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| PMID |
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| TITLE |
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| How a common variant in the growth factor receptor gene, NTRK1, affects white matter. |
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| ABSTRACT |
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| Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2012/09/01 |
| entrez |
2012/09/19 06:00 |
| pubmed |
2012/09/19 06:00 |
| medline |
2012/09/19 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Braskie MN |
|
Braskie |
Meredith N |
MN |
|
Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA. |
| Toga AW |
|
Toga |
Arthur W |
AW |
|
Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging; University of Queensland; Brisbane, QLD Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology; University of Queensland; Brisbane, QLD Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute of Medical Research; Brisbane, QLD Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Queensland Institute of Medical Research; Brisbane, QLD Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 2 |
| ISSUE: 5 |
| TITLE: Bioarchitecture |
| ISOABBREVIATION: Bioarchitecture |
| YEAR: |
| MONTH: |
| DAY: |
| MEDLINEDATE: 2012 Sep-Oct |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: |
| ISSNTYPE: |
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| MEDLINE JOURNAL |
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| MEDLINETA: Bioarchitecture |
| COUNTRY: United States |
| ISSNLINKING: 1949-0992 |
| NLMUNIQUEID: 101518332 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AG040060 |
NIA NIH HHS |
United States |
| EB007813 |
NIBIB NIH HHS |
United States |
| EB008281 |
NIBIB NIH HHS |
United States |
| EB008432 |
NIBIB NIH HHS |
United States |
| P50 AG-16570 |
NIA NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
|
| GENERAL NOTE |
|
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| KEYWORDS |
|
| KEYWORD |
| development |
| diffusion tensor imaging |
| fractional anisotropy |
| growth factor |
| myelin |
| neurotrophic tyrosine kinase receptor 1 |
| neurotrophin |
| radial diffusivity |
| schizophrenia |
| tropomyosin-related kinase receptor A |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| PMC3696063 |
NLM |
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