Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23011216
TITLE
Genetic and environmental transmission of body mass index fluctuation.
ABSTRACT
This study sought to determine the relationship between body mass index (BMI) fluctuation and cardiovascular disease phenotypes, diabetes, and depression and the role of genetic and environmental factors in individual differences in BMI fluctuation using the extended twin-family model (ETFM). This study included 14,763 twins and their relatives. Health and Lifestyle Questionnaires were obtained from 28,492 individuals from the Virginia 30,000 dataset including twins, parents, siblings, spouses, and children of twins. Self-report cardiovascular disease, diabetes, and depression data were available. From self-reported height and weight, BMI fluctuation was calculated as the difference between highest and lowest BMI after age 18, for individuals 18-80 years. Logistic regression analyses were used to determine the relationship between BMI fluctuation and disease status. The ETFM was used to estimate the significance and contribution of genetic and environmental factors, cultural transmission, and assortative mating components to BMI fluctuation, while controlling for age. We tested sex differences in additive and dominant genetic effects, parental, non-parental, twin, and unique environmental effects. BMI fluctuation was highly associated with disease status, independent of BMI. Genetic effects accounted for ~34 % of variance in BMI fluctuation in males and ~43 % of variance in females. The majority of the variance was accounted for by environmental factors, about a third of which were shared among twins. Assortative mating, and cultural transmission accounted for only a small proportion of variance in this phenotype. Since there are substantial health risks associated with BMI fluctuation and environmental components of BMI fluctuation account for over 60 % of variance in males and over 50 % of variance in females, environmental risk factors may be appropriate targets to reduce BMI fluctuation.
DATE PUBLISHED
2012 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/03/30
accepted 2012/09/11
aheadofprint 2012/09/26
entrez 2012/09/27 06:00
pubmed 2012/09/27 06:00
medline 2013/03/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bergin JE Bergin Jocilyn E JE Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, MCV, P.O. Box 980126, Richmond, VA 23298, USA. jdellava@vcu.edu
Neale MC Neale Michael C MC
Eaves LJ Eaves Lindon J LJ
Martin NG Martin Nicholas G NG
Heath AC Heath Andrew C AC
Maes HH Maes Hermine H HH
INVESTIGATORS
JOURNAL
VOLUME: 42
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2012
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
5R37DA018673 NIDA NIH HHS United States
AA-06781 NIAAA NIH HHS United States
AG-04954 NIA NIH HHS United States
GM-30250 NIGMS NIH HHS United States
HL-48148 NHLBI NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
MH-40828 NIMH NIH HHS United States
R37 DA018673 NIDA NIH HHS United States
T32 MH020030 NIMH NIH HHS United States
T32MH20030 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Body Mass Index
Body Weight genetics
Cardiovascular Diseases genetics
Depression genetics
Diabetes Mellitus genetics
Environment genetics
Female genetics
Gene-Environment Interaction genetics
Humans genetics
Logistic Models genetics
Male genetics
Middle Aged genetics
Models, Genetic genetics
Risk Factors genetics
Siblings genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Weight Gain genetics
Weight Loss genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS410419 NLM
PMC3474545 NLM