Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
23102693
TITLE
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
ABSTRACT
Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.
Copyright 2012 Elsevier B.V. All rights reserved.
DATE PUBLISHED
2012 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/04/11
revised 2012/08/27
accepted 2012/10/07
aheadofprint 2012/10/25
entrez 2012/10/30 06:00
pubmed 2012/10/30 06:00
medline 2013/05/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Li M Li Ming M State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Wang Y Wang Yi Y
Zheng XB Zheng Xue-bin XB
Ikeda M Ikeda Masashi M
Iwata N Iwata Nakao N
Luo XJ Luo Xiong-jian XJ
Chong SA Chong Siow-Ann SA
Lee J Lee Jimmy J
Rietschel M Rietschel Marcella M
Zhang F Zhang Fengyu F
Müller-Myhsok B Müller-Myhsok Bertram B
Cichon S Cichon Sven S
Weinberger DR Weinberger Daniel R DR
Mattheisen M Mattheisen Manuel M
Schulze TG Schulze Thomas G TG
Martin NG Martin Nicholas G NG
Mitchell PB Mitchell Philip B PB
Schofield PR Schofield Peter R PR
Liu JJ Liu Jian-jun JJ
Su B Su Bing B
MooDS Consortium
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Strohmaier Jana J
Breuer René R
Meier Sandra S
Mühleisen Thomas W TW
Degenhardt Franziska A FA
Hoffmann Per P
Herms Stefan S
Schwarz Markus M
Vedder Helmut H
Kammerer-Ciernioch Jutta J
Reif Andreas A
Sasse Johanna J
Bauer Michael M
Zwick Sandra S
Hautzinger Martin M
Wright Adam A
Fullerton Janice M JM
Montgomery Grant W GW
Schumacher Johannes J
Maier Wolfgang W
Propping Peter P
Czerski Piotr M PM
Hauser Joanna J
JOURNAL
VOLUME: 142
ISSUE: 1-3
TITLE: Schizophrenia research
ISOABBREVIATION: Schizophr. Res.
YEAR: 2012
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-2509
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Schizophr Res
COUNTRY: Netherlands
ISSNLINKING:
NLMUNIQUEID: 8804207
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Asian Continental Ancestry Group
Brain pathology
Case-Control Studies pathology
European Continental Ancestry Group pathology
Female pathology
Genetic Association Studies pathology
Genetic Predisposition to Disease pathology
Humans pathology
Image Processing, Computer-Assisted pathology
Magnetic Resonance Imaging pathology
Male pathology
Middle Aged pathology
Polymorphism, Single Nucleotide genetics
Protein-Serine-Threonine Kinases genetics
Schizophrenia pathology
Young Adult pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 2.7.11.1 Protein-Serine-Threonine Kinases
EC 2.7.11.1 VRK2 protein, human
OTHER ID's