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| PMID |
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| TITLE |
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| Genetic and environmental transmission of body mass index fluctuation. |
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| ABSTRACT |
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| This study sought to determine the relationship between body mass index (BMI) fluctuation and cardiovascular disease phenotypes, diabetes, and depression and the role of genetic and environmental factors in individual differences in BMI fluctuation using the extended twin-family model (ETFM). This study included 14,763 twins and their relatives. Health and Lifestyle Questionnaires were obtained from 28,492 individuals from the Virginia 30,000 dataset including twins, parents, siblings, spouses, and children of twins. Self-report cardiovascular disease, diabetes, and depression data were available. From self-reported height and weight, BMI fluctuation was calculated as the difference between highest and lowest BMI after age 18, for individuals 18-80 years. Logistic regression analyses were used to determine the relationship between BMI fluctuation and disease status. The ETFM was used to estimate the significance and contribution of genetic and environmental factors, cultural transmission, and assortative mating components to BMI fluctuation, while controlling for age. We tested sex differences in additive and dominant genetic effects, parental, non-parental, twin, and unique environmental effects. BMI fluctuation was highly associated with disease status, independent of BMI. Genetic effects accounted for ~34 % of variance in BMI fluctuation in males and ~43 % of variance in females. The majority of the variance was accounted for by environmental factors, about a third of which were shared among twins. Assortative mating, and cultural transmission accounted for only a small proportion of variance in this phenotype. Since there are substantial health risks associated with BMI fluctuation and environmental components of BMI fluctuation account for over 60 % of variance in males and over 50 % of variance in females, environmental risk factors may be appropriate targets to reduce BMI fluctuation. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2012/03/30 |
| accepted |
2012/09/11 |
| aheadofprint |
2012/09/26 |
| entrez |
2012/09/27 06:00 |
| pubmed |
2012/09/27 06:00 |
| medline |
2013/03/07 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bergin JE |
|
Bergin |
Jocilyn E |
JE |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, MCV, P.O. Box 980126, Richmond, VA 23298, USA. jdellava@vcu.edu |
| Neale MC |
|
Neale |
Michael C |
MC |
|
|
| Eaves LJ |
|
Eaves |
Lindon J |
LJ |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Maes HH |
|
Maes |
Hermine H |
HH |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 42 |
| ISSUE: 6 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav. Genet. |
| YEAR: 2012 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: |
| ISSNTYPE: |
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| MEDLINE JOURNAL |
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| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Health Psychol. 2000 Jan;19(1 Suppl):5-16 |
10709944 |
|
| Cites |
J Occup Environ Med. 2010 Oct;52(10):971-6 |
20881629 |
|
| Cites |
Arch Intern Med. 2001 Jul 9;161(13):1581-6 |
11434789 |
|
| Cites |
JAMA. 2003 Jan 8;289(2):187-93 |
12517229 |
|
| Cites |
JAMA. 2003 Apr 9;289(14):1813-9 |
12684360 |
|
| Cites |
JAMA. 1986 Jul 4;256(1):51-4 |
3712713 |
|
| Cites |
Infusionstherapie. 1989 Dec;16(6):276-81 |
2696728 |
|
| Cites |
N Engl J Med. 1991 Jun 27;324(26):1839-44 |
2041550 |
|
| Cites |
JAMA. 1992 Oct 21;268(15):2045-9 |
1404740 |
|
| Cites |
Ann Intern Med. 1993 Oct 1;119(7 Pt 2):749-57 |
8363210 |
|
| Cites |
Behav Genet. 1994 Jan;24(1):35-49 |
8192619 |
|
| Cites |
Int J Obes Relat Metab Disord. 1996 Jun;20(6):501-6 |
8782724 |
|
| Cites |
Behav Genet. 1997 Jul;27(4):325-51 |
9519560 |
|
| Cites |
Circ J. 2005 Jan;69(1):13-8 |
15635195 |
|
| Cites |
J Community Health. 2005 Jun;30(3):153-65 |
15847242 |
|
| Cites |
Am J Clin Nutr. 2005 Jul;82(1 Suppl):222S-225S |
16002825 |
|
| Cites |
Int J Obes (Lond). 2006 May;30(5):822-9 |
16404410 |
|
| Cites |
Behav Genet. 2006 Nov;36(6):795-808 |
16810566 |
|
| Cites |
Twin Res Hum Genet. 2009 Feb;12(1):8-18 |
19210175 |
|
| Cites |
Twin Res Hum Genet. 2009 Feb;12(1):26-34 |
19210177 |
|
| Cites |
BMJ. 2009;338:b496 |
19244221 |
|
| Cites |
Lancet. 2009 Mar 28;373(9669):1083-96 |
19299006 |
|
| Cites |
Obesity (Silver Spring). 2009 Jun;17(6):1232-9 |
19197258 |
|
| Cites |
Am J Public Health. 2009 Dec;99(12):2230-7 |
19833999 |
|
| Cites |
J Epidemiol Community Health. 2000 May;54(5):344-8 |
10814654 |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 5R37DA018673 |
NIDA NIH HHS |
United States |
| AA-06781 |
NIAAA NIH HHS |
United States |
| AG-04954 |
NIA NIH HHS |
United States |
| GM-30250 |
NIGMS NIH HHS |
United States |
| HL-48148 |
NHLBI NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| MH-40828 |
NIMH NIH HHS |
United States |
| R37 DA018673 |
NIDA NIH HHS |
United States |
| T32 MH020030 |
NIMH NIH HHS |
United States |
| T32MH20030 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
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| Adult |
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| Aged |
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| Aged, 80 and over |
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| Body Mass Index |
|
| Body Weight |
genetics |
| Cardiovascular Diseases |
genetics |
| Depression |
genetics |
| Diabetes Mellitus |
genetics |
| Environment |
genetics |
| Female |
genetics |
| Gene-Environment Interaction |
genetics |
| Humans |
genetics |
| Logistic Models |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Models, Genetic |
genetics |
| Risk Factors |
genetics |
| Siblings |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| Weight Gain |
genetics |
| Weight Loss |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS410419 |
NLM |
| PMC3474545 |
NLM |
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|
