Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
22903354
TITLE
CHANGES IN ANATOMICAL BRAIN CONNECTIVITY BETWEEN AGES 12 AND 30: A HARDI STUDY OF 467 ADOLESCENTS AND ADULTS.
ABSTRACT
Graph theory can be applied to matrices that represent the brain's anatomical connections, to better understand global properties of anatomical networks, such as their clustering, efficiency and "small-world" topology. Network analysis is popular in adult studies of connectivity, but only one study - in just 30 subjects - has examined how network measures change as the brain develops over this period. Here we assessed the developmental trajectory of graph theory metrics of structural brain connectivity in a cross-sectional study of 467 subjects, aged 12 to 30. We computed network measures from 70?70 connectivity matrices of fiber density generated using whole-brain tractography in 4-Tesla 105-gradient high angular resolution diffusion images (HARDI). We assessed global efficiency and modularity, and both age and age(2) effects were identified. HARDI-based connectivity maps are sensitive to the remodeling and refinement of structural brain connections as the human brain develops.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/08/21 06:00
pubmed 2012/08/21 06:00
medline 2012/08/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dennis EL Dennis Emily L EL Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA.
Jahanshad N Jahanshad Neda N
Toga AW Toga Arthur W AW
Johnson K Johnson Kori K
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Martin NG Martin Nicholas G NG
Hickie IB Hickie Ian B IB
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
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MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P41 RR013642 NCRR NIH HHS United States
R01 EB007813 NIBIB NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
T32 MH073526 NIMH NIH HHS United States
GENERAL NOTE
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