Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22986407
TITLE
How a common variant in the growth factor receptor gene, NTRK1, affects white matter.
ABSTRACT
Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses.
DATE PUBLISHED
2012 Sep-Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/09/01
entrez 2012/09/19 06:00
pubmed 2012/09/19 06:00
medline 2012/09/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Braskie MN Braskie Meredith N MN Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Jahanshad N Jahanshad Neda N Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Toga AW Toga Arthur W AW Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging; University of Queensland; Brisbane, QLD Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology; University of Queensland; Brisbane, QLD Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research; Brisbane, QLD Australia.
Wright MJ Wright Margaret J MJ Queensland Institute of Medical Research; Brisbane, QLD Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE: 5
TITLE: Bioarchitecture
ISOABBREVIATION: Bioarchitecture
YEAR:
MONTH:
DAY:
MEDLINEDATE: 2012 Sep-Oct
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Bioarchitecture
COUNTRY: United States
ISSNLINKING: 1949-0992
NLMUNIQUEID: 101518332
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AG040060 NIA NIH HHS United States
EB007813 NIBIB NIH HHS United States
EB008281 NIBIB NIH HHS United States
EB008432 NIBIB NIH HHS United States
P50 AG-16570 NIA NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
development
diffusion tensor imaging
fractional anisotropy
growth factor
myelin
neurotrophic tyrosine kinase receptor 1
neurotrophin
radial diffusivity
schizophrenia
tropomyosin-related kinase receptor A
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC3696063 NLM