| PMID |
|
|
| TITLE |
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| A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. |
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| ABSTRACT |
|
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| Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2012/10/03 |
| entrez |
2012/10/04 06:00 |
| pubmed |
2012/10/04 06:00 |
| medline |
2013/02/16 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Surakka I |
|
Surakka |
Ida |
I |
|
Institute for Molecular Medicine, University of Helsinki, Finland. |
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
|
| Perola M |
|
Perola |
Markus |
M |
|
|
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Falchi M |
|
Falchi |
Mario |
M |
|
|
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
| Magnusson PK |
|
Magnusson |
Patrik K E |
PK |
|
|
| Christensen K |
|
Christensen |
Kaare |
K |
|
|
| Sørensen TI |
|
Sørensen |
Thorkild I A |
TI |
|
|
| Pietiläinen KH |
|
Pietiläinen |
Kirsi H |
KH |
|
|
| Rantanen T |
|
Rantanen |
Taina |
T |
|
|
| Silander K |
|
Silander |
Kaisa |
K |
|
|
| Widén E |
|
Widén |
Elisabeth |
E |
|
|
| Muilu J |
|
Muilu |
Juha |
J |
|
|
| Rahman I |
|
Rahman |
Iffat |
I |
|
|
| Liljedahl U |
|
Liljedahl |
Ulrika |
U |
|
|
| Syvänen AC |
|
Syvänen |
Ann-Christine |
AC |
|
|
| Palotie A |
|
Palotie |
Aarno |
A |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
|
| Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
|
|
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
| Spector T |
|
Spector |
Tim |
T |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Ripatti S |
|
Ripatti |
Samuli |
S |
|
|
| Peltonen L |
|
Peltonen |
Leena |
L |
|
|
|
GenomEUtwin Project |
|
|
|
|
|
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| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 15 |
| ISSUE: 6 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2012 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Clinical Trial |
| Journal Article |
| Multicenter Study |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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|
| Cites |
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| Cites |
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| Cites |
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|
| Cites |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
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| Cites |
PLoS Genet. 2009 Jun;5(6):e1000529 |
19543373 |
|
| Cites |
Nature. 2010 Aug 5;466(7307):707-13 |
20686565 |
|
| Cites |
Behav Genet. 2010 Sep;40(5):728-33 |
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|
| Cites |
PLoS Genet. 2011 Oct;7(10):e1002333 |
22028671 |
|
| Cites |
Twin Res. 2003 Oct;6(5):354-60 |
14624719 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 079771 |
Wellcome Trust |
United Kingdom |
| 098051 |
Wellcome Trust |
United Kingdom |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA10248 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| AA17688 |
NIAAA NIH HHS |
United States |
| AG028555 |
NIA NIH HHS |
United States |
| AG04563 |
NIA NIH HHS |
United States |
| AG08724 |
NIA NIH HHS |
United States |
| AG08861 |
NIA NIH HHS |
United States |
| AG10175 |
NIA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| MH66206 |
NIMH NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Alleles |
|
| Apolipoprotein A-II |
genetics |
| Cholesterol, HDL |
genetics |
| Female |
genetics |
| GTPase-Activating Proteins |
metabolism |
| Gene-Environment Interaction |
metabolism |
| Genetic Loci |
metabolism |
| Genome-Wide Association Study |
metabolism |
| Humans |
metabolism |
| Introns |
metabolism |
| Middle Aged |
metabolism |
| Polymorphism, Single Nucleotide |
metabolism |
| Twins, Monozygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Apolipoprotein A-II |
| 0 |
Cholesterol, HDL |
| 0 |
GTPase-Activating Proteins |
| 0 |
SRGAP2 protein, human |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| EMS62065 |
NLM |
| PMC4333218 |
NLM |
|
