Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23211697
TITLE
Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions.
ABSTRACT
Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding genetic variants associated with personality traits. We performed a meta-analysis of four genome-wide linkage scans (N=6149 subjects) of five basic personality traits assessed with the NEO Five-Factor Inventory. We compared the significant regions from the meta-analysis of linkage scans with the results of a meta-analysis of genome-wide association studies (GWAS) (N∼17 000). We found significant evidence of linkage of neuroticism to chromosome 3p14 (rs1490265, LOD=4.67) and to chromosome 19q13 (rs628604, LOD=3.55); of extraversion to 14q32 (ATGG002, LOD=3.3); and of agreeableness to 3p25 (rs709160, LOD=3.67) and to two adjacent regions on chromosome 15, including 15q13 (rs970408, LOD=4.07) and 15q14 (rs1055356, LOD=3.52) in the individual scans. In the meta-analysis, we found strong evidence of linkage of extraversion to 4q34, 9q34, 10q24 and 11q22, openness to 2p25, 3q26, 9p21, 11q24, 15q26 and 19q13 and agreeableness to 4q34 and 19p13. Significant evidence of association in the GWAS was detected between openness and rs677035 at 11q24 (P-value=2.6 × 10(-06), KCNJ1). The findings of our linkage meta-analysis and those of the GWAS suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.
DATE PUBLISHED
2013 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2011/09/05
revised 2012/09/21
accepted 2012/10/26
aheadofprint 2012/12/05
entrez 2012/12/06 06:00
pubmed 2012/12/06 06:00
medline 2013/10/30 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Amin N Amin Najaf N Unit of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hottenga JJ Hottenga Jouke-Jan JJ
Hansell NK Hansell Narelle K NK
Janssens AC Janssens A Cecile J W AC
de Moor MH de Moor Marleen H M MH
Madden PA Madden Pamela A F PA
Zorkoltseva IV Zorkoltseva Irina V IV
Penninx BW Penninx Brenda W BW
Terracciano A Terracciano Antonio A
Uda M Uda Manuela M
Tanaka T Tanaka Toshiko T
Esko T Esko Tonu T
Realo A Realo Anu A
Ferrucci L Ferrucci Luigi L
Luciano M Luciano Michelle M
Davies G Davies Gail G
Metspalu A Metspalu Andres A
Abecasis GR Abecasis Goncalo R GR
Deary IJ Deary Ian J IJ
Raikkonen K Raikkonen Katri K
Bierut LJ Bierut Laura J LJ
Costa PT Costa Paul T PT
Saviouk V Saviouk Viatcheslav V
Zhu G Zhu Gu G
Kirichenko AV Kirichenko Anatoly V AV
Isaacs A Isaacs Aaron A
Aulchenko YS Aulchenko Yurii S YS
Willemsen G Willemsen Gonneke G
Heath AC Heath Andrew C AC
Pergadia ML Pergadia Michele L ML
Medland SE Medland Sarah E SE
Axenovich TI Axenovich Tatiana I TI
de Geus E de Geus Eco E
Montgomery GW Montgomery Grant W GW
Wright MJ Wright Margaret J MJ
Oostra BA Oostra Ben A BA
Martin NG Martin Nicholas G NG
Boomsma DI Boomsma Dorret I DI
van Duijn CM van Duijn Cornelia M CM
INVESTIGATORS
JOURNAL
VOLUME: 21
ISSUE: 8
TITLE: European journal of human genetics : EJHG
ISOABBREVIATION: Eur. J. Hum. Genet.
YEAR: 2013
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5438
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Eur J Hum Genet
COUNTRY: England
ISSNLINKING: 1018-4813
NLMUNIQUEID: 9302235
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
K05 AA017688 NIAAA NIH HHS United States
MH081802 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
R01 MH059160 NIMH NIH HHS United States
U01 HG004422 NHGRI NIH HHS United States
Z99 AG999999 Intramural NIH HHS United States
ZIA AG000180-25 Intramural NIH HHS United States
ZIA AG000180-26 Intramural NIH HHS United States
ZIA AG000196-03 Intramural NIH HHS United States
ZIA AG000196-04 Intramural NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosome Mapping methods
Chromosomes, Human, Pair 11 genetics
Genome, Human genetics
Genome-Wide Association Study methods
Humans methods
Lod Score methods
Personality genetics
Personality Inventory genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
Potassium Channels, Inwardly Rectifying genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 KCNJ1 protein, human
0 Potassium Channels, Inwardly Rectifying
OTHER ID's
OTHERID SOURCE
PMC3722675 NLM