of sibship size and structure on delinquency are well established. Specifically, having a large family and many brothers has been shown to predict offending. However, despite strong links between delinquency and alcohol use, the contribution of sibship factors to drinking behaviors remains largely unexplored. The current study investigated the impact of sibship size and composition on younger brothers' and sisters' ages of drinking and intoxication onset.
METHODS NlmCategory: METHODS
We employed a sample of 4,281 same-sex twins from the Australian Twin Register to examine whether (i) large sibship size facilitates earlier age at first drink (AFD) and age at first intoxication (AFI) in males and females, (ii) having many older brothers predicts earlier ages of AFD and AFI in males, and (iii) having many older brothers results in later AFD and AFI in females. We tested whether effects were moderated by parental divorce and alcohol misuse and mediated by familial religion.
RESULTS NlmCategory: RESULTS
Sibling effects were minimal before accounting for family context. However, when parental divorce and excessive parental drinking were included as moderators, sibling effects were significantly amplified among individuals from homes of divorce, and effects were strongest when siblings were close in age.
CONCLUSIONS NlmCategory: CONCLUSIONS
Strong close in age older sibling effects indicate that proximal sibling attitudes and behaviors about alcohol likely interact with structural factors to influence younger siblings' drinking. Sibship factors were much more influential in one population (individuals from homes of divorce) than another (respondents with a parental history of excessive drinking), suggesting that sibling effects vary depending on the type of co-occurring familial risk. Prevention efforts performed at the family level, and introduced before first use of alcohol, are likely to delay drinking initiation and help prevent future alcohol problems.
Copyright © 2012 by the Research Society on Alcoholism.
DATE PUBLISHED
2013 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/12
accepted 2012/09/26
aheadofprint 2012/12/27
entrez 2013/01/03 06:00
pubmed 2013/01/03 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA. lr526@mail.missouri.edu
Slutske WS Slutske Wendy S WS
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 6
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2013
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA013526 NIAAA NIH HHS United States
K05 AA017242 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH 66206 NIMH NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Alcohol Drinking epidemiology
Alcoholic Intoxication epidemiology
Alcoholism epidemiology
Birth Intervals statistics & numerical data
Cohort Studies statistics & numerical data
Conduct Disorder epidemiology
Family Characteristics epidemiology
Female epidemiology
Humans epidemiology
Male epidemiology
Middle Aged epidemiology
Sex Factors epidemiology
Siblings epidemiology
Social Environment epidemiology
Surveys and Questionnaires epidemiology
Twins epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS423007 NLM
PMC3631572 NLM