Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23278275
TITLE
Effects of sibship size and composition on younger brothers' and sisters' alcohol use initiation: findings from an Australian twin sample.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The effects of sibship size and structure on delinquency are well established. Specifically, having a large family and many brothers has been shown to predict offending. However, despite strong links between delinquency and alcohol use, the contribution of sibship factors to drinking behaviors remains largely unexplored. The current study investigated the impact of sibship size and composition on younger brothers' and sisters' ages of drinking and intoxication onset.
METHODS NlmCategory: METHODS
We employed a sample of 4,281 same-sex twins from the Australian Twin Register to examine whether (i) large sibship size facilitates earlier age at first drink (AFD) and age at first intoxication (AFI) in males and females, (ii) having many older brothers predicts earlier ages of AFD and AFI in males, and (iii) having many older brothers results in later AFD and AFI in females. We tested whether effects were moderated by parental divorce and alcohol misuse and mediated by familial religion.
RESULTS NlmCategory: RESULTS
Sibling effects were minimal before accounting for family context. However, when parental divorce and excessive parental drinking were included as moderators, sibling effects were significantly amplified among individuals from homes of divorce, and effects were strongest when siblings were close in age.
CONCLUSIONS NlmCategory: CONCLUSIONS
Strong close in age older sibling effects indicate that proximal sibling attitudes and behaviors about alcohol likely interact with structural factors to influence younger siblings' drinking. Sibship factors were much more influential in one population (individuals from homes of divorce) than another (respondents with a parental history of excessive drinking), suggesting that sibling effects vary depending on the type of co-occurring familial risk. Prevention efforts performed at the family level, and introduced before first use of alcohol, are likely to delay drinking initiation and help prevent future alcohol problems.
Copyright 2012 by the Research Society on Alcoholism.
DATE PUBLISHED
2013 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/12
accepted 2012/09/26
aheadofprint 2012/12/27
entrez 2013/01/03 06:00
pubmed 2013/01/03 06:00
medline 2013/10/18 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA. lr526@mail.missouri.edu
Slutske WS Slutske Wendy S WS
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 6
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2013
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Child Adolesc Psychiatr Clin N Am. 2000 Oct;9(4):733-48 11005003
Cites Br J Psychiatry. 1980 Feb;136:139-45 7370480
Cites Alcohol Clin Exp Res. 2001 Aug;25(8):1166-73 11515563
Cites J Subst Abuse. 2001;13(4):493-504 11775078
Cites Alcohol Clin Exp Res. 1986 Jun;10(3):274-8 3526950
Cites J R Soc Med. 1993 Jan;86(1):13-7 8423566
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Addiction. 1994 Aug;89(8):1007-16 7950847
Cites Alcohol Clin Exp Res. 1995 Dec;19(6):1480-5 8749814
Cites Health Psychol. 1997 Sep;16(5):426-32 9302539
Cites J Abnorm Psychol. 1998 Aug;107(3):363-74 9715572
Cites Am J Med Genet. 1999 Aug 20;88(4):391-7 10402507
Cites J Abnorm Child Psychol. 2004 Dec;32(6):635-49 15648530
Cites Alcohol Clin Exp Res. 2005 Feb;29(2):207-20 15714044
Cites Psychol Med. 2004 Nov;34(8):1519-30 15724882
Cites J Stud Alcohol. 2006 May;67(3):391-8 16608148
Cites Behav Genet. 2006 Jul;36(4):483-97 16586152
Cites Ann N Y Acad Sci. 2006 Dec;1094:193-201 17347351
Cites Addict Behav. 2007 Sep;32(9):1814-25 17289280
Cites Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 17481828
Cites J Abnorm Psychol. 2008 Feb;117(1):63-78 18266486
Cites Addict Behav. 2009 Jun-Jul;34(6-7):526-30 19386422
Cites J Stud Alcohol Drugs. 2009 Jul;70(4):623-7 19515304
Cites Alcohol Alcohol. 2002 Jan-Feb;37(1):74-80 11825861
Cites JAMA. 2003 Jan 22-29;289(4):427-33 12533121
Cites J Child Psychol Psychiatry. 1975 Apr;16(2):125-40 1127050
Cites Child Dev. 2001 Jan-Feb;72(1):271-83 11280484
GRANTS
GRANTID AGENCY COUNTRY
AA007535 NIAAA NIH HHS United States
AA013526 NIAAA NIH HHS United States
K05 AA017242 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH 66206 NIMH NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Alcohol Drinking epidemiology
Alcoholic Intoxication epidemiology
Alcoholism epidemiology
Birth Intervals statistics & numerical data
Cohort Studies statistics & numerical data
Conduct Disorder epidemiology
Family Characteristics epidemiology
Female epidemiology
Humans epidemiology
Male epidemiology
Middle Aged epidemiology
Sex Factors epidemiology
Siblings epidemiology
Social Environment epidemiology
Surveys and Questionnaires epidemiology
Twins epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS423007 NLM
PMC3631572 NLM