Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
23010290
TITLE
Do early experiences with cannabis vary in cigarette smokers?
ABSTRACT
INTRODUCTION NlmCategory: BACKGROUND
We examine whether regular cigarette smokers were more likely to be exposed to and use cannabis at an earlier age, and further, upon initiation, whether their initial experiences with cannabis varied from those reported by never/non-regular cigarette smokers.
METHOD NlmCategory: METHODS
A sample of 3797 Australian twins and siblings aged 21-46 years was used. Survival analyses examined whether cigarette smokers were at increased likelihood of early opportunity to use cannabis and early onset of cannabis use. Logistic regression examined whether cigarette smokers reported greater enjoyment of their cannabis experience, inhaling on the first try, differing positive and negative initial subjective reactions, smoked cigarettes with cannabis the first time and were more likely to try cannabis again within a week.
RESULTS NlmCategory: RESULTS
Regular cigarette smokers were more likely to report an earlier opportunity to use cannabis and early onset of cannabis use. Regular cigarette smokers were also considerably more likely to have enjoyed their first experience with cannabis and reported higher rates of positive initial reactions. They were more likely to report inhaling on the first try and smoking cigarettes with cannabis. Potentially negative subjective reactions were also elevated in regular cigarette smokers. Importantly, cigarette smokers were at 1.87 increased odds of smoking cannabis within a week of their initial use.
CONCLUSION NlmCategory: CONCLUSIONS
These findings indicate that the well-known overlap in cannabis and cigarette smoking behaviors may evolve as early as opportunity to use and extend through the course of the substance use trajectory.
Copyright 2012 Elsevier Ireland Ltd. All rights reserved.
DATE PUBLISHED
2013 Mar 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/04/27
revised 2012/08/31
accepted 2012/09/01
aheadofprint 2012/09/23
entrez 2012/09/27 06:00
pubmed 2012/09/27 06:00
medline 2013/08/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Agrawal A Agrawal Arpana A Washington University School of Medicine, Department of Psychiatry, 660 S. Euclid, CB 8134, Saint Louis, MO 63110, USA. arpana@wustl.edu
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
Lynskey MT Lynskey Michael T MT
INVESTIGATORS
JOURNAL
VOLUME: 128
ISSUE: 3
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2013
MONTH: Mar
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-0046
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Br J Pharmacol. 2002 Jan;135(2):564-78 11815392
Cites Twin Res Hum Genet. 2012 Oct;15(5):631-41 22874079
Cites Addiction. 2003 May;98 Suppl 1:37-55 12752361
Cites Arch Gen Psychiatry. 2003 Oct;60(10):1033-9 14557149
Cites Br J Psychiatry. 1991 Nov;159:653-8 1756341
Cites Am J Public Health. 1993 Jun;83(6):851-5 8498623
Cites J Stud Alcohol. 1994 Mar;55(2):149-58 8189735
Cites Life Sci. 1995;56(23-24):2185-91 7776848
Cites Addiction. 1997 Apr;92(4):409-17 9177062
Cites Addiction. 1998 Apr;93(4):595-9 9684398
Cites J Child Psychol Psychiatry. 1998 Oct;39(7):995-1005 9804032
Cites Addict Behav. 2005 Sep;30(8):1574-86 16122618
Cites Behav Genet. 2006 Jul;36(4):507-24 16770695
Cites Am J Public Health. 2007 Nov;97(11):1981-91 17666709
Cites MMWR Morb Mortal Wkly Rep. 2007 Nov 9;56(44):1157-61 17989644
Cites PLoS Med. 2008 Jul 1;5(7):e141 18597549
Cites Drug Alcohol Depend. 2009 Nov 1;105(1-2):76-82 19628344
Cites J Stud Alcohol Drugs. 2010 Jan;71(1):5-14 20105408
Cites Drug Alcohol Depend. 2010 Apr 1;108(1-2):84-97 20060657
Cites Addiction. 2010 Apr;105(4):699-708 20148797
Cites Drug Alcohol Depend. 2010 Jun 1;109(1-3):161-6 20149559
Cites Addiction. 2011 Jan;106(1):215-24 20955487
Cites Twin Res Hum Genet. 2010 Dec;13(6):550-8 21142931
Cites Addiction. 2009 Oct;104(10):1710-7 19663900
Cites Drug Alcohol Depend. 2011 Aug 1;117(1):7-15 21288658
Cites Addiction. 2012 Jul;107(7):1221-33 22300456
Cites Behav Genet. 2012 Jul;42(4):614-25 22350186
Cites Drug Alcohol Depend. 2012 Jun;123 Suppl 1:S52-8 22445481
Cites Am J Epidemiol. 2002 May 15;155(10):918-25 11994231
GRANTS
GRANTID AGENCY COUNTRY
DA18267 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
R01DA23668 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Australia
Female
Humans
Male
Marijuana Smoking psychology
Middle Aged psychology
Proportional Hazards Models psychology
Siblings psychology
Smoking psychology
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS411501 NLM
PMC3614406 NLM