Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23277915
TITLE
Investigating the influence of prenatal androgen exposure and sibling effects on alcohol use and alcohol use disorder in females from opposite-sex twin pairs.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
There are robust sex differences for alcohol phenotypes, with men reporting more drinking and alcohol use disorder (AUD) symptoms than women. However, the sources of these effects are not completely understood. Sex hormones, a substantial biological sex difference, exert neurobehavioral influences and are candidates for influencing sex differences in alcohol phenotypes. This study investigated the effects of prenatal androgens based on the hypothesis of prenatal hormone transfer, which posits that hormones from one twin influence the development of a cotwin.
METHODS NlmCategory: METHODS
This study compared female twins from opposite-sex (OSF) and same-sex (SSF) pairs to investigate associations between prenatal androgens and alcohol phenotypes. Additional analyses distinguished prenatal and postnatal effects by comparing OSFs and SSFs with a close-in-age older (CAO) brother.
RESULTS NlmCategory: RESULTS
OSFs endorsed more lifetime AUD symptoms than SSFs (d = 0.14). Females with a CAO brother reported greater intoxication frequency (d = 0.35), hangover frequency (d = 0.24), typical drinking quantity (d = 0.33), and max drinks (i.e., the most drinks ever consumed in a 24-hour period; d = 0.29). Controlling for postnatal effects, OSFs still endorsed more lifetime AUD symptoms than SSFs with a CAO brother (d = 0.16).
CONCLUSIONS NlmCategory: CONCLUSIONS
Prenatal exposure to a male cotwin was associated with increases in AUD symptoms, above the effect of postnatal exposure to a male sibling. Prenatal exposure to a male cotwin was not associated with increases in other alcohol-related phenotypes, but postnatal exposure to older male siblings produced medium effect sizes for indicators of alcohol consumption. Sex differences in AUDs, but not alcohol use, may be partially due to the neurodevelopmental effects of prenatal androgens. However, sibling effects may be larger than any effect of prenatal androgen exposure.
Copyright 2012 by the Research Society on Alcoholism.
DATE PUBLISHED
2013 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/02/15
accepted 2012/09/12
aheadofprint 2012/12/20
entrez 2013/01/03 06:00
pubmed 2013/01/03 06:00
medline 2013/11/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ellingson JM Ellingson Jarrod M JM Department of Psychological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA. jarrod.ellingson@mail.missouri.edu
Slutske WS Slutske Wendy S WS
Richmond-Rakerd LS Richmond-Rakerd Leah S LS
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 37
ISSUE: 5
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2013
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1530-0277
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
K05 AA017242 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
R01 MH066206 NIMH NIH HHS United States
T32 AA013526 NIAAA NIH HHS United States
T32AA13526 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcohol Drinking
Alcoholism
Androgens
Female
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects
Siblings
Twins, Dizygotic
Twins, Monozygotic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Androgens
OTHER ID's
OTHERID SOURCE
NIHMS413500 NLM
PMC3640339 NLM