Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
22903274
TITLE
DIFFUSION IMAGING PROTOCOL EFFECTS ON GENETIC ASSOCIATIONS.
ABSTRACT
Large multi-site image-analysis studies have successfully discovered genetic variants that affect brain structure in tens of thousands of subjects scanned worldwide. Candidate genes have also associated with brain integrity, measured using fractional anisotropy in diffusion tensor images (DTI). To evaluate the heritability and robustness of DTI measures as a target for genetic analysis, we compared 417 twins and siblings scanned on the same day on the same high field scanner (4-Tesla) with two protocols: (1) 94-directions; 2mm-thick slices, (2) 27-directions; 5mm-thickness. Using mean FA in white matter ROIs and FA 'skeletons' derived using FSL, we (1) examined differences in voxelwise means, variances, and correlations among the measures; and (2) assessed heritability with structural equation models, using the classical twin design. FA measures from the genu of the corpus callosum were highly heritable, regardless of protocol. Genome-wide analysis of the genu mean FA revealed differences across protocols in the top associations.
DATE PUBLISHED
2012
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/08/21 06:00
pubmed 2012/08/21 06:00
medline 2012/08/21 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jahanshad N Jahanshad Neda N Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Kohannim O Kohannim Omid O
Toga AW Toga Arthur W AW
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Hansell NK Hansell Narelle K NK
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2012
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE:
MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
F30 AG041681 NIA NIH HHS United States
P41 RR013642 NCRR NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
T32 GM008042 NIGMS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's