|
|
| PMID |
|
|
| TITLE |
|
| DISCOVERY OF GENES THAT AFFECT HUMAN BRAIN CONNECTIVITY: A GENOME-WIDE ANALYSIS OF THE CONNECTOME. |
|
| ABSTRACT |
|
|
|
| Human brain connectivity is disrupted in a wide range of disorders - from Alzheimer's disease to autism - but little is known about which specific genes affect it. Here we conducted a genome-wide association for connectivity matrices that capture information on the density of fiber connections between 70 brain regions. We scanned a large twin cohort (N=366) with 4-Tesla high angular resolution diffusion imaging (105-gradient HARDI). Using whole brain HARDI tractography, we extracted a relatively sparse 70Ã?70 matrix representing fiber density between all pairs of cortical regions automatically labeled in co-registered anatomical scans. Additive genetic factors accounted for 1-58% of the variance in connectivity between 90 (of 122) tested nodes. We discovered genome-wide significant associations between variants and connectivity. GWAS permutations at various levels of heritability, and split-sample replication, validated our genetic findings. The resulting genes may offer new leads for mechanisms influencing aberrant connectivity and neurodegeneration. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2012/08/21 06:00 |
| pubmed |
2012/08/21 06:00 |
| medline |
2012/08/21 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
| Hibar DP |
|
Hibar |
Derrek P |
DP |
|
|
| Ryles A |
|
Ryles |
April |
A |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
|
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
|
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging |
| ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging |
| YEAR: 2012 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: |
| ISSNTYPE: |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Proc IEEE Int Symp Biomed Imaging |
| COUNTRY: United States |
| ISSNLINKING: 1945-7928 |
| NLMUNIQUEID: 101492570 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P41 RR013642 |
NCRR NIH HHS |
United States |
| R01 AG040060 |
NIA NIH HHS |
United States |
| R01 EB008281 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| T15 LM007356 |
NLM NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
