Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
23164818
TITLE
Common variant at 16p11.2 conferring risk of psychosis.
ABSTRACT
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18 206 cases and 42 536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46 160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 × 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22 651 additional Icelanders).
DATE PUBLISHED
2014 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/06/27
revised 2012/09/14
accepted 2012/09/17
aheadofprint 2012/11/20
entrez 2012/11/21 06:00
pubmed 2012/11/21 06:00
medline 2014/08/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Steinberg S Steinberg S S deCODE genetics, Reykjavik, Iceland.
de Jong S de Jong S S Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA.
Mattheisen M Mattheisen M M 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Institute for Genomic Mathematics, University of Bonn, Bonn, Germany [3] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Costas J Costas J J Galician Foundation of Genomic Medicine-SERGAS, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.
Demontis D Demontis D D 1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Jamain S Jamain S S 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France.
Pietiläinen OP Pietiläinen O P H OP 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland [3] Wellcome Trust Sanger Institute, Cambridge, UK.
Lin K Lin K K Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.
Papiol S Papiol S S 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Huttenlocher J Huttenlocher J J 1] deCODE genetics, Reykjavik, Iceland [2] Department of Medical Genetics, Institute of Human Genetics, University of Tübingen, Tübingen, Germany.
Sigurdsson E Sigurdsson E E 1] Department of Psychiatry, National University Hospital, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.
Vassos E Vassos E E Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.
Giegling I Giegling I I Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
Breuer R Breuer R R Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Fraser G Fraser G G Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.
Walker N Walker N N Ravenscraig Hospital, Greenock, UK.
Melle I Melle I I Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
Djurovic S Djurovic S S Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
Agartz I Agartz I I Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
Tuulio-Henriksson A Tuulio-Henriksson A A Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Suvisaari J Suvisaari J J Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Lönnqvist J Lönnqvist J J Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Paunio T Paunio T T Public Health Genomics Unit, National Institute for Health and Welfare THL, Helsinki, Finland, and Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Olsen L Olsen L L Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
Hansen T Hansen T T Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
Ingason A Ingason A A Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
Pirinen M Pirinen M M Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Strengman E Strengman E E Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
GROUP
Hougaard DM Hougaard D M DM Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.
Orntoft T Orntoft T T Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Didriksen M Didriksen M M Synaptic transmission, H. Lundbeck A/S, Copenhagen, Denmark.
Hollegaard MV Hollegaard M V MV Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen, Denmark.
Nordentoft M Nordentoft M M 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Abramova L Abramova L L Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Kaleda V Kaleda V V Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Arrojo M Arrojo M M Service of Psychiatry, Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain.
Sanjuán J Sanjuán J J Unit of Psychiatry, Faculty of Medicine, University of Valencia, Network Center of Biomedical Research on Mental Health (CIBERSAM), Valencia, Spain.
Arango C Arango C C Hospital General Universitario Gregorio Marañón, IiSGM, Universidad Complutense, CIBERSAM, Madrid, Spain.
Etain B Etain B B 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
Bellivier F Bellivier F F 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.
Méary A Méary A A 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
Schürhoff F Schürhoff F F 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.
Szoke A Szoke A A 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France.
Ribolsi M Ribolsi M M Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
Magni V Magni V V Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
Siracusano A Siracusano A A Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
Sperling S Sperling S S Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Rossner M Rossner M M 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Christiansen C Christiansen C C Nordic Bioscience, Herlev, Denmark.
Kiemeney LA Kiemeney L A LA Department of Epidemiology and Biostatistics and Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Franke B Franke B B Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
van den Berg LH van den Berg L H LH Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.
Veldink J Veldink J J Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, the Netherlands.
Curran S Curran S S 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.
Bolton P Bolton P P 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College, London UK.
Poot M Poot M M Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands.
Staal W Staal W W Department of Cognitive Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands.
Rehnstrom K Rehnstrom K K 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.
Kilpinen H Kilpinen H H 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK.
Freitag CM Freitag C M CM Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Frankfurt am Main, Frankfurt am Main, Germany.
Meyer J Meyer J J Department of Neurobehavioural Genetics, University of Trier, Trier, Germany.
Magnusson P Magnusson P P Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland.
Saemundsen E Saemundsen E E State Diagnostic and Counseling Centre, Kopavogur, Iceland.
Martsenkovsky I Martsenkovsky I I Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.
Bikshaieva I Bikshaieva I I Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.
Martsenkovska I Martsenkovska I I Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.
Vashchenko O Vashchenko O O Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social, Forensic Psychiatry and Drug Abuse, Kyiv, Ukraine.
Raleva M Raleva M M Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.
Paketchieva K Paketchieva K K Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.
Stefanovski B Stefanovski B B Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.
Durmishi N Durmishi N N Department of Child and Adolescent Psychiatry, University of Skopje, Skopje, Macedonia.
Pejovic Milovancevic M Pejovic Milovancevic M M 1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.
Lecic Tosevski D Lecic Tosevski D D 1] Institute of Mental Health, Belgrade, Serbia [2] Medical Faculty, University of Belgrade, Belgrade, Serbia.
Silagadze T Silagadze T T Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
Naneishvili N Naneishvili N N Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
Mikeladze N Mikeladze N N Department of Psychiatry and Drug Addiction, Tbilisi State Medical University (TSMU), Tbilisi, Georgia.
Surguladze S Surguladze S S Social and Affective Neuroscience Lab, Ilia State University, Tbilisi, Georgia.
Vincent JB Vincent J B JB Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Farmer A Farmer A A Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK.
Mitchell PB Mitchell P B PB 1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Wright A Wright A A 1] Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia [2] School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Schofield PR Schofield P R PR 1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Fullerton JM Fullerton J M JM 1] Neuroscience Research Australia, Barker Street, Sydney, NSW, Australia [2] School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Montgomery GW Montgomery G W GW Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Martin NG Martin N G NG Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Rubino IA Rubino I A IA Section of Psychiatry, Department of Neuroscience, University of Rome-Tor Vergata, Rome, Italy.
van Winkel R van Winkel R R 1] University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium [2] Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.
Kenis G Kenis G G Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, European Graduate School of Neuroscience (EURON), South Limburg Mental Health Research and Teaching Network (SEARCH), Maastricht University Medical Center, Maastricht, The Netherlands.
De Hert M De Hert M M University Psychiatric Center, Catholic University Leuven, Kortenberg, Belgium.
Réthelyi JM Réthelyi J M JM Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Bitter I Bitter I I Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Terenius L Terenius L L Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.
Jönsson EG Jönsson E G EG Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, Stockholm, Sweden.
Bakker S Bakker S S Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.
van Os J van Os J J Department of Psychiatry, Maastricht University Medical Centre, Maastricht, The Netherlands.
Jablensky A Jablensky A A Centre for Clinical Research in Neuropsychiatry (CCRN), Graylands Hospital, the University of Western Australia, Perth, WA, Australia.
Leboyer M Leboyer M M 1] Fondation FondaMental, Créteil, France [2] INSERM U 955, Psychiatrie Génétique, Créteil, France [3] AP-HP, Hôpital H. Mondor - A. Chenevier, Pôle de Psychiatrie, Creteil France [4] Université Paris Est, Faculté de Médecine, Creteil, France.
Bramon E Bramon E E Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, London, UK.
Powell J Powell J J Department of Neuroscience, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.
Murray R Murray R R Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.
Corvin A Corvin A A Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.
Gill M Gill M M Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.
Morris D Morris D D Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College, Dublin, Ireland.
O'Neill FA O'Neill F A FA Department of Psychiatry, Queens University, Belfast, UK.
Kendler K Kendler K K 1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Riley B Riley B B 1] Department of Human Genetics, Virginia Commonwealth University, Richmond, VA, USA [2] Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA [3] Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Wellcome Trust Case Control Consortium 2
Craddock N Craddock N N MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Owen MJ Owen M J MJ MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
O'Donovan MC O'Donovan M C MC MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.
Thorsteinsdottir U Thorsteinsdottir U U 1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.
Kong A Kong A A deCODE genetics, Reykjavik, Iceland.
Ehrenreich H Ehrenreich H H 1] DFG Research Center for Molecular Physiology of the Brain (CMPB), Göttingen, Germany [2] Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Carracedo A Carracedo A A Genomic Medicine Group - Galician Foundation of Genomic Medicine-Biomedical Network Research Centre on Rare Diseases (CIBERER), University of Santiago de Compostela, Santiago de Compostela, Spain.
Golimbet V Golimbet V V Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Andreassen OA Andreassen O A OA Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo University Hospital, Oslo, Norway.
Børglum AD Børglum A D AD 1] Department of Biomedicine, Human Genetics, and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [3] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.
Mors O Mors O O 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark.
Mortensen PB Mortensen P B PB 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
Werge T Werge T T 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Institute of Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University, Roskilde, Denmark.
Ophoff RA Ophoff R A RA 1] Center for Neurobehavioral Genetics, UCLA, Los Angeles, CA, USA [2] Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands.
Nöthen MM Nöthen M M MM 1] German Center for Neurodegenerative Disorders (DZNE), Bonn Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany.
Rietschel M Rietschel M M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Cichon S Cichon S S 1] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany [2] Institute of Human Genetics, University of Bonn, Bonn Germany [3] Institute of Neurosciences and Medicine (INM-1), Juelich, Germany.
Ruggeri M Ruggeri M M Section of Psychiatry, University of Verona, Verona, Italy.
Tosato S Tosato S S Section of Psychiatry, University of Verona, Verona, Italy.
Palotie A Palotie A A 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Wellcome Trust Sanger Institute, Cambridge, UK [3] Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA [4] Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.
St Clair D St Clair D D Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, UK.
Rujescu D Rujescu D D 1] Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany [2] Department of Psychiatry, University of Halle-Wittenberg, Halle, Germany.
Collier DA Collier D A DA 1] Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK [2] Eli Lilly and Co. Ltd, Erl Wood Manor, Windlesham, Surrey, UK.
Stefansson H Stefansson H H deCODE genetics, Reykjavik, Iceland.
Stefansson K Stefansson K K 1] deCODE genetics, Reykjavik, Iceland [2] School of Medicine, University of Iceland, Reykjavik, Iceland.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Donnelly Peter P
Barroso Ines I
Blackwell Jenefer M JM
Bramon Elvira E
Brown Matthew A MA
Casas Juan P JP
Corvin Aiden A
Deloukas Panos P
Duncanson Audrey A
Jankowski Janusz J
Markus Hugh S HS
Mathew Christopher G CG
Palmer Colin N A CN
Plomin Robert R
Rautanen Anna A
Sawcer Stephen J SJ
Trembath Richard C RC
Viswanathan Ananth C AC
Wood Nicholas W NW
Spencer Chris C A CC
Band Gavin G
Bellenguez Céline C
Freeman Colin C
Hellenthal Garrett G
Giannoulatou Eleni E
Pirinen Matti M
Pearson Richard R
Strange Amy A
Su Zhan Z
Vukcevic Damjan D
Donnelly Peter P
Steinberg S S
Langford Cordelia C
Hunt Sarah E SE
Edkins Sarah S
Gwilliam Rhian R
Blackburn Hannah H
Bumpstead Suzannah J SJ
Dronov Serge S
Gillman Matthew M
Gray Emma E
Hammond Naomi N
Jayakumar Alagurevathi A
McCann Owen T OT
Liddle Jennifer J
Potter Simon C SC
Ravindrarajah Radhi R
Ricketts Michelle M
Waller Matthew M
Weston Paul P
Widaa Sara S
Whittaker Pamela P
Barroso Ines I
Deloukas Panos P
Mathew Christopher G CG
Blackwell Jenefer M JM
Brown Matthew A MA
Corvin Aiden A
Spencer Chris C A CC
JOURNAL
VOLUME: 19
ISSUE: 1
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2014
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Nat Genet. 2008 Sep;40(9):1056-8 18711365
Cites Nat Genet. 2008 Sep;40(9):1053-5 18677311
Cites Am J Hum Genet. 2009 Apr;84(4):445-58 19361613
Cites Nature. 2009 Aug 6;460(7256):744-7 19571808
Cites Nature. 2009 Aug 6;460(7256):753-7 19571809
Cites Nature. 2009 Aug 6;460(7256):748-52 19571811
Cites BMC Genomics. 2009;10:405 19712483
Cites Nat Genet. 2009 Nov;41(11):1223-7 19855392
Cites Nat Genet. 2010 Feb;42(2):128-31 20081856
Cites Nat Genet. 2010 Apr;42(4):295-302 20190752
Cites J Med Genet. 2010 May;47(5):332-41 19914906
Cites PLoS Genet. 2010 May;6(5):e1000952 20485568
Cites Am J Hum Genet. 2010 Aug 13;87(2):229-36 20691406
Cites Nat Genet. 2010 Nov;42(11):937-48 20935630
Cites BMC Psychiatry. 2010;10:91 21067598
Cites Hum Mol Genet. 2011 Jan 15;20(2):387-91 21037240
Cites Mol Psychiatry. 2011 Jan;16(1):17-25 19786961
Cites Am J Psychiatry. 2011 Mar;168(3):302-16 21285140
Cites Am J Hum Genet. 2011 Mar 11;88(3):372-81 21353194
Cites Mol Psychiatry. 2011 Apr;16(4):429-41 20368704
Cites Nature. 2011 Mar 24;471(7339):499-503 21346763
Cites Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):340-5 21234898
Cites Hum Mol Genet. 2011 Oct 15;20(20):4076-81 21791550
Cites Nat Genet. 2011 Oct;43(10):977-83 21926972
Cites Nature. 2011 Oct 6;478(7367):97-102 21881559
Cites Nature. 2011 Oct 27;478(7370):519-23 22031444
Cites Nat Genet. 2011 Dec;43(12):1228-31 22037552
Cites Nat Genet. 2011 Dec;43(12):1224-7 22037555
Cites Nature. 2012 May 17;485(7398):363-7 22596160
Cites Schizophr Res. 2012 Jun;138(1):69-73 22497794
Cites Mol Psychiatry. 2012 Sep;17(9):906-17 21747397
Cites Mol Psychiatry. 2012 Sep;17(9):880-6 22688191
Cites Biol Psychiatry. 2012 Oct 15;72(8):645-50 22560537
Cites Mol Psychiatry. 2013 Feb;18(2):195-205 22182935
Cites Mol Psychiatry. 2013 Jun;18(6):708-12 22614287
Cites Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7612-6 7644464
Cites Am J Hum Genet. 2007 Sep;81(3):559-75 17701901
Cites Mol Psychiatry. 2008 Jan;13(1):36-64 17912248
Cites Mol Psychiatry. 2008 Feb;13(2):197-207 17486107
Cites Hum Mol Genet. 2008 Feb 15;17(4):628-38 18156158
Cites Am J Hum Genet. 2008 Feb;82(2):477-88 18252227
Cites N Engl J Med. 2008 Feb 14;358(7):667-75 18184952
Cites Nature. 2008 Mar 27;452(7186):423-8 18344981
Cites Nature. 2008 Sep 11;455(7210):237-41 18668038
Cites Nature. 2008 Sep 11;455(7210):232-6 18668039
Cites Science. 2008 Nov 7;322(5903):881-8 18988837
Cites Lancet. 2009 Jan 17;373(9659):234-9 19150704
Cites Hum Mol Genet. 2009 Mar 1;18(5):988-96 18945720
GRANTS
GRANTID AGENCY COUNTRY
075491/Z/04 Wellcome Trust United Kingdom
085475/B/08/Z Wellcome Trust United Kingdom
085475/Z/08/Z Wellcome Trust United Kingdom
085475PELTONEN Wellcome Trust United Kingdom
090532 Wellcome Trust United Kingdom
098051 Wellcome Trust United Kingdom
1U24MH081810 NIMH NIH HHS United States
2N01MH080001-001 NIMH NIH HHS United States
G0601030 Medical Research Council United Kingdom
G1100583 Medical Research Council United Kingdom
MH074027 NIMH NIH HHS United States
N01 MH900001 NIMH NIH HHS United States
PG/13/66/30442 British Heart Foundation United Kingdom
R01 MH078075 NIMH NIH HHS United States
R01 MH083094 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Bipolar Disorder genetics
Chromosome Aberrations genetics
Chromosomes, Human, Pair 16 genetics
Europe genetics
Female genetics
Gene Expression Profiling genetics
Genetic Predisposition to Disease genetics
Genome-Wide Association Study genetics
Genotype genetics
Humans genetics
International Cooperation genetics
Male genetics
Middle Aged genetics
Odds Ratio genetics
Oligonucleotide Array Sequence Analysis genetics
Polymorphism, Single Nucleotide genetics
Risk Factors genetics
Schizophrenia genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
EMS54529 NLM
PMC3872086 NLM