|
|
| PMID |
|
|
| TITLE |
|
| A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. |
|
| ABSTRACT |
|
|
|
| Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS: NCI Breast and Prostate Cancer Cohort Consortium (BPC3) (2188 ER-negative cases; 25 519 controls of European ancestry), Triple Negative Breast Cancer Consortium (TNBCC) (1562 triple negative cases; 3399 controls of European ancestry) and African American Breast Cancer Consortium (AABC) (1004 ER-negative cases; 2745 controls). We performed in silico replication of 86 SNPs at P ≤ 1 × 10(-5) in an additional 11 209 breast cancer cases (946 with ER-negative disease) and 16 057 controls of Japanese, Latino and European ancestry. We identified two novel loci for breast cancer at 20q11 and 6q14. SNP rs2284378 at 20q11 was associated with ER-negative breast cancer (combined two-stage OR = 1.16; P = 1.1 × 10(-8)) but showed a weaker association with overall breast cancer (OR = 1.08, P = 1.3 × 10(-6)) based on 17 869 cases and 43 745 controls and no association with ER-positive disease (OR = 1.01, P = 0.67) based on 9965 cases and 22 902 controls. Similarly, rs17530068 at 6q14 was associated with breast cancer (OR = 1.12; P = 1.1 × 10(-9)), and with both ER-positive (OR = 1.09; P = 1.5 × 10(-5)) and ER-negative (OR = 1.16, P = 2.5 × 10(-7)) disease. We also confirmed three known loci associated with ER-negative (19p13) and both ER-negative and ER-positive breast cancer (6q25 and 12p11). Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2012/09/13 |
| aheadofprint |
2012/10/05 |
| entrez |
2012/09/15 06:00 |
| pubmed |
2012/09/15 06:00 |
| medline |
2013/06/01 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Siddiq A |
|
Siddiq |
Afshan |
A |
|
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. |
| Couch FJ |
|
Couch |
Fergus J |
FJ |
|
|
| Chen GK |
|
Chen |
Gary K |
GK |
|
|
| Lindström S |
|
Lindström |
Sara |
S |
|
|
| Eccles D |
|
Eccles |
Diana |
D |
|
|
| Millikan RC |
|
Millikan |
Robert C |
RC |
|
|
| Michailidou K |
|
Michailidou |
Kyriaki |
K |
|
|
| Stram DO |
|
Stram |
Daniel O |
DO |
|
|
| Beckmann L |
|
Beckmann |
Lars |
L |
|
|
| Rhie SK |
|
Rhie |
Suhn Kyong |
SK |
|
|
| Ambrosone CB |
|
Ambrosone |
Christine B |
CB |
|
|
| Aittomäki K |
|
Aittomäki |
Kristiina |
K |
|
|
| Amiano P |
|
Amiano |
Pilar |
P |
|
|
| Apicella C |
|
Apicella |
Carmel |
C |
|
|
|
Australian Breast Cancer Tissue Bank Investigators |
|
|
|
|
|
| Baglietto L |
|
Baglietto |
Laura |
L |
|
|
| Bandera EV |
|
Bandera |
Elisa V |
EV |
|
|
| Beckmann MW |
|
Beckmann |
Matthias W |
MW |
|
|
| Berg CD |
|
Berg |
Christine D |
CD |
|
|
| Bernstein L |
|
Bernstein |
Leslie |
L |
|
|
| Blomqvist C |
|
Blomqvist |
Carl |
C |
|
|
| Brauch H |
|
Brauch |
Hiltrud |
H |
|
|
| Brinton L |
|
Brinton |
Louise |
L |
|
|
| Bui QM |
|
Bui |
Quang M |
QM |
|
|
| Buring JE |
|
Buring |
Julie E |
JE |
|
|
| Buys SS |
|
Buys |
Saundra S |
SS |
|
|
| Campa D |
|
Campa |
Daniele |
D |
|
|
| Carpenter JE |
|
Carpenter |
Jane E |
JE |
|
|
| Chasman DI |
|
Chasman |
Daniel I |
DI |
|
|
| Chang-Claude J |
|
Chang-Claude |
Jenny |
J |
|
|
| Chen C |
|
Chen |
Constance |
C |
|
|
| Clavel-Chapelon F |
|
Clavel-Chapelon |
Françoise |
F |
|
|
| Cox A |
|
Cox |
Angela |
A |
|
|
| Cross SS |
|
Cross |
Simon S |
SS |
|
|
| Czene K |
|
Czene |
Kamila |
K |
|
|
| Deming SL |
|
Deming |
Sandra L |
SL |
|
|
| Diasio RB |
|
Diasio |
Robert B |
RB |
|
|
| Diver WR |
|
Diver |
W Ryan |
WR |
|
|
| Dunning AM |
|
Dunning |
Alison M |
AM |
|
|
| Durcan L |
|
Durcan |
Lorraine |
L |
|
|
| Ekici AB |
|
Ekici |
Arif B |
AB |
|
|
| Fasching PA |
|
Fasching |
Peter A |
PA |
|
|
|
Familial Breast Cancer Study |
|
|
|
|
|
| Feigelson HS |
|
Feigelson |
Heather Spencer |
HS |
|
|
| Fejerman L |
|
Fejerman |
Laura |
L |
|
|
| Figueroa JD |
|
Figueroa |
Jonine D |
JD |
|
|
| Fletcher O |
|
Fletcher |
Olivia |
O |
|
|
| Flesch-Janys D |
|
Flesch-Janys |
Dieter |
D |
|
|
| Gaudet MM |
|
Gaudet |
Mia M |
MM |
|
|
|
GENICA Consortium |
|
|
|
|
|
| Gerty SM |
|
Gerty |
Susan M |
SM |
|
|
| Rodriguez-Gil JL |
|
Rodriguez-Gil |
Jorge L |
JL |
|
|
| Giles GG |
|
Giles |
Graham G |
GG |
|
|
| van Gils CH |
|
van Gils |
Carla H |
CH |
|
|
| Godwin AK |
|
Godwin |
Andrew K |
AK |
|
|
| Graham N |
|
Graham |
Nikki |
N |
|
|
| Greco D |
|
Greco |
Dario |
D |
|
|
| Hall P |
|
Hall |
Per |
P |
|
|
| Hankinson SE |
|
Hankinson |
Susan E |
SE |
|
|
| Hartmann A |
|
Hartmann |
Arndt |
A |
|
|
| Hein R |
|
Hein |
Rebecca |
R |
|
|
| Heinz J |
|
Heinz |
Judith |
J |
|
|
| Hoover RN |
|
Hoover |
Robert N |
RN |
|
|
| Hopper JL |
|
Hopper |
John L |
JL |
|
|
| Hu JJ |
|
Hu |
Jennifer J |
JJ |
|
|
| Huntsman S |
|
Huntsman |
Scott |
S |
|
|
| Ingles SA |
|
Ingles |
Sue A |
SA |
|
|
| Irwanto A |
|
Irwanto |
Astrid |
A |
|
|
| Isaacs C |
|
Isaacs |
Claudine |
C |
|
|
| Jacobs KB |
|
Jacobs |
Kevin B |
KB |
|
|
| John EM |
|
John |
Esther M |
EM |
|
|
| Justenhoven C |
|
Justenhoven |
Christina |
C |
|
|
| Kaaks R |
|
Kaaks |
Rudolf |
R |
|
|
| Kolonel LN |
|
Kolonel |
Laurence N |
LN |
|
|
| Coetzee GA |
|
Coetzee |
Gerhard A |
GA |
|
|
| Lathrop M |
|
Lathrop |
Mark |
M |
|
|
| Le Marchand L |
|
Le Marchand |
Loic |
L |
|
|
| Lee AM |
|
Lee |
Adam M |
AM |
|
|
| Lee IM |
|
Lee |
I-Min |
IM |
|
|
| Lesnick T |
|
Lesnick |
Timothy |
T |
|
|
| Lichtner P |
|
Lichtner |
Peter |
P |
|
|
| Liu J |
|
Liu |
Jianjun |
J |
|
|
| Lund E |
|
Lund |
Eiliv |
E |
|
|
| Makalic E |
|
Makalic |
Enes |
E |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| McLean CA |
|
McLean |
Catriona A |
CA |
|
|
| Meijers-Heijboer H |
|
Meijers-Heijboer |
Hanne |
H |
|
|
| Meindl A |
|
Meindl |
Alfons |
A |
|
|
| Miron P |
|
Miron |
Penelope |
P |
|
|
| Monroe KR |
|
Monroe |
Kristine R |
KR |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Müller-Myhsok B |
|
Müller-Myhsok |
Bertram |
B |
|
|
| Nickels S |
|
Nickels |
Stefan |
S |
|
|
| Nyante SJ |
|
Nyante |
Sarah J |
SJ |
|
|
| Olswold C |
|
Olswold |
Curtis |
C |
|
|
| Overvad K |
|
Overvad |
Kim |
K |
|
|
| Palli D |
|
Palli |
Domenico |
D |
|
|
| Park DJ |
|
Park |
Daniel J |
DJ |
|
|
| Palmer JR |
|
Palmer |
Julie R |
JR |
|
|
| Pathak H |
|
Pathak |
Harsh |
H |
|
|
| Peto J |
|
Peto |
Julian |
J |
|
|
| Pharoah P |
|
Pharoah |
Paul |
P |
|
|
| Rahman N |
|
Rahman |
Nazneen |
N |
|
|
| Rivadeneira F |
|
Rivadeneira |
Fernando |
F |
|
|
| Schmidt DF |
|
Schmidt |
Daniel F |
DF |
|
|
| Schmutzler RK |
|
Schmutzler |
Rita K |
RK |
|
|
| Slager S |
|
Slager |
Susan |
S |
|
|
| Southey MC |
|
Southey |
Melissa C |
MC |
|
|
| Stevens KN |
|
Stevens |
Kristen N |
KN |
|
|
| Sinn HP |
|
Sinn |
Hans-Peter |
HP |
|
|
| Press MF |
|
Press |
Michael F |
MF |
|
|
| Ross E |
|
Ross |
Eric |
E |
|
|
| Riboli E |
|
Riboli |
Elio |
E |
|
|
| Ridker PM |
|
Ridker |
Paul M |
PM |
|
|
| Schumacher FR |
|
Schumacher |
Fredrick R |
FR |
|
|
| Severi G |
|
Severi |
Gianluca |
G |
|
|
| Dos Santos Silva I |
|
Dos Santos Silva |
Isabel |
I |
|
|
| Stone J |
|
Stone |
Jennifer |
J |
|
|
| Sund M |
|
Sund |
Malin |
M |
|
|
| Tapper WJ |
|
Tapper |
William J |
WJ |
|
|
| Thun MJ |
|
Thun |
Michael J |
MJ |
|
|
| Travis RC |
|
Travis |
Ruth C |
RC |
|
|
| Turnbull C |
|
Turnbull |
Clare |
C |
|
|
| Uitterlinden AG |
|
Uitterlinden |
Andre G |
AG |
|
|
| Waisfisz Q |
|
Waisfisz |
Quinten |
Q |
|
|
| Wang X |
|
Wang |
Xianshu |
X |
|
|
| Wang Z |
|
Wang |
Zhaoming |
Z |
|
|
| Weaver J |
|
Weaver |
Joellen |
J |
|
|
| Schulz-Wendtland R |
|
Schulz-Wendtland |
Rüdiger |
R |
|
|
| Wilkens LR |
|
Wilkens |
Lynne R |
LR |
|
|
| Van Den Berg D |
|
Van Den Berg |
David |
D |
|
|
| Zheng W |
|
Zheng |
Wei |
W |
|
|
| Ziegler RG |
|
Ziegler |
Regina G |
RG |
|
|
| Ziv E |
|
Ziv |
Elad |
E |
|
|
| Nevanlinna H |
|
Nevanlinna |
Heli |
H |
|
|
| Easton DF |
|
Easton |
Douglas F |
DF |
|
|
| Hunter DJ |
|
Hunter |
David J |
DJ |
|
|
| Henderson BE |
|
Henderson |
Brian E |
BE |
|
|
| Chanock SJ |
|
Chanock |
Stephen J |
SJ |
|
|
| Garcia-Closas M |
|
Garcia-Closas |
Montserrat |
M |
|
|
| Kraft P |
|
Kraft |
Peter |
P |
|
|
| Haiman CA |
|
Haiman |
Christopher A |
CA |
|
|
| Vachon CM |
|
Vachon |
Celine M |
CM |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 21 |
| ISSUE: 24 |
| TITLE: Human molecular genetics |
| ISOABBREVIATION: Hum. Mol. Genet. |
| YEAR: 2012 |
| MONTH: Dec |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1460-2083 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Hum Mol Genet |
| COUNTRY: England |
| ISSNLINKING: 0964-6906 |
| NLMUNIQUEID: 9208958 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, N.I.H., Extramural |
| Research Support, N.I.H., Intramural |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, Non-P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 10118 |
Cancer Research UK |
United Kingdom |
| 11692 |
Cancer Research UK |
United Kingdom |
| 5U01CA113916 |
NCI NIH HHS |
United States |
| 5UO1CA098233 |
NCI NIH HHS |
United States |
| CA 65725 |
NCI NIH HHS |
United States |
| CA-06-503 |
NCI NIH HHS |
United States |
| CA047988 |
NCI NIH HHS |
United States |
| CA109147 |
NCI NIH HHS |
United States |
| CA116201 |
NCI NIH HHS |
United States |
| CA120120 |
NCI NIH HHS |
United States |
| CA122340 |
NCI NIH HHS |
United States |
| CA132839 |
NCI NIH HHS |
United States |
| CA49449 |
NCI NIH HHS |
United States |
| CA50385 |
NCI NIH HHS |
United States |
| CA67262 |
NCI NIH HHS |
United States |
| CA87969 |
NCI NIH HHS |
United States |
| G0700491 |
Medical Research Council |
United Kingdom |
| HL04385 |
NHLBI NIH HHS |
United States |
| HL080467 |
NHLBI NIH HHS |
United States |
| K01 CA160607 |
NCI NIH HHS |
United States |
| K24 CA169004 |
NCI NIH HHS |
United States |
| N01-HD-3-3175 |
NICHD NIH HHS |
United States |
| P30 CA016056-32 |
NCI NIH HHS |
United States |
| P30 CA016086 |
NCI NIH HHS |
United States |
| P30 ES010126 |
NIEHS NIH HHS |
United States |
| P30-ES10126 |
NIEHS NIH HHS |
United States |
| P50 CA058223 |
NCI NIH HHS |
United States |
| P50 CA089393 |
NCI NIH HHS |
United States |
| P50 CA116201 |
NCI NIH HHS |
United States |
| P50-CA58223 |
NCI NIH HHS |
United States |
| R01 CA077398 |
NCI NIH HHS |
United States |
| R01 CA120120 |
NCI NIH HHS |
United States |
| R01 CA122340 |
NCI NIH HHS |
United States |
| R01-CA100374 |
NCI NIH HHS |
United States |
| R01-CA100598 |
NCI NIH HHS |
United States |
| R01-CA63464 |
NCI NIH HHS |
United States |
| R01-CA73629 |
NCI NIH HHS |
United States |
| R01-CA77305 |
NCI NIH HHS |
United States |
| R25 CA092049 |
NCI NIH HHS |
United States |
| R37-CA54281 |
NCI NIH HHS |
United States |
| RFA-CA-06-503 |
NCI NIH HHS |
United States |
| U01 CA69638 |
NCI NIH HHS |
United States |
| U01-CA69417 |
NCI NIH HHS |
United States |
| U01-CA98216 |
NCI NIH HHS |
United States |
| U01-CA98233 |
NCI NIH HHS |
United States |
| U01-CA98710 |
NCI NIH HHS |
United States |
| U01-CA98758 |
NCI NIH HHS |
United States |
| U01CA69631 |
NCI NIH HHS |
United States |
| U19 CA148065 |
NCI NIH HHS |
United States |
|
Cancer Research UK |
United Kingdom |
|
Intramural NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Breast Neoplasms |
genetics |
| Female |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Receptors, Estrogen |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Receptors, Estrogen |
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC3510753 |
NLM |
|
|
