Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23025612
TITLE
Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.
ABSTRACT
Personality traits are basic dimensions of behavioral variation, and twin, family, and adoption studies show that around 30% of the between-individual variation is due to genetic variation. There is rapidly growing interest in understanding the evolutionary basis of this genetic variation. Several evolutionary mechanisms could explain how genetic variation is maintained in traits, and each of these makes predictions in terms of the relative contribution of rare and common genetic variants to personality variation, the magnitude of nonadditive genetic influences, and whether personality is affected by inbreeding. Using genome-wide single nucleotide polymorphism (SNP) data from > 8000 individuals, we estimated that little variation in the Cloninger personality dimensions (7.2% on average) is due to the combined effect of common, additive genetic variants across the genome, suggesting that most heritable variation in personality is due to rare variant effects and/or a combination of dominance and epistasis. Furthermore, higher levels of inbreeding were associated with less socially desirable personality trait levels in three of the four personality dimensions. These findings are consistent with genetic variation in personality traits having been maintained by mutation-selection balance.
© 2012 The Author(s). Evolution© 2012 The Society for the Study of Evolution.
DATE PUBLISHED
2012 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/05/21
entrez 2012/10/03 06:00
pubmed 2012/10/03 06:00
medline 2013/02/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Verweij KJ Verweij Karin J H KJ Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Herston 4006, Brisbane, Queensland, Australia.
Yang J Yang Jian J
Lahti J Lahti Jari J
Veijola J Veijola Juha J
Hintsanen M Hintsanen Mirka M
Pulkki-Råback L Pulkki-Råback Laura L
Heinonen K Heinonen Kati K
Pouta A Pouta Anneli A
Pesonen AK Pesonen Anu-Katriina AK
Widen E Widen Elisabeth E
Taanila A Taanila Anja A
Isohanni M Isohanni Matti M
Miettunen J Miettunen Jouko J
Palotie A Palotie Aarno A
Penke L Penke Lars L
Service SK Service Susan K SK
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Raitakari O Raitakari Olli O
Kähönen M Kähönen Mika M
Viikari J Viikari Jorma J
Räikkönen K Räikkönen Katri K
Eriksson JG Eriksson Johan G JG
Keltikangas-Järvinen L Keltikangas-Järvinen Liisa L
Lehtimäki T Lehtimäki Terho T
Martin NG Martin Nicholas G NG
Järvelin MR Järvelin Marjo-Riitta MR
Visscher PM Visscher Peter M PM
Keller MC Keller Matthew C MC
Zietsch BP Zietsch Brendan P BP
INVESTIGATORS
JOURNAL
VOLUME: 66
ISSUE: 10
TITLE: Evolution; international journal of organic evolution
ISOABBREVIATION: Evolution
YEAR: 2012
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1558-5646
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Evolution
COUNTRY: United States
ISSNLINKING: 0014-3820
NLMUNIQUEID: 0373224
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
1RL1MH083268-01 NIMH NIH HHS United States
5R01HL087679-02 NHLBI NIH HHS United States
5R01MH63706:02 NIMH NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA10248 NIAAA NIH HHS United States
AA13320 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
AA14041 NIAAA NIH HHS United States
DA012854 NIDA NIH HHS United States
G0500539 Medical Research Council United Kingdom
G0600705 Medical Research Council United Kingdom
K01 MH085812 NIMH NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH66206 NIMH NIH HHS United States
RL1MH083268 NIMH NIH HHS United States
T32 NS048004 NINDS NIH HHS United States
UL1-DE019580 NIDCR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Biological Evolution
Consanguinity
Female
Genetic Variation
Humans
Male
Middle Aged
Models, Genetic
Personality genetics
Quantitative Trait, Heritable genetics
Selection, Genetic genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS425789 NLM
PMC3518920 NLM