Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22958575
TITLE
Offspring ADHD as a risk factor for parental marital problems: controls for genetic and environmental confounds.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Previous studies have found that child attention-deficit/hyperactivity disorder (ADHD) is associated with more parental marital problems. However, the reasons for this association are unclear. The association might be due to genetic or environmental confounds that contribute to both marital problems and ADHD.
METHOD NlmCategory: METHODS
Data were drawn from the Australian Twin Registry, including 1,296 individual twins, their spouses, and offspring. We studied adult twins who were discordant for offspring ADHD.Using a discordant twin pairs design, we examined the extent to which genetic and environmental confounds,as well as measured parental and offspring characteristics, explain the ADHD-marital problems association.
RESULTS NlmCategory: RESULTS
Offspring ADHD predicted parental divorce and marital conflict. The associations were also robust when comparing differentially exposed identical twins to control for unmeasured genetic and environmental factors, when controlling for measured maternal and paternal psychopathology,when restricting the sample based on timing of parental divorce and ADHD onset, and when controlling for other forms of offspring psychopathology. Each of these controls rules out alternative explanations for the association.
CONCLUSION NlmCategory: CONCLUSIONS
The results of the current study converge with those of prior research in suggesting that factors directly associated with offspring ADHD increase parental marital problems.
DATE PUBLISHED
2012 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2012/09/10
entrez 2012/09/11 06:00
pubmed 2012/09/11 06:00
medline 2013/02/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Schermerhorn AC Schermerhorn Alice C AC Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
D'Onofrio BM D'Onofrio Brian M BM
Slutske WS Slutske Wendy S WS
Emery RE Emery Robert E RE
Turkheimer E Turkheimer Eric E
Harden KP Harden K Paige KP
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 15
ISSUE: 6
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2012
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA000264 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
HD053550 NICHD NIH HHS United States
HD056354 NICHD NIH HHS United States
HD064795 NICHD NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
R01 HD061817 NICHD NIH HHS United States
T32HD007475 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Attention Deficit Disorder with Hyperactivity psychology
Australia psychology
Divorce psychology
Female psychology
Follow-Up Studies psychology
Gene-Environment Interaction psychology
Humans psychology
Male psychology
Middle Aged psychology
Retrospective Studies psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS463776 NLM
PMC3678725 NLM