Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22955548
TITLE
Substantial genetic overlap between schizotypy and neuroticism: a twin study.
ABSTRACT
Schizotypy is phenotypically associated with neuroticism. To reveal the origin of this association, we assessed 3,349 (1,449 monozygotic, 1,105 dizygotic [DZ] same-sex and 795 DZ opposite-sex) twins on a 12-item version of Chapman's Psychosis-Proneness Scales and the short form of the Eysenck Personality Questionnaire-Revised as measures of schizotypy and neuroticism. A substantial proportion (0.51 with 95 % CI from 0.38 to 0.64) of the phenotypic correlation of 0.37 between neuroticism and the perceptual and ideational components of schizotypy was accounted for by shared genetic influences on these two traits. Moreover, a Cholesky decomposition including anhedonia, hypomania and impulsivity fully accounted for the heritable variance in perceptual and ideational components of schizotypy. These findings suggest a shared genetic etiology between neuroticism and perceptual and ideational components of schizotypy and affect future investigations on the etiology of these phenotypically overlapping traits and affective and psychotic disorders.
DATE PUBLISHED
2012 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/03/20
accepted 2012/07/31
aheadofprint 2012/09/07
entrez 2012/09/08 06:00
pubmed 2012/09/08 06:00
medline 2013/02/06 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Macare C Macare Christine C Department of Psychology, University of Bonn, Kaiser-Karl-Ring 9, 53111, Bonn, Germany. christine.macare@uni-bonn.de
Bates TC Bates Timothy C TC
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
Ettinger U Ettinger Ulrich U
INVESTIGATORS
JOURNAL
VOLUME: 42
ISSUE: 5
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2012
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
K05 AA017688 NIAAA NIH HHS United States
R01 AA007535 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Anhedonia
Female
Humans
Impulsive Behavior psychology
Male psychology
Models, Genetic psychology
Multivariate Analysis psychology
Neuropsychological Tests psychology
Neurotic Disorders psychology
Schizotypal Personality Disorder psychology
Twins, Dizygotic psychology
Twins, Monozygotic psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS515028 NLM
PMC3816282 NLM