Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23245376
TITLE
Examining the association of NRXN3 SNPs with borderline personality disorder phenotypes in heroin dependent cases and socio-economically disadvantaged controls.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Borderline personality disorder (BPD) and substance use disorders frequently co-occur; their dual presence predicts poor prognosis. The genetic underpinnings of BPD have not been well-characterized and could offer insight into comorbidity. The current report focuses on the association of neurexin 3 (NRXN3) single nucleotide polymorphisms (SNPs) with BPD symptoms in heroin dependent cases and controls.
METHODS NlmCategory: METHODS
The sample of the Comorbidity and Trauma Study, a genetic association study of heroin dependence, consists of Australian heroin dependent cases ascertained from opioid replacement therapy clinics and controls ascertained in nearby economically disadvantaged neighborhoods. The assessment included a screening instrument for BPD, used previously in Australian population surveys. Genotypic and BPD phenotypic data were available for 1439 cases and 507 controls. We examined the association of 1430 candidate gene SNPs with BPD phenotypes.
RESULTS NlmCategory: RESULTS
One or more NRXN3 SNPs were nominally associated with all BPD phenotypes; however, none met the conservative significance threshold we employed to correct for multiple testing. The most strongly associated SNPs included rs10144398 with identity disturbance (p=4.9×10(-5)) and rs10151731 with affective instability (p=8.8×10(-5)). The strongest association with screening positive for BPD was found for the NRXN3 SNP, rs10083466 (p=.0013). Neither the correlation of BPD phenotypes nor the linkage disequilibrium relationships of the SNPs account for the number of observed associations involving NRXN3 SNPs.
CONCLUSIONS NlmCategory: CONCLUSIONS
Our findings provide intriguing preliminary evidence for the association of NRXN3 with BPD phenotypes. The strongest associations were found for traits (i.e., affective instability; identity disturbance) also observed with other disorders.
Copyright 2012 Elsevier Ireland Ltd. All rights reserved.
DATE PUBLISHED
2013 Mar 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/27
revised 2012/11/15
accepted 2012/11/16
aheadofprint 2012/12/12
entrez 2012/12/19 06:00
pubmed 2012/12/19 06:00
medline 2013/08/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Panagopoulos VN Panagopoulos Vassilis N VN Department of Psychiatry, Washington University, School of Medicine, St. Louis, MO 63110, USA.
Trull TJ Trull Timothy J TJ
Glowinski AL Glowinski Anne L AL
Lynskey MT Lynskey Michael T MT
Heath AC Heath Andrew C AC
Agrawal A Agrawal Arpana A
Henders AK Henders Anjali K AK
Wallace L Wallace Leanne L
Todorov AA Todorov Alexandre A AA
Madden PA Madden Pamela A F PA
Moore E Moore Elizabeth E
Degenhardt L Degenhardt Louisa L
Martin NG Martin Nicholas G NG
Montgomery GW Montgomery Grant W GW
Nelson EC Nelson Elliot C EC
INVESTIGATORS
JOURNAL
VOLUME: 128
ISSUE: 3
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2013
MONTH: Mar
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-0046
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Addict Biol. 2014 Jan;19(1):111-21 22500942
Cites Genes Brain Behav. 2012 Aug;11(6):704-11 22716474
Cites Clin Psychol Rev. 2000 Mar;20(2):235-53 10721499
Cites Compr Psychiatry. 2000 Nov-Dec;41(6):416-25 11086146
Cites Soc Psychiatry Psychiatr Epidemiol. 2000 Dec;35(12):531-8 11213842
Cites J Clin Psychol. 2001 Dec;57(12):1403-19 11745584
Cites Am J Psychiatry. 2002 Feb;159(2):276-83 11823271
Cites Biol Psychiatry. 2002 Jun 15;51(12):936-50 12062877
Cites Biol Psychiatry. 2002 Jun 15;51(12):964-8 12062879
Cites J Pers Disord. 2004 Jun;18(3):226-39 15237043
Cites Arch Gen Psychiatry. 1994 Mar;51(3):215-24 8122958
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites J Clin Psychol. 1995 Nov;51(6):768-74 8778124
Cites Bioinformatics. 2005 Jan 15;21(2):263-5 15297300
Cites Soc Psychiatry Psychiatr Epidemiol. 2005 Feb;40(2):87-98 15685399
Cites Addiction. 2005 Aug;100(8):1121-30 16042642
Cites Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 16091475
Cites Nat Genet. 2005 Nov;37(11):1217-23 16244653
Cites Trends Neurosci. 2006 Jan;29(1):21-9 16337696
Cites Psychol Med. 2006 Jun;36(6):807-13 16623961
Cites J Psychiatr Res. 2006 Aug;40(5):448-53 16690085
Cites Am J Hum Genet. 2007 May;80(5):856-66 17436240
Cites Hum Mol Genet. 2007 Jun 1;16(11):1327-34 17409192
Cites Addiction. 2007 Jul;102(7):1140-6 17567402
Cites Int J Methods Psychiatr Res. 2007;16 Suppl 1:S1-5 17623390
Cites PLoS Genet. 2006 Dec;2(12):e190 17194218
Cites Am J Hum Genet. 2007 Sep;81(3):559-75 17701901
Cites Hum Mol Genet. 2007 Dec 1;16(23):2880-91 17804423
Cites Neurosci Biobehav Rev. 2008;32(4):777-810 18295884
Cites Arch Gen Psychiatry. 2008 Jun;65(6):713-21 18519829
Cites Psychol Med. 2008 Sep;38(9):1219-29 17988414
Cites Int J Psychiatry Med. 2008;38(2):217-26 18724572
Cites Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1159-66 18314870
Cites Psychol Med. 2008 Nov;38(11):1617-25 18275631
Cites Nature. 2008 Oct 16;455(7215):903-11 18923512
Cites Arch Gen Psychiatry. 2008 Dec;65(12):1438-46 19047531
Cites Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):202-8 18506706
Cites J Psychiatr Res. 2009 Aug;43(12):1036-48 19232640
Cites Psychiatry Res. 2009 Aug 30;169(1):16-21 19616307
Cites Am J Psychiatry. 2010 Jan;167(1):24-39 19952075
Cites Eur Psychiatry. 2010 Jan;25(1):19-25 19699062
Cites Behav Brain Funct. 2010;6:4 20205808
Cites Psychol Rev. 2010 Apr;117(2):623-36 20438240
Cites Am J Psychiatry. 2010 Aug;167(8):925-33 20439388
Cites Am J Psychiatry. 2010 Aug;167(8):882-5 20693463
Cites J Psychiatr Res. 2010 Nov;44(15):1075-81 20451217
Cites Addict Behav. 2011 Jan-Feb;36(1-2):27-36 20833480
Cites Curr Psychiatry Rep. 2011 Feb;13(1):69-75 21140245
Cites Lancet. 2011 Jan 1;377(9759):74-84 21195251
Cites Addiction. 2011 Feb;106(2):342-8 21083831
Cites Arch Gen Psychiatry. 2011 Aug;68(8):827-37 21464343
Cites Drug Alcohol Depend. 2011 Dec 15;119(3):e31-8 21676558
Cites Mol Neurobiol. 2011 Dec;44(3):426-40 22037798
Cites Curr Opin Neurobiol. 2012 Jun;22(3):412-22 22424845
Cites Addiction. 1999 Sep;94(9):1361-70 10615721
GRANTS
GRANTID AGENCY COUNTRY
K05 AA017688 NIAAA NIH HHS United States
R01 DA017305 NIDA NIH HHS United States
R01 DA017305 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia
Borderline Personality Disorder genetics
Case-Control Studies genetics
Female genetics
Genotype genetics
Heroin Dependence genetics
Humans genetics
Logistic Models genetics
Male genetics
Middle Aged genetics
Nerve Tissue Proteins genetics
Opiate Substitution Treatment genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Principal Component Analysis genetics
Psychiatric Status Rating Scales genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Nerve Tissue Proteins
0 neurexin IIIalpha
OTHER ID's
OTHERID SOURCE
NIHMS429608 NLM
PMC3832348 NLM