| PMID |
|
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| TITLE |
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| Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. |
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| ABSTRACT |
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| Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia. |
| Copyright © 2012 Elsevier B.V. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2012/04/11 |
| revised |
2012/08/27 |
| accepted |
2012/10/07 |
| aheadofprint |
2012/10/25 |
| entrez |
2012/10/30 06:00 |
| pubmed |
2012/10/30 06:00 |
| medline |
2013/05/08 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Li M |
|
Li |
Ming |
M |
|
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. |
| Wang Y |
|
Wang |
Yi |
Y |
|
|
| Zheng XB |
|
Zheng |
Xue-bin |
XB |
|
|
| Ikeda M |
|
Ikeda |
Masashi |
M |
|
|
| Iwata N |
|
Iwata |
Nakao |
N |
|
|
| Luo XJ |
|
Luo |
Xiong-jian |
XJ |
|
|
| Chong SA |
|
Chong |
Siow-Ann |
SA |
|
|
| Lee J |
|
Lee |
Jimmy |
J |
|
|
| Rietschel M |
|
Rietschel |
Marcella |
M |
|
|
| Zhang F |
|
Zhang |
Fengyu |
F |
|
|
| Müller-Myhsok B |
|
Müller-Myhsok |
Bertram |
B |
|
|
| Cichon S |
|
Cichon |
Sven |
S |
|
|
| Weinberger DR |
|
Weinberger |
Daniel R |
DR |
|
|
| Mattheisen M |
|
Mattheisen |
Manuel |
M |
|
|
| Schulze TG |
|
Schulze |
Thomas G |
TG |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Mitchell PB |
|
Mitchell |
Philip B |
PB |
|
|
| Schofield PR |
|
Schofield |
Peter R |
PR |
|
|
| Liu JJ |
|
Liu |
Jian-jun |
JJ |
|
|
| Su B |
|
Su |
Bing |
B |
|
|
|
MooDS Consortium |
|
|
|
|
|
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Strohmaier |
Jana |
J |
|
| Breuer |
René |
R |
|
| Meier |
Sandra |
S |
|
| Mühleisen |
Thomas W |
TW |
|
| Degenhardt |
Franziska A |
FA |
|
| Hoffmann |
Per |
P |
|
| Herms |
Stefan |
S |
|
| Schwarz |
Markus |
M |
|
| Vedder |
Helmut |
H |
|
| Kammerer-Ciernioch |
Jutta |
J |
|
| Reif |
Andreas |
A |
|
| Sasse |
Johanna |
J |
|
| Bauer |
Michael |
M |
|
| Zwick |
Sandra |
S |
|
| Hautzinger |
Martin |
M |
|
| Wright |
Adam |
A |
|
| Fullerton |
Janice M |
JM |
|
| Montgomery |
Grant W |
GW |
|
| Schumacher |
Johannes |
J |
|
| Maier |
Wolfgang |
W |
|
| Propping |
Peter |
P |
|
| Czerski |
Piotr M |
PM |
|
| Hauser |
Joanna |
J |
|
|
| JOURNAL |
|
| VOLUME: 142 |
| ISSUE: 1-3 |
| TITLE: Schizophrenia research |
| ISOABBREVIATION: Schizophr. Res. |
| YEAR: 2012 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-2509 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Schizophr Res |
| COUNTRY: Netherlands |
| ISSNLINKING: 0920-9964 |
| NLMUNIQUEID: 8804207 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Asian Continental Ancestry Group |
|
| Brain |
pathology |
| Case-Control Studies |
pathology |
| European Continental Ancestry Group |
pathology |
| Female |
pathology |
| Genetic Association Studies |
pathology |
| Genetic Predisposition to Disease |
pathology |
| Humans |
pathology |
| Image Processing, Computer-Assisted |
pathology |
| Magnetic Resonance Imaging |
pathology |
| Male |
pathology |
| Middle Aged |
pathology |
| Polymorphism, Single Nucleotide |
genetics |
| Protein-Serine-Threonine Kinases |
genetics |
| Schizophrenia |
pathology |
| Young Adult |
pathology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| EC 2.7.11.1 |
Protein-Serine-Threonine Kinases |
| EC 2.7.11.1 |
VRK2 protein, human |
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| OTHER ID's |
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