|
|
| PMID |
|
|
| TITLE |
|
| EnigmaVis: online interactive visualization of genome-wide association studies of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. |
|
| ABSTRACT |
|
|
|
| In an attempt to increase power to detect genetic associations with brain phenotypes derived from human neuroimaging data, we recently conducted a large-scale, genome-wide association meta-analysis of hippocampal, brain, and intracranial volume through the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. Here, we present a freely available online interactive tool, EnigmaVis, which makes it easy to visualize the association results generated by the consortium alongside allele frequency, genes, and functional annotations. EnigmaVis runs natively within the web browser, and generates plots that show the level of association between brain phenotypes at user-specified genomic positions. Uniquely, EnigmaVis is dynamic; users can interact with elements on the plot in real time. This software will be useful when exploring the effect on brain structure of particular genetic variants influencing neuropsychiatric illness and cognitive function. Future projects of the consortium and updates to EnigmaVis will also be displayed on the site. EnigmaVis is freely available online at http://enigma.loni.ucla.edu/enigma-vis/ |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2012/08/04 06:00 |
| pubmed |
2012/08/04 06:00 |
| medline |
2012/09/26 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Novak NM |
|
Novak |
Nic M |
NM |
|
Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. |
| Stein JL |
|
Stein |
Jason L |
JL |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| Hibar DP |
|
Hibar |
Derrek P |
DP |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 15 |
| ISSUE: 3 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2012 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, U.S. Gov't, Non-P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Nat Neurosci. 2001 Dec;4(12):1253-8 |
11694885 |
|
| Cites |
Genome Res. 2002 Jun;12(6):996-1006 |
12045153 |
|
| Cites |
Nat Genet. 2007 Jan;39(1):17-23 |
17192785 |
|
| Cites |
Hum Brain Mapp. 2007 Jun;28(6):464-73 |
17415783 |
|
| Cites |
Nat Rev Genet. 2008 May;9(5):356-69 |
18398418 |
|
| Cites |
Nat Genet. 2012 May;44(5):552-61 |
22504417 |
|
| Cites |
Am J Psychiatry. 2009 May;166(5):540-56 |
19339359 |
|
| Cites |
Neuroimage. 2010 Jan 15;49(2):1213-23 |
19786105 |
|
| Cites |
J Am Acad Child Adolesc Psychiatry. 2010 Sep;49(9):884-97 |
20732625 |
|
| Cites |
Nature. 2010 Sep 2;467(7311):52-8 |
20811451 |
|
| Cites |
Bioinformatics. 2010 Sep 15;26(18):2336-7 |
20634204 |
|
| Cites |
Nat Genet. 2008 Jul;40(7):827-34 |
18583979 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P41 EB015922 |
NIBIB NIH HHS |
United States |
| R01 AG040060 |
NIA NIH HHS |
United States |
| U01 AG024904 |
NIA NIH HHS |
United States |
| HD050735 |
NICHD NIH HHS |
United States |
| RC2 AG036535 |
NIA NIH HHS |
United States |
| EB008432 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01 EB008432 |
NIBIB NIH HHS |
United States |
| P41 RR013642 |
NCRR NIH HHS |
United States |
| EB008281 |
NIBIB NIH HHS |
United States |
| R01 MH097268 |
NIMH NIH HHS |
United States |
| R01 EB008281 |
NIBIB NIH HHS |
United States |
| AG036535 |
NIA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Brain |
physiology |
| Databases, Genetic |
physiology |
| Genome-Wide Association Study |
physiology |
| Humans |
physiology |
| Internet |
physiology |
| Meta-Analysis as Topic |
physiology |
| Neuroimaging |
physiology |
| Phenotype |
physiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
